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Comment & Response |

Antihypertensive Medications and Breast Cancer Risk

Justine Hugon-Rodin, MD1; Anne Gompel, MD, PhD1; Geneviève Plu-Bureau, MD, PhD1
[+] Author Affiliations
1Department of Gynecology and Endocrinology, Hôpital Universitaire Paris Centre, Paris-Descartes University, Paris, France
JAMA Intern Med. 2014;174(4):640-641. doi:10.1001/jamainternmed.2013.13752.
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To the Editor In their article, Li and colleagues1 assess the association between antihypertensive medication use and increased breast cancer risk in women aged 55 to 74 years. They conclude that only continued use of calcium channel blockers for 10 years or more was significantly associated with a higher risk of breast cancer. However, we query the lack of significant results in their study concerning β-blocker use and breast cancer risk. The potential effect of β-blocker use on the risk of cancer is an important issue, and we believe that the results deserve to be reported stratified by β-adrenergic receptor (AR) antagonist subtype.

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April 1, 2014
Christopher I. Li, MD, PhD; Mei-Tzu C. Tang, PhD; Kathleen E. Malone, PhD
1Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington
JAMA Intern Med. 2014;174(4):641. doi:10.1001/jamainternmed.2013.13740.
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