http://archinte.jamanetwork.com/ en-us Wed, 22 Aug 2012 00:00:00 GMT Tue, 01 Jan 2013 00:52:12 GMT Silverchair editor@archinte.jamanetwork.com webmaster@archinte.jamanetwork.com http://archinte.jamanetwork.com/article.aspx?articleID=485387 Mon, 10 Jul 2000 00:00:00 GMT Yamagata H, Kiyohara Y, Aoyagi K, et al. <span class="paragraphSection"><div class="boxTitle">Background</div>Several nested case-control studies have reported the potentially causal relationship between <span style="font-style:italic;">Helicobacter pylori</span> infection and the development of gastric cancer. However, there has been no prospective study evaluating this issue. The purpose of this study is to examine the impact of <span style="font-style:italic;">H pylori</span> infection on gastric cancer occurrence in a general Japanese population (Hisayama, Japan) stratified according to sex, using a prospective study design.<div class="boxTitle">Methods</div>A total of 2602 subjects aged 40 years or older (1070 men; mean age, 57 years; 1532 women; mean age, 59 years) without a history of gastrectomy or gastric cancer were classified according to the status of the serum IgG antibodies to <span style="font-style:italic;">H pylori</span> and observed prospectively for 9 years from 1988.<div class="boxTitle">Results</div>Infection of <span style="font-style:italic;">H pylori</span> was more common in men (71.5%) than in women (62.5%; P<.001). The age-adjusted incidence of gastric cancer for men (5.3 per 1000 person-years) was 4-fold higher than that for women (1.3; P<.001). In men, the age-adjusted incidence of gastric cancer was significantly higher in the subjects with <span style="font-style:italic;">H pylori</span> infection than in those without it (6.2 vs 2.5; relative risk, 2.59 [95% confidence interval, 1.03-6.50]), whereas no significant difference was observed in women (1.2 vs 1.1; relative risk, 0.99 [95% confidence interval, 0.36-2.68]). These results were similar even after controlling for other risk factors in multivariate analysis. It was estimated that 40.1% of gastric cancers for men in this cohort were attributable to <span style="font-style:italic;">H pylori</span> infection.<div class="boxTitle">Conclusion</div>A significant relationship exists between infection with H pylori and subsequent occurrence of gastric cancer for men but not for women in this Japanese population.</span> 160 13 1962 1968 10.1001/archinte.160.13.1962 http://archinte.jamanetwork.com/article.aspx?articleID=485387