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 Showing 21-40 of 50 Articles
Original Investigation 
Michael E. Johansen, MD, MS; Caroline Richardson, MD
Includes: Supplemental Content

Importance  Therapeutic substitution offers potential to decrease pharmaceutical expenditures and potentially improve the efficiency of the health care system.

Objective  To estimate potential savings through therapeutic substitution in terms of both overall and out-of-pocket expenditures of branded drugs when a generic in the same class with ...

Editorial: Promise and Peril for Generic Drugs; Joshua M. Sharfstein, MD; Jeremy Greene, MD, PhD
Original Investigation 
James S. Yeh, MD, MPH; Jessica M. Franklin, PhD; Jerry Avorn, MD; Joan Landon, MPH; Aaron S. Kesselheim, MD, JD, MPH

Importance  Pharmaceutical industry payments to physicians may affect prescribing practices and increase costs if more expensive medications are prescribed.

Objective  Determine the association between industry payments to physicians and the prescribing of brand-name as compared with generic statins for lowering cholesterol.

Design, Setting, and Participants  ...

Editorial: Promise and Peril for Generic Drugs; Joshua M. Sharfstein, MD; Jeremy Greene, MD, PhD
Editor's Note 
Mitchell H. Katz, MD

Recurrent Staphylococcus aureus infections are a major problem. In their report on an intensive environmental investigation of the homes of persons diagnosed with community-acquired methicillin-resistant S aureus (MRSA) published in this issue of JAMA Internal Medicine, Knox and colleagues1 found that the clinical isolate that caused ...

Editor's Note 
Joseph S. Ross, MD, MHS

Generic drugs are substantially less expensive than brand-name drugs but equally effective. The surest path to generic medication use is for physicians (or other clinicians) to use generic drug names when prescribing. However, many physicians still write prescriptions using brand names, sometimes for no other reason than the ...

Challenges in Clinical Electrocardiography 
Bhaskar Bhardwaj, MD; Devika Kapuria, MD; Shariq Shamim, MD

A man in his 80s presented with weakness, fever, and chills of 1 week’s duration. His medical history was significant for severe aortic stenosis, heart failure with preserved ejection fraction, and end-stage renal disease requiring hemodialysis. His physical examination was unremarkable except for a hyperdynamic precordium, late peaking ...

Research Letter 
Aaron S. Kesselheim, MD, JD, MPH; Joshua J. Gagne, PharmD, ScD; Wesley Eddings, PhD; Jessica M. Franklin, PhD; Kathryn M. Ross, MBE; Lisa A. Fulchino, BA; Eric G. Campbell, PhD

This survey study investigates attitudes toward prescribing generic drugs among internists and specialists in endocrinology, hematology, and infectious diseases.

Editorial: Promise and Peril for Generic Drugs; Joshua M. Sharfstein, MD; Jeremy Greene, MD, PhD
Research Letter 
Mitesh S. Patel, MD, MBA, MS; Susan C. Day, MD, MPH; Scott D. Halpern, MD, PhD; C. William Hanson, MD; Joseph R. Martinez, BS; Steven Honeywell Jr, BS; Kevin G. Volpp, MD, PhD

This study examines prescription data from the University of Pennsylvania Health System outpatient clinics to compare generic medication prescription rates before and after a redesign of the electronic health record display defaults.

Editorial: Promise and Peril for Generic Drugs; Joshua M. Sharfstein, MD; Jeremy Greene, MD, PhD
Correction  FREE

In a Letter to the Editor by Ferric C. Fang titled “Toxin Immunoassays and Clostridium difficile Infection” published simultaneously online and in the March 1, 2016, print issue of JAMA Internal Medicine,1 the term “immunoassay” was incorrectly used in place of “assay.” This article was corrected ...

Teachable Moment 
Christina Hao Wang, MD; Blake Charlton, MD; Jeffrey Kohlwes, MD, MPH

This Teachable Moment questions the routine use of thickened liquids to prevent pneumonia in patients with dementia.

Original Investigation 
Corby K. Martin, PhD; Manju Bhapkar, MS; Anastassios G. Pittas, MD; Carl F. Pieper, DrPH; Sai Krupa Das, PhD; Donald A. Williamson, PhD; Tammy Scott, PhD; Leanne M. Redman, PhD; Richard Stein, PhD; Cheryl H. Gilhooly, PhD; Tiffany Stewart, PhD; Lisa Robinson, RD; Susan B. Roberts, PhD; for the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) Phase 2 Study Group
Includes: Supplemental Content

Importance  Calorie restriction (CR) increases longevity in many species and reduces risk factors for chronic diseases. In humans, CR may improve health span, yet concerns remain about potential negative effects of CR.

Objective  To test the effect of CR on mood, quality of life (QOL), sleep, ...

