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 Showing 61-80 of 81 Articles
Research Letter 
Ravi Gupta, BS, BA; Aaron S. Kesselheim, MD, JD, MPH; Nicholas Downing, MD; Jeremy Greene, MD, PhD; Joseph S. Ross, MD, MHS

This study uses US Food and Drug Administration data to identify approved generic drugs manufactured between September 30, 1984, and January 11, 2016 and compares the effects of number of generic drugs associated with brand-name drugs.

Research Letter 
Alan B. Zonderman, PhD; Nicolle A. Mode, MS; Ngozi Ejiogu, MD; Michele K. Evans, MD

This study uses data from the Healthy Aging in Neighborhoods of Diversity across the Life Span study to examine the contributions of sex, race, and socioeconomic differences to overall mortality in middle-aged adults.

Viewpoint 
Lydia A. Flier, MD; Christopher R. Henderson, MD, MPhil; Carolyn L. Treasure, MD

This Invited Commentary examines arguments in favor of discontinuing the Step 2 Clinical Skills Examination.

Perspective 
Neil Skolnik, MD

I am leaving a room where I had a discussion with a son and daughter who strongly desired that their 94-year-old mother with severe dementia, chronic obstructive pulmonary disease, a history of heart disease with triple-bypass surgery, and 2 repaired hip fractures continue her statin and all her ...

Original Investigation 
Anupam B. Jena, MD, PhD; Andrew R. Olenski, BS; Daniel M. Blumenthal, MD, MBA
Includes: Supplemental Content

Importance  Limited evidence exists on salary differences between male and female academic physicians, largely owing to difficulty obtaining data on salary and factors influencing salary. Existing studies have been limited by reliance on survey-based approaches to measuring sex differences in earnings, lack of contemporary data, small sample ...

Invited Commentary: Equal Pay for Equal Work for Physicians; Vineet M. Arora, MD, MAPP
Original Investigation 
Eric C. Sun, MD, PhD; Beth D. Darnall, PhD; Laurence C. Baker, PhD; Sean Mackey, MD, PhD
Includes: Supplemental Content

Importance  Chronic opioid use imposes a substantial burden in terms of morbidity and economic costs. Whether opioid-naive patients undergoing surgery are at increased risk for chronic opioid use is unknown, as are the potential risk factors for chronic opioid use following surgery.

Objective  To characterize the ...

Original Investigation 
Michaël Chassé, MD, PhD, FRCPC; Alan Tinmouth, MD, MSc, FRCPC; Shane W. English, MD, MSc, FRCPC; Jason P. Acker, MBA, PhD; Kumanan Wilson, MD, FRCPC; Greg Knoll, MD, MSc, FRCPC; Nadine Shehata, MD, MSc, FRCPC; Carl van Walraven, MD, MSc, FRCPC; Alan J. Forster, MD, MSc, FRCPC; Timothy Ramsay, PhD; Lauralyn A. McIntyre, MD, MSc, FRCPC; Dean A. Fergusson, MHA, PhD
Includes: Supplemental Content

Importance  While red blood cells (RBCs) are administered to improve oxygen delivery and patient outcomes, they also have been associated with potential harm. Unlike solid organ transplantation, the clinical consequences of donor characteristics on recipients have not been evaluated in transfusion medicine.

Objective  To analyze the ...

Invited Commentary: Blood Donor Demographics and Transfusion Recipient Survival; Harvey G. Klein, MD
Invited Commentary 
Vineet M. Arora, MD, MAPP
Invited Commentary 
Harvey G. Klein, MD

Blood for transfusion is a drug or, more specifically, a biological medicine.1 The US Food and Drug Administration regulates blood for purity, potency, and safety under the Food, Drug, and Cosmetic Act of 1938. Regulatory authorities in most developed countries prescribe blood collection, storage, testing, labeling, and ...

