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 Showing 61-74 of 74 Articles
Research Letter 
Lisa-Ann Fraser, MD, MSc; Kuan Liu, MMath; Kyla L. Naylor, MES; Y. Joseph Hwang, MSc; Stephanie N. Dixon, PhD; Salimah Z. Shariff, PhD; Amit X. Garg, MD, PhD
Antipsychotic medications are commonly used in elderly persons to treat dementia and other behavioral disturbances.1 Several articles have linked these medications to an increased risk of fracture.2,3 It is unclear whether this fracture risk is limited to older conventional antipsychotic medications or if the risk extends to newer atypical antipsychotics4 ...
Research Letter 
Shun Yu, MD; Gopi K. Nayak, MD; Jeffrey M. Levsky, MD, PhD; Linda B. Haramati, MD, MS
A substantial proportion of computed tomographic pulmonary angiography (CTPA) results are degraded by patient-related and technical factors, yielding a limited negative interpretation, which qualifies the definitive exclusion of pulmonary embolism. This leads to diagnostic uncertainty and may affect patient management. A multicenter randomized clinical trial of CTPA vs ventilation-perfusion scintigraphy ...
Research Letter 
Mariah L. Kincaid, BS; Lee A. Fleisher, MD; Mark D. Neuman, MD, MSc
Adequate presentation of risks and benefits of medical therapies is essential to informed decision making by patients.1 Transcatheter aortic valve replacement (TAVR) has been recently approved by the US Food and Drug Administration for the treatment of severe aortic stenosis among carefully selected patients; recent randomized clinical trials have identified ...
Invited Commentary: Imbalanced Information on US Hospital Websites; Yael Schenker, MD, MAS; Alex John London, PhD
Viewpoint 
Katherine Baicker, PhD; Helen Levy, PhD
The second open-enrollment period for coverage through the Health Insurance Marketplace extends from November 15, 2014, to February 15, 2015; millions of people in the United States are once again choosing from a menu of plans. Although federal law dictates some aspects of the plans, shopping for coverage—even on health ...
Perspective 
Jonathan Liu, MD
“The ear has pain, very pain. And pus, lots of pus,” the patient’s daughter said with a grimace, as if she were tasting the cloudy, bacteria-laden fluid while she described it. She recounted, as best as she could, the recent plight of her mother, who was seated on the examination ...
Perspective 
Sandra Zimmerman, RN
My husband had been experiencing tremor in his hands for approximately 2 years. He is 69 years old, had worked for many years for a telecommunications company, and is now retired. The tremors come and go unexpectedly. One night they flared up when he was carving a ham. Sometimes he ...
Original Investigation 
Teresa M. Waters, PhD; Michael J. Daniels, ScD; Gloria J. Bazzoli, PhD; Eli Perencevich, MD; Nancy Dunton, PhD; Vincent S. Staggs, PhD; Catima Potter, MPH; Naleef Fareed, PhD; Minzhao Liu, MS, PhD; Ronald I. Shorr, MD, MS

Importance  In 2008, Medicare implemented the Hospital-Acquired Conditions (HACs) Initiative, a policy denying incremental payment for 8 complications of hospital care, also known as never events. The regulation’s effect on these events has not been well studied.

Objective  To measure the association between Medicare’s nonpayment ...

Invited Commentary: Bridge the Knowing-Doing Gap; Craig A. Umscheid, MD, MSCE; Patrick J. Brennan, MD
Original Investigation 
Hongyu Wu, PhD; Alan J. Flint, MD, ScD; Qibin Qi, PhD; Rob M. van Dam, PhD; Laura A. Sampson, RD; Eric B. Rimm, ScD; Michelle D. Holmes, MD, DrPH; Walter C. Willett, MD, DrPH; Frank B. Hu, MD, PhD; Qi Sun, MD, ScD
Includes: Supplemental Content

Importance  Higher intake of whole grains has been associated with a lower risk of major chronic diseases, such as type 2 diabetes mellitus and cardiovascular disease (CVD), although limited prospective evidence exists regarding whole grains’ association with mortality.

Objective  To examine the association between dietary whole ...

Metformin hydrochloride is the first-line drug for type 2 diabetes mellitus (T2DM)1 and is the only oral diabetes drug with evidence for improved cardiovascular outcomes. Despite this, half of the patients with T2DM do not take metformin. Even in patients who are taking other oral T2DM drugs, only about 70% ...
Research Letter 
Amitkumar R. Patel, MD, MBA; Frank J. Zadravecz, MPH; Robert S. Young, MD, MS; Mark V. Williams, MD; Matthew M. Churpek, MD, MPH, PhD; Dana P. Edelson, MD, MS
Hospitals routinely use rapid response teams (RRTs) to treat and triage unstable patients, but early and reliable identification of high-risk patients remains challenging.1 Objective, vital sign–based risk prediction scores, such as the Modified Early Warning Score (MEWS), have been developed but have limited accuracy.2 The Patient Acuity Rating (PAR), a ...
Research Letter 
Robert W. Yeh, MD, MSc; Laura Mauri, MD, MSc; Robert E. Wolf, MS; Iyah K. Romm, BS; Ann Lovett, RN, MA; David Shahian, MD; Sharon-Lise Normand, PhD
Improvements in prevention have led to declines in rates of myocardial infarction (MI).1 Simultaneously, evidence from randomized trials has confirmed the role of medical therapy as a first-line treatment for stable coronary disease.2 Together, these forces could lead to significant declines in population-wide rates of coronary revascularization. We examined recent ...
Research Letter 
Jae Moon Yun, MPH; Dong Wook Shin, MD, DrPH, MBA; Seung-sik Hwang, MD, PhD; Juhee Cho, MA, PhD; You Seon Nam, MD; Jung Hoe Kim, DrPH; Be Long Cho, MD, MPH, PhD
Although antibiotics are not required for treating uncomplicated upper respiratory tract infection (URTI),1 which is mostly viral, they are often prescribed, fueling antibiotic resistance and loss of protective flora. Accordingly, many studies worldwide have tried to decrease inappropriate antibiotic prescribing behavior.2
Perspective 
Austin Lammers, MD; Read Pierce, MD

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