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 Showing 21-40 of 79 Articles
Evidence to Practice 
Jeffrey A. Tice, MD; Harinder S. Chahal, PharmD, MSc; Daniel A. Ollendorf, PhD

This evidence report on interferon-free therapy for chronic hepatitis C virus infection includes a systematic review of the literature, a cost-effectiveness model, and a budget impact assessment to support a December 2014 public meeting of the California Technology Assessment Forum.

This Viewpoint considers that breast density notification laws are unlikely to improve our understanding of breast cancer risk, screening, and diagnosis or to save lives and instead may result in substantial personal harms and societal costs.

Invited Commentary: Effect of Screening Mammography on Cancer Incidence and Mortality; Joann G. Elmore, MD, MPH; Ruth Etzioni, PhD
Original Investigation 
Bradley H. Crotty, MD, MPH; Jan Walker, RN, MBA; Meghan Dierks, MD; Lewis Lipsitz, MD; Jacqueline O’Brien, BS; Shira Fischer, MD, PhD; Warner V. Slack, MD; Charles Safran, MD, MS
Includes: Supplemental Content

Importance  Elderly patients often share control of their personal health information and decision making with family and friends when needed. Patient portals can help with information sharing, but concerns about privacy and autonomy of elderly patients remain. Health systems that implement patient portals would benefit from guidance ...

Invited Commentary: Information Sharing Preferences of Older Patients and Their Families; Pravene A. Nath, MD, MSE; Christopher D. Sharp, MD
Original Investigation 
Jade Q. Wu, MA; Erica R. Appleman, MA; Robert D. Salazar, MA; Jason C. Ong, PhD
Includes: Supplemental Content

Importance  Cognitive behavioral therapy for insomnia (CBT-I) is the most prominent nonpharmacologic treatment for insomnia disorders. Although meta-analyses have examined primary insomnia, less is known about the comparative efficacy of CBT-I on comorbid insomnia.

Objective  To examine the efficacy of CBT-I for insomnia comorbid with psychiatric ...

Invited Commentary: Treating Insomnia With Medical and Psychiatric Comorbidities; Michael A. Grandner, PhD, MTR; Michael L. Perlis, PhD
Original Investigation  FREE
Charles Harding, AB; Francesco Pompei, PhD; Dmitriy Burmistrov, PhD; H. Gilbert Welch, MD, MPH; Rediet Abebe, MASt; Richard Wilson, DPhil
Includes: Supplemental Content

Importance  Screening mammography rates vary considerably by location in the United States, providing a natural opportunity to investigate the associations of screening with breast cancer incidence and mortality, which are subjects of debate.

Objective  To examine the associations between rates of modern screening mammography and the ...

Invited Commentary: Effect of Screening Mammography on Cancer Incidence and Mortality; Joann G. Elmore, MD, MPH; Ruth Etzioni, PhD
Invited Commentary 
Pravene A. Nath, MD, MSE; Christopher D. Sharp, MD

The development of technology that drives and enables engagement with patients and their families is accelerating at an unprecedented pace. Demand is driven by patients seeking the best quality and experience as well as by health care organizations, payers, and policy makers in response to health care costs, ...

Invited Commentary 
Michael A. Grandner, PhD, MTR; Michael L. Perlis, PhD

Insomnia is a common condition. It is estimated that approximately 30% of the population experiences some symptom of insomnia, and approximately 5% to 15% of these individuals are likely to meet criteria for an insomnia disorder.1 Traditionally, insomnia was considered as either a primary disorder or secondary ...

Invited Commentary  FREE
Joann G. Elmore, MD, MPH; Ruth Etzioni, PhD

With increasing availability of massive quantities of health care data and advances in technology for data analyses, novel investigations of health delivery and outcomes are proliferating. In this issue of JAMA Internal Medicine, Harding et al1 investigate the health effects of screening mammography through the merging ...

Original Investigation 
Paul J. Christine, MPH; Amy H. Auchincloss, PhD; Alain G. Bertoni, MD, MPH; Mercedes R. Carnethon, PhD; Brisa N. Sánchez, PhD; Kari Moore, MS; Sara D. Adar, ScD; Tamara B. Horwich, MD, MS; Karol E. Watson, MD; Ana V. Diez Roux, MD, PhD
Includes: Supplemental Content

Importance  Neighborhood environments may influence the risk for developing type 2 diabetes mellitus (T2DM), but, to our knowledge, no longitudinal study has evaluated specific neighborhood exposures.

Objective  To determine whether long-term exposures to neighborhood physical and social environments, including the availability of healthy food and physical ...

Invited Commentary: Risk for Type 2 Diabetes Mellitus; Nancy E. Adler, PhD; Aric A. Prather, PhD
Original Investigation 
Nick Daneman, MD, MSc; Susan E. Bronskill, PhD; Andrea Gruneir, PhD; Alice M. Newman, MSc; Hadas D. Fischer, MD, MSC; Paula A. Rochon, MD, MPH; Geoffrey M. Anderson, MD, PhD; Chaim M. Bell, MD, PhD
Includes: Supplemental Content

Importance  Antibiotics are frequently and often inappropriately prescribed to patients in nursing homes. These antibiotics pose direct risks to recipients and indirect risks to others residing in the home.

Objective  To examine whether living in a nursing home with high antibiotic use is associated with an ...

