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Comment & Response |

What Constitutes an Adequate Evaluation of Device-Guided Breathing?

Alison J. Huang, MD, MAS1; Leslee L. Subak, MD2
[+] Author Affiliations
1Department of Medicine, University of California, San Francisco
2Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco
JAMA Intern Med. 2014;174(4):637. doi:10.1001/jamainternmed.2013.13791.
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To the Editor We were surprised that Landman et al1 felt able to draw strong conclusions about the nonefficacy of device-guided breathing for treatment of hypertension based on a methodologically limited study. Conclusions about nonefficacy should only be drawn from negative results when a trial is adequately powered to determine treatment effects. The authors’ study was small (with only 48 participants) and was underpowered based on wide confidence intervals around estimates of blood pressure.

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April 1, 2014
Gijs W. D. Landman, MD, PhD; Kornelis J. J. van Hateren, MD; Nanne Kleefstra, MD, PhD
1Diabetes Centre, Isala Clinics, Zwolle, the Netherlands
1Diabetes Centre, Isala Clinics, Zwolle, the Netherlands2Department of Internal Medicine, University Medical Center Groningen, Groningen, the Netherlands3Langerhans Medical Research Group, Zwolle, the Netherlands
JAMA Intern Med. 2014;174(4):638. doi:10.1001/jamainternmed.2013.13790.
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