Invited Commentary: Obesity Management and Prevention; Tannaz Moin, MD, MBA, MSHS
Original Investigation 
Rena R. Wing, PhD; Deborah F. Tate, PhD; Mark A. Espeland, PhD; Cora E. Lewis, MD; Jessica Gokee LaRose, PhD; Amy A. Gorin, PhD; Judy Bahnson; Letitia H. Perdue, MS; Karen E. Hatley, MPH; Erica Ferguson, MSW; Katelyn R. Garcia, MS; Wei Lang, PhD; for the Study of Novel Approaches to Weight Gain Prevention (SNAP) Research Group
Includes: Supplemental Content

Importance  Weight gain occurs commonly in young adults and has adverse effects on health.

Objective  To compare 2 self-regulation interventions vs control in reducing weight gain in young adults over a mean follow-up of 3 years.

Design, Setting, and Participants  Randomized clinical trial in 2 ...

Invited Commentary: Obesity Management and Prevention; Tannaz Moin, MD, MBA, MSHS
Original Investigation 
Angel Y. S. Wong, BSc; Ian C. K. Wong, PhD; Celine S. L. Chui, MSc; Edwin H. M. Lee, FHKCPsych; W. C. Chang, FHKCPsych; Eric Y. H. Chen, MD; Wai K. Leung, MD; Esther W. Chan, PhD
Includes: Supplemental Content

Importance  There is a concern that Helicobacter pylori therapy containing clarithromycin might be associated with acute neuropsychiatric events.

Objective  To examine the association between H pylori therapy containing clarithromycin and acute neuropsychiatric events.

Design, Setting, and Participants  A self-controlled case series study was conducted using ...

Invited Commentary 
Tannaz Moin, MD, MBA, MSHS

More than one-third (34.9%) of the US population is obese,1 so it is critical to disseminate effective interventions to tackle this epidemic. Numerous weight management studies have been conducted, but the results have been mixed and interventions are often multifaceted, making it difficult to determine whether specific ...

Research Letter 
Xiaoyu Nie, MSPH; Soeren Mattke, MD, DSc; Zachary Predmore, BA; Hangsheng Liu, PhD

This study discusses the marked increase in the coding of risk from anesthesia for outpatient gastrointestinal procedures from 2005 to 2013.

Evidence to Practice 
Samia Mora, MD, MHS
Perspective 
Andre Kumar, MD; Nazima Allaudeen, MD

“New admission for NSTEMI. Please call the ER.” My eyebrows furrowed as I looked at my pager. It was shaping up to be a busy call day. I glanced through my new patient’s medical record and called the emergency department physician. It seemed straightforward: a 77-year-old man with ...

Original Investigation 
Yves Longtin, MD; Bianka Paquet-Bolduc, RN, MPA; Rodica Gilca, MD, PhD; Christophe Garenc, PhD; Elise Fortin, PhD; Jean Longtin, MD; Sylvie Trottier, MD, MSc; Philippe Gervais, MD; Jean-François Roussy, MD; Simon Lévesque, PhD; Debby Ben-David, MD; Isabelle Cloutier, BPharm; Vivian G. Loo, MD
Includes: Supplemental Content

Importance  Clostridium difficile infection (CDI) is a major cause of health care–associated infection worldwide, and new preventive strategies are urgently needed. Current control measures do not target asymptomatic carriers, despite evidence that they can contaminate the hospital environment and health care workers’ hands and potentially transmit C ...

Invited Commentary: Containing What Lies Under the Waterline; Alice Y. Guh, MD, MPH; L. Clifford McDonald, MD
Original Investigation 
Maricruz Rivera-Hernandez, PhD; Bryan Leyva, BA; Laura M. Keohane, PhD; Amal N. Trivedi, MD, MPH
Includes: Supplemental Content

Importance  Geographic, racial, and ethnic variations in quality of care and outcomes have been well documented among the Medicare population. Few data exist on beneficiaries living in Puerto Rico, three-quarters of whom enroll in Medicare Advantage (MA).

Objective  To determine the quality of care provided to ...

Invited Commentary: Disparities in Health Care in Puerto Rico vs the United States; Héctor M. Colón, PhD; Marizaida Sánchez-Cesareo, PhD

During the 2000s, the incidence of Clostridium difficile infection (CDI) increased dramatically, in large part due to the emergence of a hypervirulent strain, BI/NAP1/027, responsible for many hospital outbreaks in the United States. In 2011, C difficile accounted for 12% of all US health care–associated infections, surpassing Staphylococcus ...

Invited Commentary 
Héctor M. Colón, PhD; Marizaida Sánchez-Cesareo, PhD

In this issue of JAMA Internal Medicine, Rivera-Hernandez and colleagues1 report that Medicare Advantage (MA) enrollees in the territory of Puerto Rico receive substantially lower quality of care than white or Hispanic enrollees residing in the United States (50 states and Washington, DC). The authors found ...

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