http://archinte.jamanetwork.com/ en-us Sat, 01 Dec 2012 00:00:00 GMT Tue, 01 Jan 2013 00:46:27 GMT Silverchair editor@archinte.jamanetwork.com webmaster@archinte.jamanetwork.com http://archinte.jamanetwork.com/article.aspx?articleID=1386052 Mon, 22 Oct 2012 00:00:00 GMT Marfella R, Carella C, Paolisso G. <span class="paragraphSection">We thank Razvi et al for their informative article on subclinical thyroid disease. The study by Razvi et al provides useful information regarding the importance of recognizing subclinical hypothyroidism (SCH) in anticipation of decreasing cardiac risks, although definitive long-term prospective controlled studies proving the benefits of treatment in various age groups have not been performed. In this context, we observed that innate immune overactivity is associated with an unstable phenotype of atherosclerotic plaques in patients with SCH enlisted to undergo endoarterectomy for high-grade (>70%) carotid artery stenosis. In particular, macrophages were significantly more abundant in SCH atherosclerotic lesions compared with control lesions, and it was associated with higher nuclear-factor–κB, tumor necrosis factor, and matrix-metalloproteinase-9 levels, along with less interstitial collagen content. All of this might increase the risk of acute ischemic events precipitated by inflammatory-dependent rupture of atherosclerotic plaques.</span> 172 19 1523 1524 10.1001/archinternmed.2012.4409 http://archinte.jamanetwork.com/article.aspx?articleID=1386052 http://archinte.jamanetwork.com/article.aspx?articleID=1386053 Mon, 22 Oct 2012 00:00:00 GMT Razvi S, Pearce SS. <span class="paragraphSection">In reply</span> 172 19 1523 1524 10.1001/2013.jamainternmed.597 http://archinte.jamanetwork.com/article.aspx?articleID=1386053