We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Basic View | Expanded View
 Showing 41-60 of 62 Articles
Edward N. Murphy, MD; Richard Miranda, MD
Original Investigation 
Brian L. Rostron, PhD, MPH; Cindy M. Chang, PhD, MPH; Terry F. Pechacek, PhD
Includes: Supplemental Content

Importance  Cigarette smoking has been found to harm nearly every bodily organ and is a leading cause of preventable disease, but current estimates of smoking-attributable morbidity by condition for the United States are generally unavailable.

Objective  To estimate the burden of major medical conditions attributable to ...

Original Investigation 
Bo Wang, PharmD; William J. Canestaro, MSc; Niteesh K. Choudhry, MD, PhD
Includes: Supplemental Content

Importance  Genetic biomarkers that predict a drug’s efficacy or likelihood of toxicity are assuming increasingly important roles in the personalization of pharmacotherapy, but concern exists that evidence that links use of some biomarkers to clinical benefit is insufficient. Nevertheless, information about the use of biomarkers appears in ...

Invited Commentary 
Wylie Burke, MD, PhD; Kenneth Thummel, PhD
Individual differences in response to medications are an important challenge in clinical practice. Drugs that work well for some patients are ineffective for others, and individuals vary markedly in their experience of adverse drug reactions. Some of this variation is associated with individual differences in the genes involved in drug ...
Invited Commentary 
Steven A. Schroeder, MD
The most striking statistic on the harms of smoking is the number of estimated deaths from tobacco exposure. There are an estimated 480 000 annual deaths caused by tobacco use in the United States,1 and approximately 5.7 million deaths each year globally, making smoking the most common cause of preventable ...
Editor's Note 
Robert Steinbrook, MD
Lung cancer, the vast majority of cases of which are caused by smoking, is the leading cause of cancer deaths in both men and women in the United States. In 2014, about 160 000 people are expected to die from lung cancer, accounting for about 27% of all cancer deaths.1 ...
Special Communication 
Douglas E. Wood, MD, FRCSEd

The National Lung Screening Trial has provided convincing evidence of a substantial mortality benefit of lung cancer screening with low-dose computed tomography (CT) for current and former smokers at high risk. The United States Preventive Services Task Force has recommended screening, triggering coverage of low-dose CT by private ...

Special Communication 
Steven H. Woolf, MD, MPH; Russell P. Harris, MD, MPH; Doug Campos-Outcalt, MD, MPA

In 2013, the US Preventive Services Task Force (USPSTF) recommended low-dose computed tomographic (CT) screening for high-risk current and former smokers with a B recommendation (indicating a level of certainty that it offered moderate to substantial net benefit). Under the Affordable Care Act, the USPSTF recommendation requires commercial ...

Viewpoint  FREE
Michael T. Osterholm, PhD, MPH; Kristine A. Moore, MD, MPH; Lawrence O. Gostin, JD
This Viewpoint discusses several key public health lessons learned from the current West Africa Ebola epidemic that are changing the way we think about emerging infectious disease threats.
Katherine T. Hamilton, MD; Benjamin J. Lee, MD
Original Investigation 
Nicolas Garin, MD; Daniel Genné, MD; Sebastian Carballo, MD, DPhil; Christian Chuard, MD; Gerhardt Eich, MD; Olivier Hugli, MD, MPH; Olivier Lamy, MD; Mathieu Nendaz, MD, MHPE; Pierre-Auguste Petignat, MD; Thomas Perneger, MD, PhD; Olivier Rutschmann, MD, MPH; Laurent Seravalli, MD; Stephan Harbarth, MD, MS; Arnaud Perrier, MD
Includes: Supplemental Content

Importance  The clinical benefit of adding a macrolide to a β-lactam for empirical treatment of moderately severe community-acquired pneumonia remains controversial.

Objective  To test noninferiority of a β-lactam alone compared with a β-lactam and macrolide combination in moderately severe community-acquired pneumonia.