Invited Commentary: Excessive Antibiotic Use in Nursing Homes; Lona Mody, MD, MSc; Christopher Crnich, MD, PhD
Original Investigation 
Danilo Di Bona, MD, PhD; Antonella Plaia, PhD; Maria Stefania Leto-Barone, MD, PhD; Simona La Piana, MD; Gabriele Di Lorenzo, MD
Includes: Supplemental Content

Importance  Randomized clinical trials (RCTs) and meta-analyses of sublingual immunotherapy (SLIT) for the treatment of seasonal allergic rhinoconjunctivitis (SARC) have shown a modest clinical benefit compared with placebo. Furthermore, indirect comparison by meta-analyses showed that subcutaneous immunotherapy is more effective than SLIT. Despite these data, SLIT has ...

Editor's Note: Caveat Emptor on Sublingual Immunotherapy; Patrick G. O’Malley, MD, MPH
Invited Commentary 
Nancy E. Adler, PhD; Aric A. Prather, PhD

Unprecedented increases in obesity in the United States have contributed to greater prevalence of diseases, such as type 2 diabetes mellitus (T2DM), which impair the quality of life and reduce the longevity of affected individuals, create demands on already-strained health care delivery systems, and generate greater health care ...

Invited Commentary 
Lona Mody, MD, MSc; Christopher Crnich, MD, PhD

In the United States, on any given day, approximately 1.4 million people reside in more than 15 000 nursing homes (NHs).1 As a testament to the burgeoning post–acute care population, approximately 3.3 million Medicare recipients are admitted to NHs for short stays each year, making NHs a crucial ...

Editor's Note 
Patrick G. O’Malley, MD, MPH

The synthesis of clinical trials of sublingual immunotherapy for grass pollen allergy by Di Bona et al1 in this issue indicates an unimpressive small effect, and the efficacy is even smaller in the United States compared with European populations. However, what was impressive is the 70.0% (1817 ...

Research Letter 
Rebecca Smith-Bindman, MD; Michelle Moghadassi, MPH; Richard T. Griffey, MD, MPH; Carlos A. Camargo Jr, MD, DrPH; John Bailitz, MD; Michael Beland, MD; Diana L. Miglioretti, PhD

This study reports that few computed tomographic examinations use an appropriately low dose of radiation among adults with suspected urolithiasis.

Research Letter 
Matthew J. Maurice, MD; Robert Abouassaly, MD, MS; Simon P. Kim, MD, MPH; Hui Zhu, MD, ScD

This study examined the use of active surveillance and its predictors in prostate cancer treatment, finding that its use is low and should increase to reduce the overtreatment of screening-detected prostate cancer.

Renu Mansukhani, MD

As I sat down for my visit with dad, I turned on my cell phone’s voice recorder. He did not notice. I did not want him to know that I was doing it because I did not want him to realize that I was starting to treat every ...

Original Investigation 
Leslee L. Subak, MD; Wendy C. King, PhD; Steven H. Belle, PhD, MScHyg; Jia-Yuh Chen, MS; Anita P. Courcoulas, MD, MPH; Faith E. Ebel, RD, MS, MPH; David R. Flum, MD, MPH; Saurabh Khandelwal, MD; John R. Pender, MD; Sheila K. Pierson, BS; Walter J. Pories, MD; Kristine J. Steffen, PharmD, PhD; Gladys W. Strain, PhD; Bruce M. Wolfe, MD; Alison J. Huang, MD, MAS
Includes: Supplemental Content

Importance  Among women and men with severe obesity, evidence for improvement in urinary incontinence beyond the first year after bariatric surgery–induced weight loss is lacking.

Objectives  To examine change in urinary incontinence before and after bariatric surgery and to identify factors associated with improvement and remission ...

Invited Commentary: Bariatric Surgery and Urinary Incontinence; Deborah L. Myers, MD
Original Investigation 
Zian H. Tseng, MD, MAS; Robert M. Hayward, MD; Nina M. Clark, BS; Christopher G. Mulvanny, MS; Benjamin J. Colburn, BA, BS; Philip C. Ursell, MD; Jeffrey E. Olgin, MD; Amy P. Hart, MD; Ellen Moffatt, MD
Includes: Supplemental Content

Importance  Interrogations and autopsies of sudden deaths with cardiac implantable electronic devices (CIEDs) are rarely performed. Therefore, causes of sudden deaths with these devices and the incidence of device failure are unknown.

Objective  To determine causes of death in individuals with CIEDs in a prospective autopsy ...

Editor's Note: Strengthening Medical Device Postmarket Safety Surveillance; Joseph S. Ross, MD, MHS
Original Investigation 
Elizabeth A. Regan, MD; David A. Lynch, MD; Douglas Curran-Everett, PhD; Jeffrey L. Curtis, MD; John H. M. Austin, MD; Philippe A. Grenier, MD; Hans-Ulrich Kauczor, MD; William C. Bailey, MD; Dawn L. DeMeo, MD; Richard H. Casaburi, PhD, MD; Paul Friedman, MD; Edwin J. R. Van Beek, MD; John E. Hokanson, PhD; Russell P. Bowler, MD; Terri H. Beaty, PhD; George R. Washko, MD; MeiLan K. Han, MD; Victor Kim, MD; Song Soo Kim, MD; Kunihiro Yagihashi, MD; Lacey Washington, MD; Charlene E. McEvoy, MD; Clint Tanner, MD; David M. Mannino, MD; Barry J. Make, MD; Edwin K. Silverman, MD; James D. Crapo, MD; for the Genetic Epidemiology of COPD (COPDGene) Investigators
Includes: Supplemental Content

Importance  Airflow obstruction on spirometry is universally used to define chronic obstructive pulmonary disease (COPD), and current or former smokers without airflow obstruction may assume that they are disease free.

Objective  To identify clinical and radiologic evidence of smoking-related disease in a cohort of current and ...

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