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 Showing 41-60 of 89 Articles
Research Letter 
Emily G. McDonald, MD; Todd C. Lee, MD, MPH

Central venous catheters (CVCs) facilitate secure access in critically ill patients and allow for the administration of caustic substances. Potential harms include bloodstream infections1 and thromboembolism.2 A recent study showed that 21.2% of physicians were unaware that their patient had a CVC3 and therefore were ...

Editor's Note: Reducing Inappropriate Use of Central Venous Catheters; Deborah Grady, MD, MPH
Udayan K. Shah, MD; Carol DiMura, MSN; Deepak Agrawal, MD

This Viewpoint discusses the potential to improve patient care by identifying routines and paperwork that do not contribute to patient care or safety.

Saurabh Jha, MD, MS

“She had a normal CT yesterday. Why another?” I asked the physician.

Teachable Moment 
Wade Nicholson Harrison, MPH; John F. Dick III, MD; Thom Walsh, PhD
Original Investigation 
Susan P. Y. Wong, MD; William Kreuter, MPA; J. Randall Curtis, MD, MPH; Yoshio N. Hall, MD, MS; Ann M. O’Hare, MD, MA
Includes: Supplemental Content

Importance  Understanding cardiopulmonary resuscitation (CPR) practices and outcomes can help to support advance care planning in patients receiving maintenance dialysis.

Objective  To characterize patterns and outcomes of in-hospital CPR in US adults receiving maintenance dialysis.

Design, Setting, and Participants  This national retrospective cohort study studied ...

Invited Commentary: Dialysis; Emilee R. Wilhelm-Leen, MD; Glenn M. Chertow, MD, MPH
Original Investigation 
Frederika A. van Nimwegen, MSc; Michael Schaapveld, PhD; Cécile P. M. Janus, MD; Augustinus D. G. Krol, MD, PhD; Eefke J. Petersen, MD, PhD; John M. M. Raemaekers, MD, PhD; Wouter E. M. Kok, MD, PhD; Berthe M. P. Aleman, MD, PhD; Flora E. van Leeuwen, PhD
Includes: Supplemental Content

Importance  Hodgkin lymphoma (HL) survivors are at increased risk of cardiovascular diseases. It is unclear, however, how long the increased risk persists and what the risk factors are for various cardiovascular diseases.

Objectives  To examine relative and absolute excess risk up to 40 years since HL ...

Invited Commentary: Hodgkin Lymphoma Survivors; Emily Tonorezos, MD, MPH; Linda Overholser, MD, MPH
Invited Commentary 
Emilee R. Wilhelm-Leen, MD; Glenn M. Chertow, MD, MPH

More than 400 000 persons in the United States are currently receiving maintenance dialysis as life-sustaining treatment for end-stage renal disease (ESRD), with more than 90% receiving in-center hemodialysis. Mortality rates in the ESRD population in the United States remain extremely high (18%-20% per year) despite a slight downward ...

Invited Commentary 
Emily Tonorezos, MD, MPH; Linda Overholser, MD, MPH

There are currently more than 13 million individuals with a history of cancer living in the United States.1 Of these, an estimated 400 000 are adult survivors of childhood cancer2; with ongoing progress in cancer treatment and supportive care, that estimate is expected to increase. Cardiovascular ...

Research Letter 
Waqas T. Qureshi, MD; Wesley T. O’Neal, MD, MPH; Yulia Khodneva, MD, PhD; Suzanne Judd, PhD; Monika M. Safford, MD; Paul Muntner, PhD; Elsayed Z. Soliman, MD, MSc, MS

This cross-sectional study demonstrates that opioid use is associated with an increased prevalence of atrial fibrillation.

Research Letter 
Adam Bonica, PhD; Howard Rosenthal, PhD; David J. Rothman, PhD

We recently reported that between 1991 and 2012, the political alignment of American physicians shifted from predominantly Republican toward the Democrats.1 In 2014, the Republican surge changed party control of Congress: the Republicans gained 9 Senate seats and became the majority party there, and the Republican majority ...

Neal Baer, MD

This Viewpoint discusses why the presence of reality television cameras in the emergency department inevitably conflicts with good patient care.

Teachable Moment 
Joanne Smucker, MD; Louis Portas Jr, PharmD, BCPS; Joslyn S. Kirby, MD
Original Investigation 
Marc R. Larochelle, MD, MPH; Fang Zhang, PhD; Dennis Ross-Degnan, ScD; J. Frank Wharam, MBBCh, BAO, MPH
Includes: Supplemental Content

Importance  In the second half of 2010, abuse-deterrent extended-release oxycodone hydrochloride (OxyContin; Purdue Pharma) was introduced and propoxyphene was withdrawn from the US market. The effect of these pharmaceutical market changes on opioid dispensing and overdose rates is unknown.

