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Basic View | Expanded View
 Showing 1-20 of 74 Articles
Original Investigation 
Jacek Skarbinski, MD; Eli Rosenberg, PhD; Gabriela Paz-Bailey, MD, MSc, PhD; H. Irene Hall, PhD; Charles E. Rose, PhD; Abigail H. Viall, MA; Jennifer L. Fagan, MA; Amy Lansky, PhD; Jonathan H. Mermin, MD, MPH
Includes: Supplemental Content

Importance  Human immunodeficiency virus (HIV) transmission risk is primarily dependent on behavior (sexual and injection drug use) and HIV viral load. National goals emphasize maximizing coverage along the HIV care continuum, but the effect on HIV prevention is unknown.

Objectives  To estimate the rate and number ...

Invited Commentary: The HIV Treatment Cascade; Thomas P. Giordano, MD, MPH
Original Investigation 
Tanjaniina Laukkanen, MSc; Hassan Khan, MD, PhD; Francesco Zaccardi, MD; Jari A. Laukkanen, MD, PhD
Includes: Supplemental Content

Importance  Sauna bathing is a health habit associated with better hemodynamic function; however, the association of sauna bathing with cardiovascular and all-cause mortality is not known.

Objective  To investigate the association of frequency and duration of sauna bathing with the risk of sudden cardiac death (SCD), ...

Original Investigation 
Kevin Brown, PhD; Kim Valenta, PhD; David Fisman, MD, MSc; Andrew Simor, MD; Nick Daneman, MD, MSc

Importance  Only a portion of hospital-acquired Clostridium difficile infections can be traced back to source patients identified as having symptomatic disease. Antibiotic exposure is the main risk factor for C difficile infection for individual patients and is also associated with increased asymptomatic shedding. Contact with patients taking ...

Invited Commentary: Antibiotics and Multidrug-Resistant Organisms; L. Clifford McDonald, MD
Original Investigation 
Robert A. Schnoll, PhD; Patricia M. Goelz, MPH; Anna Veluz-Wilkins, MA; Sonja Blazekovic, BA; Lindsay Powers, MA; Frank T. Leone, MD; Peter Gariti, PhD; E. Paul Wileyto, PhD; Brian Hitsman, PhD
Includes: Supplemental Content

Importance  The US Food and Drug Administration adopted labeling for nicotine patches to allow use beyond the standard 8 weeks. This decision was based in part on data showing increased efficacy for 24 weeks of treatment. Few studies have examined whether the use of nicotine patches beyond ...

Invited Commentary 
Thomas P. Giordano, MD, MPH
The human immunodeficiency virus (HIV) treatment cascade provides a snapshot of the effectiveness of the health care system in diagnosing and treating the estimated 1.2 million persons living with HIV infection in the United States.1 Like many concepts in health care, the cascade developed and evolved over time.
Invited Commentary 
Fiona Clement, PhD; Blake Charlton, MD
In the short time since its April 2012 launch by the American Board of Internal Medicine Foundation, the Choosing Wisely campaign has affected more than 60 US specialty societies. Now the campaign is becoming an international phenomenon, as evidenced by Selby et al1 and Gupta and Detsky2 in this issue. ...
Invited Commentary 
L. Clifford McDonald, MD
Conventional wisdom has suggested 2 distinct categories of epidemiologic risk factors in the development of Clostridium difficile infection (CDI): factors that increase the risk of transmission of C difficile and factors that disrupt the patient’s lower intestinal microbiota, a major host defense against infection. This host defense function may be ...
Editor's Note 
Rita F. Redberg, MD, MSc
Often I have advised a patient who was considering an unnecessary test, such as a coronary artery calcium test or carotid ultrasonography from a mobile van, to forgo that test and instead spend the money on something that he or she would actually enjoy, such as a massage or spa ...
Research Letter 
Shlok Gupta, MD; Allan S. Detsky, MD, PhD, FRCPC
As part of the American Board of Internal Medicine Foundation’s Choosing Wisely campaign,1 more than 60 specialty societies have published lists of 5 tests, procedures, or treatments that physicians and patients should question. Recognizing the opportunity for the provision of higher-value care in our own setting, we developed a Choosing ...
Invited Commentary: Challenges in Choosing Wisely’s Future; Fiona Clement, PhD; Blake Charlton, MD
Research Letter 
Kevin Selby, MD; Jean-Michel Gaspoz, MD, MPH; Nicolas Rodondi, MD, MAS; Stefan Neuner-Jehle, MD, MPH; Arnaud Perrier, MD; Andreas Zeller, MD; Jacques Cornuz, MD, MPH
In 2010, the idea emerged of creating lists of low-value health care activities as a way to confront rising medical costs and encourage cost-conscious care. The Good Stewardship Working Group1 and Brody2 pioneered the idea of “top 5” lists, leading to the Choosing Wisely campaign.3 Building on this momentum, there ...
Invited Commentary: Challenges in Choosing Wisely’s Future; Fiona Clement, PhD; Blake Charlton, MD
Original Investigation 
Athanase Benetos, MD, PhD; Carlos Labat, BSc; Patrick Rossignol, MD, PhD; Renaud Fay, PharmD; Yves Rolland, MD, PhD; Filippo Valbusa, MD; Paolo Salvi, MD, PhD; Mauro Zamboni, MD, PhD; Patrick Manckoundia, MD, PhD; Olivier Hanon, MD, PhD; Sylvie Gautier, MD
Includes: Supplemental Content

