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 Showing 21-40 of 73 Articles
Patrick G. O’Connor, MD, MPH; Robert J. Sokol, MD; Gail D’Onofrio, MD, MS
Substance use is highly prevalent, a substantial cause of morbidity and mortality and accounts for over $500 billion in economic costs in the United States annually. The 2012 National Survey on Drug Use and Health (NSDUH),1 which surveyed Americans 12 years or older, reported that 32% binge drink and nearly ...
Challenges in Clinical Electrocardiography 
David Snipelisky, MD; Maegan Roberts, MS; Joseph Blackshear, MD
Invited Commentary 
Takehiro Sugiyama, MD, PhD; Martin F. Shapiro, MD, PhD
Disparity in dietary quality is a public health concern in the United States. Excess caloric intake induces obesity and diabetes mellitus, which in turn cause cardiovascular diseases. Similarly, poorer dietary quality has been shown to affect health outcomes, whether directly or via intermediate chronic conditions such as hypertension and dyslipidemia. ...
Invited Commentary 
Kasia J. Lipska, MD, MHS
Older adults experience adverse drug events (ADEs) far more often than younger persons. The reasons for this include age-related decline in kidney and liver function, comorbidities, and the use of multiple medications. Oral glucose-lowering agents and insulin are implicated in one-quarter of emergency hospitalizations for ADEs among older US adults.1 ...
Invited Commentary 
Deborah Korenstein, MD; Cynthia D. Smith, MD
As the US health care system strives to improve value, there is near universal agreement that medical trainees must learn to reduce waste. The Accreditation Council for Graduate Medical Education has included skills in cost consciousness in the 2013 internal medicine reporting milestones,1 the Medicare Payment Advisory Commission has recommended ...
Invited Commentary 
Vinay Prasad, MD
Prostate-specific antigen (PSA) screening has been a disappointing public health strategy. The history of the PSA test will one day serve as a reminder that, although all of us in health care want to do everything possible to reduce the mortality of cancer, the early adoption of screening techniques on ...
Research Letter 
Aner Tal, PhD; Scott Zuckerman, MD; Brian Wansink, PhD
Television (TV) has generally been blamed for helping make Americans overweight1 owing to both its distracting influence and its encouragement of a sedentary lifestyle.2- 4 Indeed, a recent correlational analysis5 of dinner patterns illustrated that the frequency of TV viewing during dinner was 1 of the 2 largest correlates of ...
Topics: television; eating
Research Letter 
Jesse D. Sammon, DO; Daniel Pucheril, MD, MBA; Mireya Diaz, PhD; Adam S. Kibel, MD; Philip W. Kantoff, MD; Mani Menon, MD; Quoc-Dien Trinh, MD
Includes: Supplemental Content
Routine screening for prostate cancer using prostate-specific antigen (PSA) is a widely contested practice, and recommendations have recently changed dramatically. In October 2011, the US Preventative Services Task Force recommended against screening in any age group,1 yet current nationwide patterns of PSA screening are largely unknown. We sought to elucidate ...
Original Investigation 
Trisha M. Parekh, DO; Mukaila Raji, MD, MS; Yu-Li Lin, MS; Alai Tan, MD, PhD; Yong-Fang Kuo, PhD; James S. Goodwin, MD
Includes: Supplemental Content

Importance  Certain antimicrobial drugs interact with sulfonylureas to increase the risk of hypoglycemia.

Objective  To determine the risk of hypoglycemia and associated costs in older patients prescribed glipizide or glyburide who fill a prescription for an antimicrobial drug.

Design, Setting, and Participants  This was a ...

Original Investigation 
Brenda E. Sirovich, MD, MS; Rebecca S. Lipner, PhD; Mary Johnston, MS; Eric S. Holmboe, MD
Includes: Supplemental Content

Importance  Growing concern about rising costs and potential harms of medical care has stimulated interest in assessing physicians’ ability to minimize the provision of unnecessary care.

Objective  To assess whether graduates of residency programs characterized by low-intensity practice patterns are more capable of managing patients’ care ...