Objective  To evaluate the association between 2 ...

Invited Commentary: Abuse-Deterrent Opioid Formulations for Reversing the Opioid Epidemic; Hillary V. Kunins, MD, MPH, MS
Original Investigation 
Yariv Gerber, PhD; Susan A. Weston, MS; Margaret M. Redfield, MD; Alanna M. Chamberlain, PhD; Sheila M. Manemann, MPH; Ruoxiang Jiang, BS; Jill M. Killian, BS; Véronique L. Roger, MD, MPH

Importance  Heart failure (HF) is commonly referred to as an epidemic, posing major clinical and public health challenges. Yet, contemporary data on its magnitude and implications are scarce.

Objective  To evaluate recent trends in HF incidence and outcomes overall and by preserved ejection fraction (HFpEF) or ...

Invited Commentary: Heart Failure; Mary Norine Walsh, MD
Original Investigation 
Bjørn O. Åsvold, MD, PhD; Lars J. Vatten, MD, PhD; Trine Bjøro, MD, PhD; Douglas C. Bauer, MD; Alexandra Bremner, PhD; Anne R. Cappola, MD, ScM; Graziano Ceresini, MD, PhD; Wendy P. J. den Elzen, PhD; Luigi Ferrucci, MD, PhD; Oscar H. Franco, MD, PhD; Jayne A. Franklyn, MD, PhD, FRCP, FMedSci; Jacobijn Gussekloo, MD, PhD; Giorgio Iervasi, MD; Misa Imaizumi, MD, PhD; Patricia M. Kearney, MD, PhD; Kay-Tee Khaw, MD; Rui M. B. Maciel, MD; Anne. B. Newman, MD, MPH; Robin P. Peeters, MD, PhD; Bruce M. Psaty, MD, PhD; Salman Razvi, MD, FRCP; José A. Sgarbi, MD; David J. Stott, MD; Stella Trompet, PhD; Mark P. J. Vanderpump, MD, FRCP; Henry Völzke, MD; John P. Walsh, MBBS, FRACP, PhD; Rudi G. J. Westendorp, MD, PhD; Nicolas Rodondi, MD, MAS; for the Thyroid Studies Collaboration
Includes: Supplemental Content

Importance  Some experts suggest that serum thyrotropin levels in the upper part of the current reference range should be considered abnormal, an approach that would reclassify many individuals as having mild hypothyroidism. Health hazards associated with such thyrotropin levels are poorly documented, but conflicting evidence suggests that ...

Invited Commentary 
Hillary V. Kunins, MD, MPH, MS

Rapid increases in the supply of opioid analgesics have largely driven the nearly unremitting increase in overdose deaths in the United States, which have grown by more than 150% over the past decade, from 16 849 in 1999 to 41 502 in 2012.1,2 Since the 1990s, opioid ...

Invited Commentary 
Mary Norine Walsh, MD

Interest is keen in the changing demographics of heart failure (HF) in the United States. As of 2012, an estimated 5.7 million Americans 20 years or older had HF, for a prevalence of 2.2%.1 Heart failure is an important contributor to the burden and cost of national ...

Research Letter 
Margaret C. Fang, MD, MPH; Dongjie Fan, MSPH; Sue Hee Sung, MPH; Daniel M. Witt, PharmD; Steven H. Yale, MD; Steven R. Steinhubl, MD, MS; Alan S. Go, MD

Patients with acute pulmonary embolism (PE) have conventionally been hospitalized for their initial management and initiation of anticoagulant treatment.1 A clinical trial2 found that patients with PE who were considered at low risk by the PE Severity Index could be safely treated as outpatients.3 However, ...

Research Letter 
Jenna VanLiere Canzoniero, MD, MS; Elham Afshar, MD; Helene Hedian, MD; Christina Koch, MD; Daniel J. Morgan, MD, MS

This retrospective cohort study demonstrates patient harm associated with hospitalization for low-risk syncope.

Roy C. Ziegelstein, MD, MACP

This Viewpoint discusses the importance of teaching medical students and residents the skills involved in patient-centered care and communication and enhancing the behavioral and social science content of a medical school’s curriculum and that these skills are just as important as teaching the molecular and genetic basis of ...

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