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Basic View | Expanded View
 Showing 21-40 of 53 Articles
Aileen P. Wright, BSc; William C. Becker, MD; Gordon D. Schiff, MD

This Viewpoint discusses strategies for prevent overprescribing of opioids while still effectively treating patients in chronic pain.

Original Investigation 
Tewodros Eguale, MD, PhD; David L. Buckeridge, MD, PhD; Aman Verma, PhD; Nancy E. Winslade, PharmD; Andrea Benedetti, PhD; James A. Hanley, PhD; Robyn Tamblyn, PhD
Includes: Supplemental Content

Importance  Off-label use of prescription drugs has been identified as an important contributor to preventable adverse drug events (ADEs) in children. Despite concerns regarding adverse outcomes, to date, no systematic investigation of the effects of off-label drug use in adult populations has been performed.

Objective  To ...

Invited Commentary: Turning Up the Heat on Off-Label Prescribing; Chester B. Good, MD, MPH; Walid F. Gellad, MD, MPH
Invited Commentary 
Chester B. Good, MD, MPH; Walid F. Gellad, MD, MPH

Yelling “Fire!” in a crowded theater without any imminent danger is an oft-cited example of free speech that is not protected. For many years, the US Food and Drug Administration (FDA) has prohibited the promotion of unapproved uses of drugs. This restriction has recently been challenged under the ...

Invited Commentary 
Prakash Deedwania, MD; Tushar Acharya, MD

There has been a significant increase in the use of mechanical circulatory support devices in recent years.1 This increase has been largely due to the availability of several new percutaneous ventricular assist devices (PVADs). Khera et al1 documented in this journal a 30-fold increase in the ...

Challenges in Clinical Electrocardiography 
Christopher L. Brown, MD; JoAnn Lindenfeld, MD; Marat Fudim, MD

A woman in her late teens with a 1-year history of viral cardiomyopathy presented with decompensated heart failure. The patient’s echocardiogram was notable for a left ventricular ejection fraction of 20% to 25%. Physical examination was notable for bibasilar crackles on lung auscultation and lower-extremity edema. The patient ...

Research Letter 
Taku Inohara, MD, PhD; Hiroaki Miyata, PhD; Ikuko Ueda, PhD; Yuichiro Maekawa, MD, PhD; Keiichi Fukuda, MD, PhD; Shun Kohsaka, MD, PhD

This study investigates the prognostic effect of intra-aortic balloon pump use in Japanese patients undergoing percutaneous coronary intervention for nonacute and acute indications.

Invited Commentary: Increased Use of Mechanical Circulatory Support Devices; Prakash Deedwania, MD; Tushar Acharya, MD
Correction  FREE

In the Original Investigation titled “Early Trends Among Seven Recommendations From the Choosing Wisely Campaign,”1 published online October 12, 2015, there was an error in the percentage given for ending utilization in the abstract. The last sentence of the Results section of the abstract should have read: ...

Michael Hochman, MD, MPH; Pieter A. Cohen, MD

This Viewpoint discusses concerns regarding recent guidelines issued by the Advisory Committee on Immunization Practices for pneumococcal vaccination in the elderly population.

Anne Schuchat, MD

This Viewpoint discusses the Advisory Committee on Immunization Practices' 2014 guidance for use of pneumococcal vaccines in elderly populations.

Original Investigation 
Jeremy B. Sussman, MD, MS; Eve A. Kerr, MD, MPH; Sameer D. Saini, MD, MS; Rob G. Holleman, MPH; Mandi L. Klamerus, MPH; Lillian C. Min, MD; Sandeep Vijan, MD, MS; Timothy P. Hofer, MD, MS
Includes: Supplemental Content

Importance  Older patients with diabetes mellitus receiving medical treatment whose blood pressure (BP) or blood glucose level are potentially dangerously low are rarely deintensified. Given the established risks of low blood pressure and blood glucose, this is a major opportunity to decrease medication harm.

Objective  To ...

Invited Commentary: Targeting Vascular Risk Factors in Older Adults; Enrico Mossello, MD, PhD
Case Report/Case Series 
Christopher R. Russo, MD; Terrence D. Welch, MD; Rajbir S. Sangha, MD; Mark L. Greenberg, MD

Importance  Cardiac arrhythmias are common causes of syncope. Brugada syndrome is an uncommon but serious genetic arrhythmia disorder that can be unmasked by medicines causing sodium channel blockade.

Observations  This report documents a case of Brugada syndrome and polymorphic ventricular tachycardia–ventricular fibrillation not initially recognized in ...

Invited Commentary 
Enrico Mossello, MD, PhD

For many years vascular disease prevention strategies have been focused on reducing undertreatment, often using a “one-size-fits-all” approach to increase patient adherence. The paradigm of this approach has been the proposal of a polypill targeting multiple vascular risk factors, a standard treatment aimed at maximizing vascular protection. Conversely, ...

Research Letter 
Tanner J. Caverly, MD, MPH; Angela Fagerlin, PhD; Brian J Zikmund-Fisher, PhD; Susan Kirsh, MD, MPH; Jeffrey Todd Kullgren, MD, MS, MPH; Katherine Prenovost, PhD; Eve A. Kerr, MD, MPH

This survey study of primary care physicians assessed perceived barriers to deintensifying treatment in patients with diabetes at risk for hypoglycemia.

Invited Commentary: Targeting Vascular Risk Factors in Older Adults; Enrico Mossello, MD, PhD
From The JAMA Network 
Karla Kerlikowske, MD

This summary and comparison of 2015 breast cancer screening recommendations from the American Cancer Society and US Preventive Services Task Force highlights the importance of a favorable benefit to harm ratio in the creation of mammography screening guidelines.

Janice K. Louie, MD, MPH; Harry Lampiris, MD

This short review of the literature on neuraminidase inhibitor effectiveness on influenza virus concludes that, while randomized clinical trials are lacking, observation data suggest benefit, especially in high-risk patients.

Teachable Moment 
Maen D. Abou Ziki, MD; David N. Podell, MD, PhD; Danise M. Schiliro, MD

This case report uses the example of a patient with scurvy to illustrate the importance of the basic history and physical examination, even in the age of more modern technological diagnostic techniques.

Original Investigation 
Hannah T. Neprash, BA; Michael E. Chernew, PhD; Andrew L. Hicks, MS; Teresa Gibson, PhD; J. Michael McWilliams, MD, PhD
Includes: Supplemental Content

Importance  Financial integration between physicians and hospitals may help health care provider organizations meet the challenges of new payment models but also may enhance the bargaining power of provider organizations, leading to higher prices and spending in commercial health care markets.

Objective  To assess the association ...

Invited Commentary: Hospital Acquisition of Physician Groups; James D. Reschovsky, PhD; Eugene Rich, MD
Invited Commentary 
James D. Reschovsky, PhD; Eugene Rich, MD

An important goal of the Affordable Care Act is to transform the US health care system from one characterized by high costs, poor quality, and fragmented care to one focused on comprehensive, coordinated, and efficient care. The Centers for Medicare & Medicaid Services (CMS) is working to meet ...

Research Letter 
Rafael D. Romo, PhD, RN; Sei J. Lee, MD, MAS; Yinghui Miao, MPH; W. John Boscardin, PhD; Alexander K. Smith, MD, MS, MPH

This study used Health and Retirement Study data to compare older adults’ predictions of their own survival with their actual survival.

This review of approvals of cancer drugs based on a surrogate end point by the US Food and Drug Administration assesses the postmarketing findings for overall survival.

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