http://archinte.jamanetwork.com/ en-us Sat, 01 Dec 2012 00:00:00 GMT Tue, 01 Jan 2013 00:44:42 GMT Silverchair editor@archinte.jamanetwork.com webmaster@archinte.jamanetwork.com http://archinte.jamanetwork.com/article.aspx?articleID=625126 Mon, 28 Mar 2005 00:00:00 GMT Reinharth D. <span class="paragraphSection">I found the recent article “Treatment Options in Knee Osteoarthritis” quite informative, particularly because it addressed a practical patient management issue. However, one key finding was discordant with my own experience managing this disease: in my practice, few patients have been willing to try treatment with capsaicin cream, and none has continued using it on a long-term basis. There are many barriers to the use of capsaicin: many patients prefer pills, 4 times daily dosing is difficult to comply with (this frequency is recommended for the first 2 weeks of use, as opposed to the 3 times daily “utility” the authors selected), and the cream burns (apparently ignored by the authors). It is my unscientific impression that my patients generally prefer treatment with acetaminophen (and cyclooxygenase-2 inhibitors before the recent troubles for this class of drugs) for their osteoarthritis.</span> 165 6 702 702 10.1001/archinte.165.6.702 http://archinte.jamanetwork.com/article.aspx?articleID=625126