Importance  Clinical evidence supports the beneficial effects of lowering blood pressure (BP) levels in community-living, robust, hypertensive individuals older than 80 years. However, observational studies in frail elderly patients have shown no or even an inverse relationship between BP and morbidity and mortality.

Objective  To assess ...

Original Investigation 
Nancy E. Avis, PhD; Sybil L. Crawford, PhD; Gail Greendale, MD; Joyce T. Bromberger, PhD; Susan A. Everson-Rose, PhD, MPH; Ellen B. Gold, PhD; Rachel Hess, MD; Hadine Joffe, MD, MSc; Howard M. Kravitz, DO, MPH; Ping G. Tepper, PhD; Rebecca C. Thurston, PhD; for the Study of Women’s Health Across the Nation (SWAN)

Importance  The expected duration of menopausal vasomotor symptoms (VMS) is important to women making decisions about possible treatments.

Objectives  To determine total duration of frequent VMS (≥6 days in the previous 2 weeks) (hereafter total VMS duration) during the menopausal transition, to quantify how long frequent ...

Invited Commentary: Vasomotor Symptom Duration; Gloria Richard-Davis, MD; JoAnn E. Manson, MD, DrPH
Original Investigation 
Matthew Miller, MD, ScD; Catherine W. Barber, MPA; Sarah Leatherman, PhD; Jennifer Fonda, BS; John A. Hermos, MD; Kelly Cho, PhD; David R. Gagnon, MD
Includes: Supplemental Content

Importance  The unprecedented increase in unintentional overdose events that has occurred in tandem with escalating sales of prescription opioids over the past 2 decades has raised concerns about whether the therapeutic use of opioids has contributed to increases in overdose injury. Few controlled studies have examined the ...

Original Investigation 
David S. Black, PhD, MPH; Gillian A. O’Reilly, BS; Richard Olmstead, PhD; Elizabeth C. Breen, PhD; Michael R. Irwin, MD
Includes: Supplemental Content

Importance  Sleep disturbances are most prevalent among older adults and often go untreated. Treatment options for sleep disturbances remain limited, and there is a need for community-accessible programs that can improve sleep.

Objective  To determine the efficacy of a mind-body medicine intervention, called mindfulness meditation, to ...

Invited Commentary: Mindfulness of Later-Life Sleep Quality; Adam P. Spira, PhD
Original Investigation 
Amanda R. Markovitz, MPH; Jeffrey A. Alexander, PhD; Paula M. Lantz, PhD; Michael L. Paustian, PhD
Includes: Supplemental Content

Importance  The patient-centered medical home (PCMH) model of primary care is being implemented in a wide variety of socioeconomic contexts, yet there has been little research on whether its effects differ by context. Clinical preventive service use, including cancer screening, is an important outcome to assess the ...

Invited Commentary 
Adam P. Spira, PhD
Older adults commonly report disturbed sleep, and an expanding literature suggests that poor sleep increases the risk of adverse health outcomes.1 In this issue of JAMA Internal Medicine, Black et al2 present a randomized clinical trial (RCT) among adults 55 years and older with moderately disturbed sleep, comparing a sleep ...
Invited Commentary 
Gloria Richard-Davis, MD; JoAnn E. Manson, MD, DrPH
Vasomotor symptoms (VMS) affect up to 80% of menopausal women and are the most common reason these women seek treatment. Approximately 60% of midlife women seek medical care or advice at least once because of VMS,1 which adversely affect quality of life in domains that include work, social and leisure ...
Editor's Note 
Mitchell H. Katz, MD
All patients would benefit from having a patient-centered medical home. However, Markovitz and colleagues1 show that low-income patients may benefit more than others. Using data from adult primary care physician practices in Michigan, they show that the increases in cancer screening associated with patient-centered medical homes are greater for low-income ...
Editor's Note 
Mitchell H. Katz, MD
JAMA Internal Medicine has run a series of articles on the dangers of prescription opioids for the treatment of chronic pain.1,2 The best solution is to avoid prescribing opioids for chronic pain because there is no high-quality evidence that they are effective for this indication, and the risk of adverse ...

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