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 Showing 61-68 of 68 Articles
Original Investigation 
Hung N. Luu, MD, PhD; William J. Blot, PhD; Yong-Bing Xiang, MD, MPH; Hui Cai, MD, PhD; Margaret K. Hargreaves, PhD; Honglan Li, MD, MPH; Gong Yang, MD, MPH; Lisa Signorello, ScD; Yu-Tang Gao, MD; Wei Zheng, MD, PhD; Xiao-Ou Shu, MD, PhD
Includes: Supplemental Content

Importance  High intake of nuts has been linked to a reduced risk of mortality. Previous studies, however, were primarily conducted among people of European descent, particularly those of high socioeconomic status.

Objective  To examine the association of nut consumption with total and cause-specific mortality in Americans ...

Editor's Note: Live Longer…for Peanuts; Mitchell H. Katz, MD
Original Investigation 
Emily G. McDonald, MD; Jonathon Milligan, MD; Charles Frenette, MD; Todd C. Lee, MD, MPH
Includes: Supplemental Content

Importance  Clostridium difficile infection (CDI) is associated with significant morbidity, mortality, and a high risk of recurrence. Proton pump inhibitor (PPI) use is associated with an initial episode of CDI, and PPIs are frequently overprescribed. For many, the use of PPIs could likely be discontinued before CDI ...

Invited Commentary 
Margaret C. Fang, MD, MPH
The recent 2014 American Heart Association, American College of Cardiology, and Heart Rhythm Society guideline for the management of patients with atrial fibrillation (AF) recommends using the CHA2DS2-VASc stroke risk score instead of the older CHADS2 score when deciding whether to recommend anticoagulant therapy, in essence lowering the threshold at ...
Editor's Note 
Mitchell H. Katz, MD
Multiple studies have demonstrated the beneficial effects of eating nuts. Nonetheless, the editors felt it was worth publishing another such study for 2 reasons. First, this study1 combined 3 cohorts to produce a large and diverse sample, including a predominately low socioeconomic cohort of Americans and 2 Chinese cohorts. The ...
Research Letter 
Emily C. O’Brien, PhD; Sunghee Kim, PhD; Paul L. Hess, MD; Peter R. Kowey, MD; Gregg C. Fonarow, MD; Jonathan P. Piccini, MD, MHS; Eric D. Peterson, MD, MPH
In 2014, the American Heart Association, American College of Cardiology, and Heart Rhythm Society published a revised guideline for atrial fibrillation (AF) treatment recommending use of a refined stroke risk score and revised threshold for oral anticoagulation (OAC) initiation.1 We assessed the potential effect of this new guideline by comparing ...
Invited Commentary: New Atrial Fibrillation Guideline; Margaret C. Fang, MD, MPH
Research Letter 
Mallika L. Mendu, MD, MBA; Andrew Lundquist, MD; Ayal A. Aizer, MD, MHS; David E. Leaf, MD, MMSc; Emily Robinson, MD, MPH; David J. R. Steele, MD; Sushrut S. Waikar, MD, MPH
Chronic kidney disease (CKD) affects approximately 13% of adults in the United States and is associated with significant morbidity, mortality, and costs.1- 3 There is a broad differential for CKD, including diabetes mellitus, hypertension, glomerulonephritis, tubulointerstitial disease, urologic causes, and unknown causes.2 To our knowledge, a comprehensive assessment of the ...
Original Investigation 
Athanase Benetos, MD, PhD; Carlos Labat, BSc; Patrick Rossignol, MD, PhD; Renaud Fay, PharmD; Yves Rolland, MD, PhD; Filippo Valbusa, MD; Paolo Salvi, MD, PhD; Mauro Zamboni, MD, PhD; Patrick Manckoundia, MD, PhD; Olivier Hanon, MD, PhD; Sylvie Gautier, MD
Includes: Supplemental Content

Importance  Clinical evidence supports the beneficial effects of lowering blood pressure (BP) levels in community-living, robust, hypertensive individuals older than 80 years. However, observational studies in frail elderly patients have shown no or even an inverse relationship between BP and morbidity and mortality.

Objective  To assess ...

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