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 Showing 41-60 of 84 Articles
Invited Commentary 
Raj Patel, PhD

Approximately 80% of calories eaten in the United States are grown domestically.1 Yet, the US diet is a leading cause of morbidity. The analysis by Siegel et al2 in this issue of JAMA Internal Medicine suggests that through commodity subsidies that encourage poor diet we are, ...

Invited Commentary 
Stacey Prenner, MD; Mary E. Rinella, MD

Long-term nutritional excess coupled with reduced physical activity has fueled the rise of obesity-related metabolic conditions. In many countries with high population density, overnutrition is now responsible for more morbidity than undernutrition. Nonalcoholic fatty liver disease (NAFLD) is 1 of the consequences of the imbalance between caloric intake ...

Editor's Note 
Anna L. Parks, MD; Kenneth E. Covinsky, MD

One of the most fraught choices clinicians make is deciding which older patients should receive anticoagulant therapy. Risk of thrombosis and bleeding both increase with age, and these risks must be balanced with the burdens of anticoagulant monitoring, cost, adherence, and polypharmacy.1 Studies evaluating the net benefit ...

Special Communication 
William S. Weintraub, MD; William E. Boden, MD

Percutaneous coronary intervention (PCI) continues to be performed frequently for patients with stable ischemic heart disease, despite uncertain efficacy. Individual randomized trial data and meta-analyses have not demonstrated that PCI in addition to optimal medical therapy reduces the incidence of death or myocardial infarction in patients with stable ...

Research Letter 
Andrea L. Schaffer, MSc, MBiostat; Nicholas A. Buckley, MD; Rose Cairns, PhD; Sallie-Anne Pearson, PhD

This study evaluates the effect of rescheduling alprazolam on benzodiazepine prescribing, dispensing, and intentional poisonings.

Peer Reviewers List  FREE
Editorial: JAMA Internal Medicine—The Year in Review, 2015; Rita F. Redberg, MD, MSc
Gabriela Spencer Bonilla, BA; Rene Rodriguez-Gutierrez, MD, MSc; Victor M. Montori, MD, MSc

This Viewpoint examines socioeconomic factors associated with type 2 diabetes.

Brian Klepper, PhD

A couple of months before Elaine died from peritoneal cancer, we hired Anila, a cheerful, hearty Albanian housecleaner. On her first visit, Anila saw that Elaine was bedridden. “Kerosene can save her,” she said. “There is science. Look it up on the Internet.” Later, Elaine and I had ...

Invited Commentary: The Team Approach to Advanced Cancer Care—Redefining the Gold Standard; Sunny Wang, MD; Barbara D. Drye, MD; Patricia A. Cornett, MD
Teachable Moment 
Anubha Agarwal, MD; Adva Eisenberg, MD; Suzanne K. Woods, MD

This case of an otherwise healthy man in his 30s who presented to an optometrist with sudden-onset horizontal diplopia and blurry vision illustrates the importance of assessing the prior probability of an underlying disease before diagnostic testing is undertaken and considering how test results may influence treatment.

Original Investigation 
Thomas A. Dewland, MD; Elsayed Z. Soliman, MD, MSc, MS; Barry R. Davis, MD, PhD; Jared W. Magnani, MD, MSc; Jose-Miguel Yamal, PhD; Linda B. Piller, MD, MPH; L. Julian Haywood, MD; Alvaro Alonso, MD, PhD; Christine M. Albert, MD, MPH; Gregory M. Marcus, MD, MAS; for the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Collaborative Research Group
Includes: Supplemental Content

Importance  Cardiac conduction abnormalities are associated with an increased risk for morbidity and mortality, and understanding factors that accelerate or delay conduction system disease could help to identify preventive and therapeutic strategies. Antifibrotic and anti-inflammatory properties of angiotensin-converting enzyme inhibitors and treatment for hyperlipidemia may reduce the ...

Invited Commentary: Cardiac Conduction System Disease; Sanjiv M. Narayan, MD, PhD; Tina Baykaner, MD, MPH; David J. Maron, MD
Original Investigation 
Liana C. Del Gobbo, PhD; Fumiaki Imamura, PhD; Stella Aslibekyan, PhD; Matti Marklund, PhD; Jyrki K. Virtanen, PhD; Maria Wennberg, PhD; Mohammad Y. Yakoob, PhD; Stephanie E. Chiuve, ScD; Luicito dela Cruz, PhD; Alexis C. Frazier-Wood, PhD; Amanda M. Fretts, MPH, PhD; Eliseo Guallar, PhD; Chisa Matsumoto, PhD, MD; Kiesha Prem, MSc; Tosh Tanaka, PhD; Jason H. Y. Wu, PhD; Xia Zhou, PhD; Catherine Helmer, MD, PhD; Erik Ingelsson, MD, PhD; Jian-Min Yuan, MD, PhD; Pascale Barberger-Gateau, PhD; Hannia Campos, PhD; Paulo H. M. Chaves, MD, PhD; Luc Djoussé, MD, ScD; Graham G. Giles, PhD; Jose Gómez-Aracena, PhD; Allison M. Hodge, PhD; Frank B. Hu, PhD, MD, MPH; Jan-Håkan Jansson, MD, PhD; Ingegerd Johansson, PhD; Kay-Tee Khaw, PhD, MD; Woon-Puay Koh, PhD; Rozenn N. Lemaitre, PhD, MPH; Lars Lind, PhD; Robert N. Luben, PhD; Eric B. Rimm, ScD; Ulf Risérus, PhD, MD; Cecilia Samieri, PhD; Paul W. Franks, PhD; David S. Siscovick, MPH, MD; Meir Stampfer, DrPH, MD; Lyn M. Steffen, PhD, MPH; Brian T. Steffen, PhD; Michael Y. Tsai, PhD; Rob M. van Dam, PhD; Sari Voutilainen, PhD; Walter C. Willett, DrPH, MD; Mark Woodward, PhD; Dariush Mozaffarian, MD, DrPH; for the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCe)
Includes: Supplemental Content

