Editor's Correspondence |

Immunoglobulins, C3, and the Risk of Myocardial Infarction

Antonio Muscari, MD; Paolo Puddu, MD
Arch Intern Med. 1999;159(19):2364-2365. doi:.
Text Size: A A A
Published online


Kovanen et al1 report an interesting prospective relationship between total IgA, IgG, and IgE levels and myocardial infarction in middle-aged dyslipidemic men with no evidence at baseline of coronary heart disease or any other major disease. The authors appropriately comment on these results, stating that subjects at risk are likely to have a complex immunologic activation, since it is not plausible that the rise in any single specific antibody may be reflected in a significant increase in total immunoglobulins. We have studied this subject with particular reference to serum IgA levels and have concluded that there is no independent prospective association between immunoglobulins and ischemic events.2,3 Indeed, IgA and IgG but not IgM levels tended to be associated with subsequent ischemic events in univariate analysis; however, IgA and IgG levels, again unlike IgM levels, also increased very significantly from the low to middle and high tertiles of C3 distribution.3 According to our data, serum C3 (the third complement component) is the most powerful independent predictor of myocardial infarction, at least in men.3 When our logistic regression model included C3 complement, no significant association between serum immunoglobulins and future ischemic events could be detected.

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles

Users' Guides to the Medical Literature
Clinical Resolution

Users' Guides to the Medical Literature
Clinical Scenario