http://archinte.jamanetwork.com/ en-us Wed, 12 Dec 2012 00:00:00 GMT Tue, 01 Jan 2013 00:46:01 GMT Silverchair editor@archinte.jamanetwork.com webmaster@archinte.jamanetwork.com http://archinte.jamanetwork.com/article.aspx?articleID=1105935 Mon, 26 Sep 2011 00:00:00 GMT de Boer IH, Paterson AD, Brunzell JD. <span class="paragraphSection">In reply</span> 171 17 1596 1597 10.1001/archinternmed.2011.414 http://archinte.jamanetwork.com/article.aspx?articleID=1105935 http://archinte.jamanetwork.com/article.aspx?articleID=1106302 Mon, 26 Sep 2011 00:00:00 GMT Gosmanov AR, Gosmanova EO. <span class="paragraphSection">In the March 14, 2011, issue of the Archives, de Boer et al characterize long-term renal outcomes in patients with type 1 diabetes mellitus (T1DM) and microalbuminuria from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. The data indicate that, within 10 years after commencement of microalbuminuria in patients with T1DM, 40% of patients will regress to normoalbuminuria and 47% of patients will progress to severe nephropathy. After rigorous statistical analysis, the authors identified several clinical factors that were associated with favorable microalbuminuria outcomes such as lower blood pressure, lower glycated hemoglobin level, absence of retinopathy, and favorable lipid profile. We would like to note that the authors have not discussed several facts learned from genetic analyses of T1DM studies including the DCCT study that could be worth mentioning.</span> 171 17 1596 1597 10.1001/archinternmed.2011.413 http://archinte.jamanetwork.com/article.aspx?articleID=1106302