Review 
Joshua R. Lakin, MD; Susan D. Block, MD; J. Andrew Billings, MD; Luca A. Koritsanszky, MPH; Rebecca Cunningham, MD; Lisa Wichmann, RN, MS, ACM, NC-BC; Doreen Harvey, BSN, RN, CCM, NC-BC; Jan Lamey, MS; Rachelle E. Bernacki, MD, MS
Includes: Supplemental Content

Importance  The Institute of Medicine recently called for systematic improvements in clinician-led conversations about goals, values, and care preferences for patients with serious and life-threatening illnesses. Studies suggest that these conversations are associated with improved outcomes for patients and their families, enhanced clinician satisfaction, and lower health ...

Teachable Moment 
Ploa Desforges, MD; Todd C. Lee, MD, MPH; Emily G. McDonald, MD, MSc

This Teachable Moment discusses nonpharmacologic interventions prior to prescribing quetiapine, benzodiazepines, or sedative hypnotic drugs for the short-term treatment of insomnia in older adult patients.

Research Letter 
Todd C. Lee, MD, MPH; Ploa Desforges, MD; Jennifer Murray, MScPH; Ramy R. Saleh, MD; Emily G. McDonald, MD, MSc

This study describes safety and efficacy in the use of quetiapine in a prospective cohort of inpatients and the proportion of in-hospital use that is perpetuated on discharge.

Original Investigation 
Jing Luo, MD, MPH; John D. Seeger, PharmD, DrPH; Macarius Donneyong, PhD; Joshua J. Gagne, PharmD, ScD; Jerry Avorn, MD; Aaron S. Kesselheim, MD, JD, MPH
Includes: Supplemental Content

Importance  In November 2011, the cholesterol level–lowering medication atorvastatin calcium became available in the United States as a generic drug. However, only a single generic form (from a manufacturer that qualified for market exclusivity by challenging several of Pfizer’s patents) and an authorized generic form (a brand-name ...

Invited Commentary: Brand-Name Medications vs Available Generic Alternatives; Walid F. Gellad, MD, MPH; Chester B. Good, MD, MPH
Original Investigation 
Gilbert Gonzales, PhD, MHA; Julia Przedworski, BS; Carrie Henning-Smith, PhD, MPH, MSW

Importance  Previous studies identified disparities in health and health risk factors among lesbian, gay, and bisexual (LGB) adults, but prior investigations have been confined to samples not representative of the US adult population or have been limited in size or geographic scope. For the first time in ...

Editor's Note: Health Care for LGB People Comes Out of the Closet; Mitchell H. Katz, MD
Original Investigation 
Emily R. Adrion, PhD, MSc; Andrew M. Ryan, PhD; Amanda C. Seltzer, MHSA; Lena M. Chen, MD, MS; John Z. Ayanian, MD, MPP; Brahmajee K. Nallamothu, MD, MPH
Includes: Supplemental Content

Importance  Patients’ out-of-pocket spending for major health care expenses, such as inpatient care, may result in substantial financial distress. Limited contemporary data exist on out-of-pocket spending among nonelderly adults.

Objectives  To evaluate out-of-pocket spending associated with hospitalizations and to assess how this spending varied over time ...

Editor's Note: Health Insurance for Emergency Hospitalization; Mitchell H. Katz, MD
Invited Commentary 
Walid F. Gellad, MD, MPH; Chester B. Good, MD, MPH

In December 1996, 8 days before Christmas, the US Food and Drug Administration (FDA) approved Lipitor (atorvastatin; Pfizer) for the treatment of hyperlipidemia. Lipitor would become one of the most profitable prescription drugs in history, bringing in $130 billion in sales during its lifetime as a brand-name product ...

Some years ago I developed appendicitis—my vague abdominal pain turned into rebound tenderness during the course of an afternoon seeing patients. I walked myself from the outpatient area of the hospital to the emergency department, told the attending physician I had appendicitis, climbed onto a gurney, and had ...

Editor's Note 
Mitchell H. Katz, MD

Delivering patient-centered care requires an understanding of the psychosocial and behavioral determinants of health. The article by Gonzales et al1 in this issue of JAMA Internal Medicine demonstrates that one such determinant, sexual orientation, has an influential effect on several aspects of health. Psychological distress was more ...

An article by Sato et al has been retracted.

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