JAMA Internal Medicine: Musculoskeletal Syndromes Topic Collection http://archinte.jamanetwork.com/ en-us Mon, 11 Feb 2013 00:00:00 GMT Fri, 15 Feb 2013 15:59:39 GMT Silverchair editor@archinte.jamanetwork.com webmaster@archinte.jamanetwork.com New Statins Also Produce Fatigue: Spontaneous Reporting as a Complementary System to Increase Safety Knowledge http://archinte.jamanetwork.com/article.aspx?articleID=1570242 Mon, 11 Feb 2013 00:00:00 GMT Tarapués M, Cereza G, Figueras A. <span class="paragraphSection">We have read with interest the Research Letter by Golomb et al about the effects of statins on energy and fatigue with exertion. The Research Letter describes the first randomized evidence of these adverse drug reactions (ADRs) for simvastatin and pravastatin, previously reported as anecdotal cases in the literature. The study attracted our attention because it has tied up loose ends after signal detection by pharmacovigilance systems based on spontaneous reporting. Notwithstanding, at the same time it has been a stimulus to look for new data after posing the question “Do the new statins also produce these adverse effects?”</span> 173 3 247 248 10.1001/jamainternmed.2013.1614 http://archinte.jamanetwork.com/article.aspx?articleID=1570242 New Statins Also Produce Fatigue: Spontaneous Reporting as a Complementary System to Increase Safety Knowledge—Reply http://archinte.jamanetwork.com/article.aspx?articleID=1570243 Mon, 11 Feb 2013 00:00:00 GMT Golomb BA, Koperski S. <span class="paragraphSection">In reply</span> 173 3 247 248 10.1001/jamainternmed.2013.2113 http://archinte.jamanetwork.com/article.aspx?articleID=1570243