Original Investigation 
Dong D. Wang, MD, MSc; Cindy W. Leung, ScD; Yanping Li, PhD; Eric L. Ding, ScD; Stephanie E. Chiuve, ScD; Frank B. Hu, MD, PhD; Walter C. Willett, MD, DrPH
Includes: Supplemental Content

Importance  Many changes in the economy, policies related to nutrition, and food processing have occurred within the United States since 2000, and the net effect on dietary quality is not clear. These changes may have affected various socioeconomic groups differentially.

Objective  To investigate trends in dietary ...

Original Investigation 
Michael P. Bogenschutz, MD; Dennis M. Donovan, PhD; Raul N. Mandler, MD; Harold I. Perl, PhD; Alyssa A. Forcehimes, PhD; Cameron Crandall, MD, PhD; Robert Lindblad, MD; Neal L. Oden, PhD; Gaurav Sharma, PhD; Lisa Metsch, PhD; Michael S. Lyons, MD, MPH; Ryan McCormack, MD; Wendy Macias Konstantopoulos, MD, MPH; Antoine Douaihy, MD

Importance  Medical treatment settings such as emergency departments (EDs) present important opportunities to address problematic substance use. Currently, EDs do not typically intervene beyond acute medical stabilization.

Objective  To contrast the effects of a brief intervention with telephone boosters (BI-B) with those of screening, assessment, and ...

Vinod E. Nambudiri, MD, MBA
Topics: antibiotics
Pratik Patel, MD; Htin Aung, MD; Jason Post, MD
Original Investigation 
Björn Pasternak, MD, PhD; Henrik Svanström, MSc; Mads Melbye, MD, DrMedSci; Anders Hviid, MSc, DrMedSci
Includes: Supplemental Content

Importance  The β-blockers carvedilol and metoprolol succinate both reduce mortality in patients with heart failure (HF), but the comparative clinical effectiveness of these drugs is unknown.

Objective  To investigate whether carvedilol is associated with improved survival compared with metoprolol succinate.

Design, Setting, and Participants  Cohort ...

Case Report/Case Series 
Evangelia Liakoni, MD; Alexandra E. Rätz Bravo, PhD; Luigi Terracciano, MD; Markus Heim, MD; Stephan Krähenbühl, MD, PhD

Importance  Treatment with the new oral anticoagulant rivaroxaban can be associated with severe liver injury.

Observations  We report 2 patients with predominantly hepatocellular liver injury that had onset during treatment with rivaroxaban. Both were symptomatic, had massively elevated transaminase activity levels and hyperbilirubinemia, and fulfilled the ...

Editor's Note 
Joseph S. Ross, MD, MHS
Global funding for biomedical research now approaches $270 billion per year, nearly two-thirds of which comes from industry, including pharmaceutical, biotechnology, and medical device companies.1 While industry’s investment in research has spawned breakthroughs and innovations, these investments have also fueled concerns that industry-funded clinical trials are more likely to have ...
Invited Commentary 
Grace A. Lin, MD, MAS; R. Adams Dudley, MD, MBA
In recent years, there has been intense focus in the scientific community and media on the potential overuse of percutaneous coronary interventions (PCI) in patients with stable angina. Although PCI has proven to be effective in decreasing mortality rates among patients with acute myocardial infarction, it has not been shown ...
Invited Commentary 
Marie J. Hayes, PhD; Mark S. Brown, MD
The rapid acceleration of prescription opioid–related overdose deaths in the United States is correlated with the availability of stronger opioid medications, as well as a change in medical practice from withholding opioid medication because of dependence risk1 to treating patients with chronic pain with opioids. Subsequently, the pendulum of concern ...
Research Letter 
Nitin Roper, MD; Nasen Zhang, MD; Deborah Korenstein, MD
Industry-funded clinical trials are more likely to have favorable, proindustry results compared with nonindustry funded trials,1 but few studies have distinguished between industry funding in the context of industry collaboration in the design, analysis, or reporting of trials.2,3 For a sample of clinical trials published in high-impact journals, our objective ...

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