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 Showing 41-60 of 78 Articles
Teachable Moment 
Joanne Smucker, MD; Louis Portas Jr, PharmD, BCPS; Joslyn S. Kirby, MD
Original Investigation 
Marc R. Larochelle, MD, MPH; Fang Zhang, PhD; Dennis Ross-Degnan, ScD; J. Frank Wharam, MBBCh, BAO, MPH
Includes: Supplemental Content

Importance  In the second half of 2010, abuse-deterrent extended-release oxycodone hydrochloride (OxyContin; Purdue Pharma) was introduced and propoxyphene was withdrawn from the US market. The effect of these pharmaceutical market changes on opioid dispensing and overdose rates is unknown.

Objective  To evaluate the association between 2 ...

Invited Commentary: Abuse-Deterrent Opioid Formulations for Reversing the Opioid Epidemic; Hillary V. Kunins, MD, MPH, MS
Original Investigation 
Yariv Gerber, PhD; Susan A. Weston, MS; Margaret M. Redfield, MD; Alanna M. Chamberlain, PhD; Sheila M. Manemann, MPH; Ruoxiang Jiang, BS; Jill M. Killian, BS; Véronique L. Roger, MD, MPH

Importance  Heart failure (HF) is commonly referred to as an epidemic, posing major clinical and public health challenges. Yet, contemporary data on its magnitude and implications are scarce.

Objective  To evaluate recent trends in HF incidence and outcomes overall and by preserved ejection fraction (HFpEF) or ...

Invited Commentary: Heart Failure; Mary Norine Walsh, MD
Original Investigation 
Bjørn O. Åsvold, MD, PhD; Lars J. Vatten, MD, PhD; Trine Bjøro, MD, PhD; Douglas C. Bauer, MD; Alexandra Bremner, PhD; Anne R. Cappola, MD, ScM; Graziano Ceresini, MD, PhD; Wendy P. J. den Elzen, PhD; Luigi Ferrucci, MD, PhD; Oscar H. Franco, MD, PhD; Jayne A. Franklyn, MD, PhD, FRCP, FMedSci; Jacobijn Gussekloo, MD, PhD; Giorgio Iervasi, MD; Misa Imaizumi, MD, PhD; Patricia M. Kearney, MD, PhD; Kay-Tee Khaw, MD; Rui M. B. Maciel, MD; Anne. B. Newman, MD, MPH; Robin P. Peeters, MD, PhD; Bruce M. Psaty, MD, PhD; Salman Razvi, MD, FRCP; José A. Sgarbi, MD; David J. Stott, MD; Stella Trompet, PhD; Mark P. J. Vanderpump, MD, FRCP; Henry Völzke, MD; John P. Walsh, MBBS, FRACP, PhD; Rudi G. J. Westendorp, MD, PhD; Nicolas Rodondi, MD, MAS; for the Thyroid Studies Collaboration
Includes: Supplemental Content

Importance  Some experts suggest that serum thyrotropin levels in the upper part of the current reference range should be considered abnormal, an approach that would reclassify many individuals as having mild hypothyroidism. Health hazards associated with such thyrotropin levels are poorly documented, but conflicting evidence suggests that ...

Invited Commentary 
Hillary V. Kunins, MD, MPH, MS

Rapid increases in the supply of opioid analgesics have largely driven the nearly unremitting increase in overdose deaths in the United States, which have grown by more than 150% over the past decade, from 16 849 in 1999 to 41 502 in 2012.1,2 Since the 1990s, opioid ...

Invited Commentary 
Mary Norine Walsh, MD

Interest is keen in the changing demographics of heart failure (HF) in the United States. As of 2012, an estimated 5.7 million Americans 20 years or older had HF, for a prevalence of 2.2%.1 Heart failure is an important contributor to the burden and cost of national ...

Research Letter 
Margaret C. Fang, MD, MPH; Dongjie Fan, MSPH; Sue Hee Sung, MPH; Daniel M. Witt, PharmD; Steven H. Yale, MD; Steven R. Steinhubl, MD, MS; Alan S. Go, MD

Patients with acute pulmonary embolism (PE) have conventionally been hospitalized for their initial management and initiation of anticoagulant treatment.1 A clinical trial2 found that patients with PE who were considered at low risk by the PE Severity Index could be safely treated as outpatients.3 However, ...

Research Letter 
Jenna VanLiere Canzoniero, MD, MS; Elham Afshar, MD; Helene Hedian, MD; Christina Koch, MD; Daniel J. Morgan, MD, MS

This retrospective cohort study demonstrates patient harm associated with hospitalization for low-risk syncope.

