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 Showing 61-73 of 73 Articles
A newly proposed US Food and Drug Administration guidance could undermine the agency's drug safety laws and regulations by allowing pharmaceutical companies to claim their drugs are less risky than stated in the approved label.
Editor's Note 
Joseph S. Ross, MD, MHS
Reconciling the results of randomized clinical trials (RCTs) and observational studies remains a substantial challenge for clinical medicine. There are numerous examples of studies showing that therapies seemed effective, or perhaps conferred risk, when investigated by observational methods that were later contradicted by evidence from RCTs, and vice versa. A ...
Invited Commentary 
Alan H. B. Wu, PhD
I was coming home from a long work week at the hospital and thought of stopping by the video store to rent a copy of the latest Hollywood blockbuster video. I called my wife from my office telephone to tell her I’d be late. I wasn’t sure where the store ...
Research Letter 
Gautam R. Shroff, MBBS; Brooke M. Heubner, MS; Charles A. Herzog, MD
We examined temporal trends in the incidence of acute coronary syndrome (ACS) among US Medicare beneficiaries.
Research Letter 
Helmut Schröder, PhD; Jordi Salas-Salvadó, MD, PhD; Miguel Angel Martínez-González, MD, PhD; Montserrat Fíto, MD, PhD; Dolores Corella, DPharm, PhD; Ramón Estruch, MD, PhD; Emilio Ros, MD, PhD
Lifestyle modification, particularly dietary changes, is the cornerstone of population-based strategies for cardiovascular disease (CVD) prevention.1 Recently the Prevención con Dieta Mediterránea (PREDIMED) study,2 a 5-year randomized primary prevention trial (isrctn.org Identifier: ISRCTN35739639), showed a 30% reduction in incident CVD with Mediterranean diet (MeDiet) intervention in comparison with a control ...
Research Letter 
Jesse Theisen-Toupal, MD; Gary Horowitz, MD; Anthony Breu, MD
Since the United States began folic acid fortification in 1998, the prevalence of folate deficiency in the general population has decreased.1 Despite this, folate testing continues to be recommended for the evaluation of macrocytic anemia2,3 and is commonly performed to evaluate macrocytosis without anemia, normocytic anemia, dementia, delirium, and peripheral ...
Original Investigation 
Trisha F. Hue, PhD, MPH; Steven R. Cummings, MD; Jane A. Cauley, DrPH; Douglas C. Bauer, MD; Kristine E. Ensrud, MD; Elizabeth Barrett-Connor, MD; Dennis M. Black, PhD

Importance  Studies have shown that bisphosphonates may have antitumor and antimetastatic properties. Recently, observational studies have suggested a possible protective effect of bisphosphonates on breast cancer, but the effect of bisphosphonate use on risk of breast cancer has not been tested in randomized trials.

Objective  To ...

Original Investigation 
An Hong Tran, MD; Eunis Wai Man Ngor, MS; Bechien U. Wu, MD, MPH
Includes: Supplemental Content

Importance  The risks and benefits of surveillance colonoscopy in elderly patients have not been well characterized.

Objective  To investigate the relative impact of surveillance colonoscopy in elderly patients compared with a reference cohort.

Design, Setting, and Participants  Retrospective cohort study from 2001 through 2010 of ...

Original Investigation 
Philippe Gabriel Steg, MD; Nicola Greenlaw, MSc; Michal Tendera, MD; Jean-Claude Tardif, MD; Roberto Ferrari, MD; Muayed Al-Zaibag, MD; Paul Dorian, MD; Dayi Hu, MD; Svetlana Shalnova, MD; Fernando José Sokn, MD; Ian Ford, PhD; Kim M. Fox, MD; for the Prospective Observational Longitudinal Registry of Patients With Stable Coronary Artery Disease (CLARIFY) Investigators
Includes: Supplemental Content

Importance  In the era of widespread revascularization and effective antianginals, the prevalence and prognostic effect of anginal symptoms and myocardial ischemia among patients with stable coronary artery disease (CAD) are unknown.

Objective  To describe the current clinical patterns among patients with stable CAD and the association ...

Bryan LeBude, MD; Gretchen Diemer, MD
In the 1920s, when George Papanicolaou began to develop the screening test that now bears his name, the cause of cervical cancer was not known, and the cancer was a common cause of death among women. Since Papanicolaou testing entered clinical practice in the 1950s, however, cervical cancer incidence and ...
In June 2014, the US Supreme Court ruled that some employers can decide for themselves whether the contraceptive mandate in the Affordable Care Act (ACA) is a substantial burden on the exercise of religious freedom (Box)2 and sue for an exemption on that basis. What are the broader implications of ...

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