Importance  The role of ω-3 polyunsaturated fatty acids for primary prevention of coronary heart disease (CHD) remains controversial. Most prior longitudinal studies evaluated self-reported consumption rather than biomarkers.

Objective  To evaluate biomarkers of seafood-derived eicosapentaenoic acid (EPA; 20:5ω-3), docosapentaenoic acid (DPA; 22:5ω-3), and docosahexaenoic acid (DHA; ...

Original Investigation 
Araz Rawshani, MD, PhD; Ann-Marie Svensson, PhD; Björn Zethelius, MD, PhD; Björn Eliasson, MD, PhD; Annika Rosengren, MD, PhD; Soffia Gudbjörnsdottir, MD, PhD
Includes: Supplemental Content

Importance  The association between socioeconomic status and survival based on all-cause, cardiovascular (CV), diabetes-related, and cancer mortality in type 2 diabetes has not been examined in a setting of persons with equitable access to health care with adjustment for important confounders.

Objective  To determine whether income, ...

Original Investigation 
Jing Luo, MD, MPH; John D. Seeger, PharmD, DrPH; Macarius Donneyong, PhD; Joshua J. Gagne, PharmD, ScD; Jerry Avorn, MD; Aaron S. Kesselheim, MD, JD, MPH
Includes: Supplemental Content

Importance  In November 2011, the cholesterol level–lowering medication atorvastatin calcium became available in the United States as a generic drug. However, only a single generic form (from a manufacturer that qualified for market exclusivity by challenging several of Pfizer’s patents) and an authorized generic form (a brand-name ...

Invited Commentary: Brand-Name Medications vs Available Generic Alternatives; Walid F. Gellad, MD, MPH; Chester B. Good, MD, MPH
Original Investigation 
Gilbert Gonzales, PhD, MHA; Julia Przedworski, BS; Carrie Henning-Smith, PhD, MPH, MSW

Importance  Previous studies identified disparities in health and health risk factors among lesbian, gay, and bisexual (LGB) adults, but prior investigations have been confined to samples not representative of the US adult population or have been limited in size or geographic scope. For the first time in ...

Editor's Note: Health Care for LGB People Comes Out of the Closet; Mitchell H. Katz, MD
Original Investigation 
Emily R. Adrion, PhD, MSc; Andrew M. Ryan, PhD; Amanda C. Seltzer, MHSA; Lena M. Chen, MD, MS; John Z. Ayanian, MD, MPP; Brahmajee K. Nallamothu, MD, MPH
Includes: Supplemental Content

Importance  Patients’ out-of-pocket spending for major health care expenses, such as inpatient care, may result in substantial financial distress. Limited contemporary data exist on out-of-pocket spending among nonelderly adults.

Objectives  To evaluate out-of-pocket spending associated with hospitalizations and to assess how this spending varied over time ...

Editor's Note: Health Insurance for Emergency Hospitalization; Mitchell H. Katz, MD
Invited Commentary 
Sanjiv M. Narayan, MD, PhD; Tina Baykaner, MD, MPH; David J. Maron, MD

Cardiac conduction system disorders on the electrocardiogram (ECG) are common. Left bundle branch block (LBBB) is associated with adverse outcomes, and variants previously considered normal, such as right bundle branch block (RBBB),1 left anterior fascicular block,2 or PR interval prolongation,3 may also portend morbidity and ...

Invited Commentary 
Sunny Wang, MD; Barbara D. Drye, MD; Patricia A. Cornett, MD

We empathize greatly with Dr Klepper for his loss. His compelling reflection on his wife’s care for peritoneal cancer highlights the struggles many cancer patients and their families face when battling incurable cancer. Dr Klepper advances 2 themes in his thought-provoking essay; the first addresses what is high-quality ...

Invited Commentary 
Walid F. Gellad, MD, MPH; Chester B. Good, MD, MPH

In December 1996, 8 days before Christmas, the US Food and Drug Administration (FDA) approved Lipitor (atorvastatin; Pfizer) for the treatment of hyperlipidemia. Lipitor would become one of the most profitable prescription drugs in history, bringing in $130 billion in sales during its lifetime as a brand-name product ...

Some years ago I developed appendicitis—my vague abdominal pain turned into rebound tenderness during the course of an afternoon seeing patients. I walked myself from the outpatient area of the hospital to the emergency department, told the attending physician I had appendicitis, climbed onto a gurney, and had ...

Editor's Note 
Mitchell H. Katz, MD

Delivering patient-centered care requires an understanding of the psychosocial and behavioral determinants of health. The article by Gonzales et al1 in this issue of JAMA Internal Medicine demonstrates that one such determinant, sexual orientation, has an influential effect on several aspects of health. Psychological distress was more ...

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