Roy C. Ziegelstein, MD, MACP

This Viewpoint discusses the importance of teaching medical students and residents the skills involved in patient-centered care and communication and enhancing the behavioral and social science content of a medical school’s curriculum and that these skills are just as important as teaching the molecular and genetic basis of ...

Teachable Moment 
Bharat Kumar, MD; Melissa L. Swee, MD, MS
Original Investigation 
Susan L. Greenspan, MD; Subashan Perera, PhD; Mary Anne Ferchak, BSN; David A. Nace, MD; Neil M. Resnick, MD
Includes: Supplemental Content

Importance  Eighty-five percent of institutionalized elderly people have osteoporosis and bone fracture rates 8 to 9 times higher than rates observed among community-dwelling elderly people. Nevertheless, most of these persons are left untreated and are excluded from pivotal osteoporosis trials.

Objective  To determine the efficacy and ...

Invited Commentary: Osteoporosis Treatment and Fracture Outcomes; Robert Lindsay, MB, ChB, PhD
Original Investigation 
Timothy S. Walsh, MD; Lisa G. Salisbury, PhD; Judith L. Merriweather, PhD; Julia A. Boyd, PhD; David M. Griffith, MD; Guro Huby, PhD; Susanne Kean, PhD; Simon J. Mackenzie, MBChB; Ashma Krishan, MSc; Stephanie C. Lewis, PhD; Gordon D. Murray, PhD; John F. Forbes, PhD; Joel Smith, PhD; Janice E. Rattray, PhD; Alastair M. Hull, MD; Pamela Ramsay, PhD; for the RECOVER Investigators
Includes: Supplemental Content

Importance  Critical illness results in disability and reduced health-related quality of life (HRQOL), but the optimum timing and components of rehabilitation are uncertain.

Objective  To evaluate the effect of increasing physical and nutritional rehabilitation plus information delivered during the post–intensive care unit (ICU) acute hospital stay ...

Invited Commentary: Improving Functional Recovery After Critical Illness; Christopher E. Cox, MD, MPH; Catherine L. Hough, MD, MSc
Case Report/Case Series 
Luke Gilman, MD; Dori N. Cage, MD; Adam Horn, MD; Frank Bishop, MD; Warren P. Klam, MD; Andrew P. Doan, MD, PhD

Importance  Excessive use of smartphones has been associated with injuries.

Observations  A 29-year-old, right hand–dominant man presented with chronic left thumb pain and loss of active motion from playing a Match-3 puzzle video game on his smartphone all day for 6 to 8 weeks. On physical ...

Invited Commentary 
Robert Lindsay, MB, ChB, PhD

In this issue of JAMA Internal Medicine, Greenspan and colleagues1 present intriguing data on zoledronic acid, one of the most potent drugs in the bisphosphonate family—if not the most potent—approved for treatment of osteoporosis. In a study of frail elderly women living in nursing homes, the ...

Invited Commentary 
Christopher E. Cox, MD, MPH; Catherine L. Hough, MD, MSc

Conducting clinical research among critically ill patients is a tough business. Few disciplines have experienced such difficulty aligning positive physiologic studies with survival and the other outcomes that matter most to families: functional independence and quality of life. This trend continues with the publication in this issue of ...

Editor's Note 
Rita F. Redberg, MD, MSc

This Editorial Note discusses the effects of post–acute care on variation in Medicare.

Research Letter 
Peter S. Hussey, PhD; Peter Huckfeldt, PhD; Samuel Hirshman, BA; Ateev Mehrotra, MD, MPH

Health care spending varies widely between geographic regions, but there is disagreement regarding the appropriate policy response.1 Regional policies include reducing Medicare payment rates in high-spending regions,2 limiting the supply of health care facilities using certificate-of-need criteria, and implementing care-improvement collaboratives. The Institute of Medicine opposed ...

Editor's Note: Post–Acute Care and Variation in Medicare; Rita F. Redberg, MD, MSc
Research Letter 
Jonathan C. Hsu, MD, MAS; Paul S. Chan, MD, MSc; Fengming Tang, MS; Thomas M. Maddox, MD, MSc; Gregory M. Marcus, MD, MAS

In patients with atrial fibrillation (AF) who are at risk for thromboembolism, anticoagulation therapy with warfarin or the newer novel anticoagulants reduces morbidity and mortality.1,2 Because oral anticoagulant use carries a risk of bleeding, the drugs are not recommended in patients with AF who are ...

Teachable Moment 
Amanda E. Goldberg, MD; Abi Vijenthira, MD; Brian M. Wong, MD
Teachable Moment 
Daniel Schneider, MD, PhD; Douglas Arenberg, MD
Editorial: Selecting the Best Candidates for Lung Cancer Screening; Tanner Caverly, MD, MPH

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