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 Showing 21-40 of 49 Articles
Original Investigation 
Athanase Benetos, MD, PhD; Carlos Labat, BSc; Patrick Rossignol, MD, PhD; Renaud Fay, PharmD; Yves Rolland, MD, PhD; Filippo Valbusa, MD; Paolo Salvi, MD, PhD; Mauro Zamboni, MD, PhD; Patrick Manckoundia, MD, PhD; Olivier Hanon, MD, PhD; Sylvie Gautier, MD
Includes: Supplemental Content

Importance  Clinical evidence supports the beneficial effects of lowering blood pressure (BP) levels in community-living, robust, hypertensive individuals older than 80 years. However, observational studies in frail elderly patients have shown no or even an inverse relationship between BP and morbidity and mortality.

Objective  To assess ...

Original Investigation 
Nancy E. Avis, PhD; Sybil L. Crawford, PhD; Gail Greendale, MD; Joyce T. Bromberger, PhD; Susan A. Everson-Rose, PhD, MPH; Ellen B. Gold, PhD; Rachel Hess, MD; Hadine Joffe, MD, MSc; Howard M. Kravitz, DO, MPH; Ping G. Tepper, PhD; Rebecca C. Thurston, PhD; for the Study of Women’s Health Across the Nation (SWAN)

Importance  The expected duration of menopausal vasomotor symptoms (VMS) is important to women making decisions about possible treatments.

Objectives  To determine total duration of frequent VMS (≥6 days in the previous 2 weeks) (hereafter total VMS duration) during the menopausal transition, to quantify how long frequent ...

Invited Commentary: Vasomotor Symptom Duration; Gloria Richard-Davis, MD; JoAnn E. Manson, MD, DrPH
Original Investigation 
Matthew Miller, MD, ScD; Catherine W. Barber, MPA; Sarah Leatherman, PhD; Jennifer Fonda, BS; John A. Hermos, MD; Kelly Cho, PhD; David R. Gagnon, MD
Includes: Supplemental Content

Importance  The unprecedented increase in unintentional overdose events that has occurred in tandem with escalating sales of prescription opioids over the past 2 decades has raised concerns about whether the therapeutic use of opioids has contributed to increases in overdose injury. Few controlled studies have examined the ...

Original Investigation 
David S. Black, PhD, MPH; Gillian A. O’Reilly, BS; Richard Olmstead, PhD; Elizabeth C. Breen, PhD; Michael R. Irwin, MD
Includes: Supplemental Content

Importance  Sleep disturbances are most prevalent among older adults and often go untreated. Treatment options for sleep disturbances remain limited, and there is a need for community-accessible programs that can improve sleep.

Objective  To determine the efficacy of a mind-body medicine intervention, called mindfulness meditation, to ...

Invited Commentary: Mindfulness of Later-Life Sleep Quality; Adam P. Spira, PhD
Original Investigation 
Amanda R. Markovitz, MPH; Jeffrey A. Alexander, PhD; Paula M. Lantz, PhD; Michael L. Paustian, PhD
Includes: Supplemental Content

Importance  The patient-centered medical home (PCMH) model of primary care is being implemented in a wide variety of socioeconomic contexts, yet there has been little research on whether its effects differ by context. Clinical preventive service use, including cancer screening, is an important outcome to assess the ...

