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 Showing 41-60 of 79 Articles
Original Investigation 
Vinay Prasad, MD, MPH; Chul Kim, MD, MPH; Mauricio Burotto, MD; Andrae Vandross, MD
Includes: Supplemental Content

Importance  The strength of association between surrogate end points and survival in oncology is important to understand because surrogate end points are frequently used in oncology clinical trials, supporting US Food and Drug Administration approvals and National Comprehensive Cancer Network guideline recommendations.

Objective  To identify and ...

Editor's Note: Faster Drug Approvals Not Always Better, Can Be Worse; Rita F. Redberg, MD, MSc
Invited Commentary 
Deborah L. Myers, MD

About one-quarter of adults in the United States are obese.1 Among its myriad adverse effects on health, obesity affects the support and function of the pelvic floor. As obesity increases, the pelvic floor disorders of urinary incontinence, anal incontinence, and (for women) pelvic organ prolapse become more ...

Editor's Note 
Joseph S. Ross, MD, MHS

The system by which the US Food and Drug Administration engages in medical device postmarket safety surveillance needs strengthening.14 Efforts are limited by reliance on passively aggregated adverse events through the Manufacturer and User Facility Device Experience (MAUDE) database, investigated adverse events at select clinical ...

Editor's Note 
Rita F. Redberg, MD, MSc

A shared goal of all health professionals is to relieve suffering and prolong life. At times these goals are at odds, particularly in oncology care. Patients with severe disease and low chance of survival may be offered therapies in the hope of buying a few more weeks or ...

Research Letter 
Lin Yang, PhD; Graham A. Colditz, MD, DrPH

Overweight and obesity are associated with various chronic conditions.1 These conditions are considerable health care and societal burdens, yet could potentially be averted by preventing weight gain and obesity. In a prior analysis, now almost 20 years old, Must et al2 used a nationally representative data ...

Research Letter 
Kush R. Desai, MD; Robert J. Lewandowski, MD; Riad Salem, MD, MBA; Samdeep K. Mouli, MD; Jennifer K. Karp, RN; James L. Laws, BS; Robert K. Ryu, MD

This single-center review reports that retrieval of inferior vena cava filters after a prolonged dwell time has a high rate of safety and success in patients at risk for pulmonary embolism.

Perspective 
Anton Travis Manasco, MD; Judith A. Linden, MD

Her name was Claire. She resided in a local nursing home and had advanced dementia, coronary artery disease, diabetes mellitus, and hypertension. She was nonverbal from multiple prior cerebrovascular accidents and her worsening dementia. When I opened her medical record, an orange Do Not Resuscitate/Intubate sheet shined through ...

Teachable Moment 
Sarah M. Kuhn, MD; Ruchi Jain, DO; Kristi M. Moore, MD
Teachable Moment 
Michael J. Nabozny, MD; Nicole M. Steffens, MPH; Margaret L. Schwarze, MD, MPP
Editorial 
Gail R. Wilensky, PhD; Rita F. Redberg, MD, MSc

This year has already seen a major piece of significant bipartisan legislation1 as well as continued unfolding of many challenges in achieving meaningful health care reform.

Original Investigation 
Elyse R. Park, PhD, MPH; Ilana F. Gareen, PhD; Sandra Japuntich, PhD; Inga Lennes, MD; Kelly Hyland, BA; Sarah DeMello, MS; JoRean D. Sicks, MS; Nancy A. Rigotti, MD
Includes: Supplemental Content

Importance  The National Lung Screening Trial (NLST) found a reduction in lung cancer mortality among participants screened with low-dose computed tomography vs chest radiography. In February 2015, Medicare announced its decision to cover annual lung screening for patients with a significant smoking history. These guidelines promote smoking ...

Invited Commentary: Tobacco Cessation; Michael K. Ong, MD, PhD
Original Investigation 
Samuel Pannick, MA, MBBS, MRCP; Rachel Davis, PhD; Hutan Ashrafian, PhD, MRCS; Ben E. Byrne, MB, BChir; Iain Beveridge, MB, BChir, FRCP; Thanos Athanasiou, MD, PhD; Robert M. Wachter, MD; Nick Sevdalis, PhD
Includes: Supplemental Content

Importance  Improving the quality of health care for general medical patients is a priority, but the organization of general medical ward care receives less scrutiny than the management of specific diseases. Optimizing teams’ performance improves patient outcomes in other settings, and interdisciplinary practice is a major target ...

Invited Commentary: Inpatient Interdisciplinary Care; Hilary J. Mosher, MFA, MD; Peter J. Kaboli, MD, MS
Original Investigation 
Quyen Q. Tiet, PhD; Yani E. Leyva, PhD; Rudolf H. Moos, PhD; Susan M. Frayne, MD, MPH; Lars Osterberg, MD, MPH; Brandy Smith, BA
Includes: Supplemental Content

Importance  Illicit drug use is prevalent, and primary care provides an ideal setting in which to screen for drug use disorders (DUDs) and negative consequences of drug use (NCDU). Comprehensive reviews have concluded that existing drug use screening instruments are not appropriate for routine use in primary ...

Editor's Note: Assessment of Drug Use Disorders; Mitchell H. Katz, MD
Invited Commentary 
Michael K. Ong, MD, PhD

Tobacco use continues to be the leading preventable cause of mortality in the United States, despite a decrease in the overall prevalence of cigarette smoking. In this issue of JAMA Internal Medicine, Siegel et al1 report that cigarette smoking continues to be the attributable cause of ...

Invited Commentary 
Hilary J. Mosher, MFA, MD; Peter J. Kaboli, MD, MS

For some years, medical students at our institution have started orientation with a team-building exercise. Using paper, rubber bands, paper clips, popsicle sticks, and drinking straws, groups of 5 students are instructed to build a contraption to safely transport a raw egg from an atrium balcony to the ...

Editor's Note 
Mitchell H. Katz, MD

This Editor’s Note discusses the use of a new brief screening instrument for drug use disorders that can be used in the primary care setting.

Research Letter 
Pranav Kansara, MD, MS; Kristi Jackson, BS; Robert Dressler, MD; Henry Weiner, MD; Roger Kerzner, MD; William S. Weintraub, MD; Andrew Doorey, MD

This study used the current American Heart Association guidelines to determine whether telemetry alarms affect patient management and found that, even with the alarms designated as emergency, there were few episodes of clinically important arrhythmias and change in patient management was uncommon.

Research Letter 
Rebecca L. Siegel, MPH; Eric J. Jacobs, PhD; Christina C. Newton, MSPH; Diane Feskanich, ScD; Neal D. Freedman, PhD; Ross L. Prentice, PhD; Ahmedin Jemal, DVM, PhD

This study estimated the number of deaths attributable to cigarette smoking for 12 smoking-related cancers and found that continued progress in reducing cancer mortality requires more comprehensive tobacco control.

Invited Commentary: Tobacco Cessation; Michael K. Ong, MD, PhD
Perspective 
Shunichi Nakagawa, MD

After long training years in both general surgery and internal medicine, I recently became an attending physician in palliative medicine. One thing has become increasingly clear each day as I conduct family meetings and teach trainees how to break bad news. Palliative care, traditionally thought of as a ...

Invited Commentary: Searching for Joy in Residency by Listening to Our Patients; Blake Charlton, MD; Rachel J. Stern, MD
Teachable Moment 
Sanjiv M. Baxi, MS, MD, MPH; Joshua R. Lakin, MD
Invited Commentary: The Conundrum of Unnecessary Preoperative Testing; Gerald W. Smetana, MD

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