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Comment & Response |

Antihypertensive Medications and Breast Cancer Risk

Yi Ji, MD, PhD1; Siyuan Chen, MD, PhD2
[+] Author Affiliations
1Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, China
2Intensive Care Unit, West China Hospital of Sichuan University, Chengdu, China
JAMA Intern Med. 2014;174(4):640. doi:10.1001/jamainternmed.2013.13749.
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To the Editor We read with great interest the article published in JAMA Internal Medicine titled “Use of Antihypertensive Medications and Breast Cancer Risk Among Women Aged 55 to 74 Years” by Li et al.1 The study provided further evidence that long-term current use of calcium channel blockers is associated with an increased risk of breast cancer. Moreover, the data revealed that a reduction in breast cancer risk was associated with long-term use of angiotensin-converting enzyme inhibitors. We appreciate the authors’ extraordinary contribution, which provides us with a basis for further investigation of the effects of antihypertensive medications on breast cancer risk. Nonetheless, there are several major points that need further discussion with respect to this article.

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April 1, 2014
Christopher I. Li, MD, PhD; Mei-Tzu C. Tang, PhD; Kathleen E. Malone, PhD
1Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington
JAMA Intern Med. 2014;174(4):641. doi:10.1001/jamainternmed.2013.13740.
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