Background Obese individuals who have failed to achieve adequate weight loss with lifestyle changes have limited nonsurgical therapeutic options. We evaluated the efficacy and tolerability of zonisamide, an antiepileptic drug, for enhancing weight loss in obese patients receiving diet and lifestyle guidance.
Methods This was a 1-year, randomized, ...
Arch Intern Med.
Arch Intern Med. Published online October 15, 2012. doi:10.1001/archinternmed.2013.99