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 Showing 41-57 of 57 Articles
Original Investigation 
Cynthia J. Brown, MD, MSPH; Kathleen T. Foley, PhD, OTR/L; John D. Lowman Jr, PhD, PT; Paul A. MacLennan, PhD; Javad Razjouyan, PhD; Bijan Najafi, PhD; Julie Locher, PhD; Richard M. Allman, MD
Includes: Supplemental Content

Importance  Low mobility is common during hospitalization and associated with loss or declines in ability to perform activities of daily living (ADL) and limitations in community mobility.

Objective  To examine the effect of an in-hospital mobility program (MP) on posthospitalization function and community mobility.

Design, Setting, ...

Invited Commentary: Epidemic of Low Mobility in Hospitalized Seniors; S. Ryan Greysen, MD, MHS
Original Investigation 
Christina J. Charlesworth, MPH; Thomas H. A. Meath, MPH; Aaron L. Schwartz, PhD; K. John McConnell, PhD
Includes: Supplemental Content

Importance  Reducing unnecessary tests and treatments is a potentially promising approach for improving the value of health care. However, relatively little is known about whether insurance type or local practice patterns are associated with delivery of low-value care.

Objectives  To compare low-value care in the Medicaid ...

Invited Commentary 
S. Ryan Greysen, MD, MHS

Bedrest is toxic to older adults. Initially a clinical observation,1 this statement has become axiomatic in geriatric medicine and now rests on nearly 3 decades of rigorous scientific investigation demonstrating underlying pathophysiologic mechanisms of immobility and clinical outcomes research demonstrating associations with disability, nursing home placement, and ...

Invited Commentary 
Laura Esserman, MD, MBA

The Perspective by Jan Vick Harris1 should be a wake-up call to physicians, especially those taking care of patients with breast cancer. Harris was given a diagnosis with the word “cancer” in the title. Her first association was her dad—he died young, 8 weeks after his lung ...

Challenges in Clinical Electrocardiography 
Shing Ching, MBBS; Chiu Sun Yue, MBBS, MRCP

A woman in her 60s presented to the emergency department with palpitation and dyspnea. Her blood pressure was 154/78 mm Hg, her pulse was 184 beats per minute, and the arrhythmia did not respond to adenosine. What is your diagnosis?

Research Letter 
Louis-Marie Terrier, MD; Aymeric Amelot, MD, PhD; Stéphane Velut, MD, PhD; Patrick François, MD, PhD; Ilyess Zemmoura, MD, PhD

This case report describes a patient presenting with the lyre-shaped abdominal striae associated with Cushing syndrome.

My father, an aeronautical engineer and one of the designers of the reentry heat shields for the Apollo spacecraft, was extremely methodical. Even when doing projects around the house, he would measure and remeasure before making a final cut.

Invited Commentary: A Maturing Use of Defibrillators; Joanne Lynn, MD
Original Investigation 
Michael Bretthauer, MD; Michal F. Kaminski, MD; Magnus Løberg, MD; Ann G. Zauber, PhD; Jaroslaw Regula, MD; Ernst J. Kuipers, MD; Miguel A. Hernán, MD; Eleanor McFadden, MA; Annike Sunde, MSc; Mette Kalager, MD; Evelien Dekker, MD; Iris Lansdorp-Vogelaar, PhD; Kjetil Garborg, MD; Maciej Rupinski, MD; Manon C. W. Spaander, MD; Marek Bugajski, MD; Ole Høie, MD; Tryggvi Stefansson, MD; Geir Hoff, MD; Hans-Olov Adami, MD; for the Nordic-European Initiative on Colorectal Cancer (NordICC) Study Group
Includes: Supplemental Content

Importance  Although some countries have implemented widespread colonoscopy screening, most European countries have not introduced it because of uncertainty regarding participation rates, procedure-related pain and discomfort, endoscopist performance, and effectiveness. To our knowledge, no randomized trials on colonoscopy screening currently exist.

Objective  To investigate participation rate, ...

Invited Commentary: Colorectal Cancer Screening With Colonoscopy; David Lieberman, MD
Original Investigation 
Christina Abdel Shaheed, PhD; Chris G. Maher, PhD; Kylie A. Williams, PhD; Richard Day, MD; Andrew J. McLachlan, PhD
Includes: Supplemental Content

Importance  Opioid analgesics are commonly used for low back pain, however, to our knowledge there has been no systematic evaluation of the effect of opioid dose and use of enrichment study design on estimates of treatment effect.

Objective  To evaluate efficacy and tolerability of opioids in ...

Original Investigation 
Susan M. McCurry, PhD; Katherine A. Guthrie, PhD; Charles M. Morin, PhD; Nancy F. Woods, PhD, RN; Carol A. Landis, PhD, RN; Kristine E. Ensrud, MD, MPH; Joseph C. Larson, MS; Hadine Joffe, MD, MSc; Lee S. Cohen, MD; Julie R. Hunt, PhD; Katherine M. Newton, PhD; Julie L. Otte, PhD, RN; Susan D. Reed, MD, MPH; Barbara Sternfeld, PhD; Lesley F. Tinker, PhD; Andrea Z. LaCroix, PhD
Includes: Supplemental Content

Importance  Effective, practical, nonpharmacologic therapies are needed to treat menopause-related insomnia symptoms in primary and women’s specialty care settings.

Objective  To evaluate the efficacy of telephone-based cognitive behavioral therapy for insomnia (CBT-I) vs menopause education control (MEC).

Design, Setting, and Participants  A single-site, randomized clinical ...

Invited Commentary 
David Lieberman, MD

Colorectal cancer screening in individuals at average risk is effective, although the screening test considered the best remains uncertain. Randomized studies of fecal occult blood testing (conducted in the 1990s) and one-time screening sigmoidoscopy (conducted in the 2000s) demonstrated that patients who were screened had colorectal cancer detected ...

Invited Commentary 
Joanne Lynn, MD

When implantable cardioverter-defibrillators (ICDs) were first in broad use, about 20 years ago,1 they often seemed like a near-magical way to kick a troublesome heart back into doing its job. Without the serious risks and low yield of external cardiopulmonary resuscitation, a person could be resuscitated without ...

Challenges in Clinical Electrocardiography 
Jennifer M. Wright, MD; Michael E. Field, MD

A man in his 60s with prior heart transplantation presented with intermittent syncope. Cardiac ultrasonography and laboratory examination showed normal left ventricular function and clinical examination did not reveal any evidence of rejection. During an episode of lightheadedness, the following 12-lead electrocardiogram (ECG) was obtained (Figure 1...

Research Letter 
Robert Ferrari, MD, MSc (Med), FRCPC; Connie Prosser, PhD, FCACB

This article describes a criteria-based approach to testing vitamin D levels.

Research Letter 
James N. Kirkpatrick, MD; Paul J. Hauptman, MD; Keith M. Swetz, MD; Elizabeth D. Blume, MD; Kimberlee Gauvreau, ScD; Mathew Maurer, MD; Sarah J. Goodlin, MD

This survey study assesses attitudes among clinicians toward palliative care in patients receiving transcatheter aortic valve replacement and ventricular assist devices.

Evidence to Practice 
Samia Mora, MD, MHS
Comment & Response 
Charlotte Andersson, MD, PhD

To the Editor We have regretfully discovered an error in our program underlying the analyses of the paper “Association of β-Blocker Therapy With Risks of Adverse Cardiovascular Events and Deaths in Patients With Ischemic Heart Disease Undergoing Noncardiac Surgery: A Danish Nationwide Cohort Study” (2014;174[3]:336-344).1

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