Design, Setting, and Participants  ...

Original Investigation 
Peter K. Lindenauer, MD, MSc; Tara Lagu, MD, MPH; Joseph S. Ross, MD, MHS; Penelope S. Pekow, PhD; Amy Shatz, MPH; Nicholas Hannon, BS; Michael B. Rothberg, MD, MPH; Evan M. Benjamin, MD
Includes: Supplemental Content

Importance  Public reporting of quality is considered a key strategy for stimulating improvement efforts at US hospitals; however, little is known about the attitudes of hospital leaders toward existing quality measures.

Objectives  To describe US hospital leaders’ attitudes toward hospital quality measures found on the Centers ...

Original Investigation 
Jin Wang, MD; Pan Wang, BPharm; Xinghe Wang, PhD; Yingdong Zheng, PhD; Yonghong Xiao, MD, PhD
Includes: Supplemental Content

Importance  Appropriate antibiotic use is a key strategy to control antibacterial resistance. The first step in achieving this is to identify the major problems in antibiotic prescription in health care facilities, especially in primary health care settings, which is where most patients receive medical care.

Objective  ...

Original Investigation 
Nancy R. Cook, ScD; Paul M Ridker, MD
Includes: Supplemental Content

Importance  While the pooled cohort equations from the recent American College of Cardiology/American Heart Association (ACC/AHA) Guideline on the Assessment of Cardiovascular Risk have overestimated cardiovascular risk in multiple external cohorts, the reasons for the discrepancy are unclear.

Objective  To determine whether increased use of statins ...

Invited Commentary 
Steven E. Nissen, MD
Thomas Jefferson, the third American President and author of the Declaration of Independence, famously opined, “Governments derive their just powers from the consent of the governed.” The principle underlying this simple statement is an essential component of any collection of rules that govern how individuals conform to behavioral standards. Clinical ...
Invited Commentary 
Michael Bell, MD
Antibiotics are an essential medical resource. The ability to treat infections not only saves lives but provides a safety net for medical advances that now seem routine: trauma surgery, cancer chemotherapy, and stem cell and organ transplantation—each inherently reliant on effective antibiotics in order to deliver their life-saving potential. Antibiotic ...
Invited Commentary 
Lara Goitein, MD
Is there too much focus on measuring and reporting quality rather than on the conditions needed for improving it? The Centers for Medicare & Medicaid Services (CMS) and other organizations require physicians and hospitals to publicly report performance on quality measures, and the CMS and private payers are tying reimbursement ...
Invited Commentary 
Jonathan S. Lee, MD; Michael J. Fine, MD, MSc
Although our understanding of pneumonia dates back thousands of years to when symptoms were recognized by Hippocrates, the first typical bacterial pathogen responsible for causing community-acquired pneumonia (CAP), Streptococcus pneumoniae, was not isolated until the late 19th century. Another half a century passed before 3 atypical bacteria were discovered as ...
Challenges in Clinical Electrocardiography 
Curtis M. Steyers III, MD; Prashant D. Bhave, MD
A 64-year-old white woman presented to the emergency department for evaluation of episodic palpitations and chest tightness. On arrival to the emergency department, her symptoms had entirely resolved. A 12-lead electrocardiogram (ECG) was obtained while she was asymptomatic and is shown in Figure 1A. Minutes later, the patient developed recurrence ...
Research Letter 
Jeffrey A. Linder, MD, MPH; Jason N. Doctor, PhD; Mark W. Friedberg, MD, MPP; Harry Reyes Nieva, BA; Caroline Birks, MD; Daniella Meeker, PhD; Craig R. Fox, PhD
Clinicians make many patient care decisions each day. The cumulative cognitive demand of these decisions may erode clinicians’ abilities to resist making potentially inappropriate choices. Psychologists, who refer to the erosion of self-control after making repeated decisions as decision fatigue,1,2 have found evidence that it affects nonmedical professionals. For example, ...

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Subscribe to the journal