Invited Commentary 
Adam P. Spira, PhD
Older adults commonly report disturbed sleep, and an expanding literature suggests that poor sleep increases the risk of adverse health outcomes.1 In this issue of JAMA Internal Medicine, Black et al2 present a randomized clinical trial (RCT) among adults 55 years and older with moderately disturbed sleep, comparing a sleep ...
Invited Commentary 
Gloria Richard-Davis, MD; JoAnn E. Manson, MD, DrPH
Vasomotor symptoms (VMS) affect up to 80% of menopausal women and are the most common reason these women seek treatment. Approximately 60% of midlife women seek medical care or advice at least once because of VMS,1 which adversely affect quality of life in domains that include work, social and leisure ...
Editor's Note 
Mitchell H. Katz, MD
All patients would benefit from having a patient-centered medical home. However, Markovitz and colleagues1 show that low-income patients may benefit more than others. Using data from adult primary care physician practices in Michigan, they show that the increases in cancer screening associated with patient-centered medical homes are greater for low-income ...
Editor's Note 
Mitchell H. Katz, MD
JAMA Internal Medicine has run a series of articles on the dangers of prescription opioids for the treatment of chronic pain.1,2 The best solution is to avoid prescribing opioids for chronic pain because there is no high-quality evidence that they are effective for this indication, and the risk of adverse ...
Research Letter 
Paolo Goffredo, MD; Samantha M. Thomas, MB; Michaela A. Dinan, PhD; Jennifer M. Perkins, MD; Sanziana A. Roman, MD; Julie A. Sosa, MD
Based on current guidelines, adjuvant radioactive iodine (RAI) therapy is not recommended for localized papillary thyroid tumors measuring 1 cm or less, medullary thyroid cancer (MTC), and anaplastic thyroid cancer (ATC).1- 3 Nevertheless, previous studies have reported the use of RAI in the treatment of these cancers.
Teachable Moment 
Raed A. Joundi, DPhil, MD, PGY-1; Brian M. Wong, MD; Jerome A. Leis, MD, MSc
Editorial  FREE
Robert Steinbrook, MD; Rita F. Redberg, MD, MSc
In this issue of JAMA Internal Medicine, we publish a report1 that highlights an important area for improved public reporting of clinical trials and enhanced transparency at the US Food and Drug Administration (FDA). Seife1 identifies numerous instances in which the FDA found evidence of apparent research misconduct serious enough ...
Original Investigation  FREE
Charles Seife, MS
Includes: Supplemental Content

Importance  Every year, the US Food and Drug Administration (FDA) inspects several hundred clinical sites performing biomedical research on human participants and occasionally finds evidence of substantial departures from good clinical practice and research misconduct. However, the FDA has no systematic method of communicating these findings to ...

Editorial: Reporting Research Misconduct in the Literature; Robert Steinbrook, MD; Rita F. Redberg, MD, MSc
Original Investigation 
Anupam B. Jena, MD, PhD; Dana P. Goldman, PhD; Seth A. Seabury, PhD

Importance  Human papillomavirus (HPV) vaccination rates among US females remain low, in part because of concerns that HPV vaccination may promote unsafe sexual activity by lowering perceived risks of acquiring a sexually transmitted infection (STI).

Objective  To study whether HPV vaccination of females is associated with ...

Invited Commentary: HPV Vaccine and Sexual Activity; Robert A. Bednarczyk, PhD
Original Investigation 
Lauren E. Ferrante, MD; Margaret A. Pisani, MD, MPH; Terrence E. Murphy, PhD; Evelyne A. Gahbauer, MD, MPH; Linda S. Leo-Summers, MPH; Thomas M. Gill, MD

Importance  Little is known about functional trajectories of older persons in the year before and after admission to the intensive care unit (ICU) or how pre-ICU functional trajectories affect post-ICU functional trajectories and death.

Objectives  To characterize functional trajectories in the year before and after ICU ...

Invited Commentary 
Robert A. Bednarczyk, PhD
Compared with other routinely recommended adolescent vaccines (eg, diphtheria and tetanus toxoids and acellular pertussis [Tdap] vaccine and quadrivalent meningococcal conjugate [MCV4] vaccine), human papillomavirus (HPV) vaccine uptake has been lower, with only 57% of adolescent females and 35% of adolescent males initiating the 3-dose HPV vaccine series.1 Often, the ...
Invited Commentary 
Nicholas S. Downing, MD
After the US Food and Drug Administration (FDA) approves a new brand-name prescription drug, the drug is protected from generic competition by the combination of 2 market exclusivity mechanisms. Patents cover the intellectual property inherent in the design of a new drug, processes used in manufacturing the medication, and sometimes ...
Editor's Note 
Kenneth E. Covinsky, MD, MPH
When patients are in an intensive care unit (ICU), considerable attention is placed on physiological variables of illness. This novel article by Ferrante and colleagues1 establishes that we also need to be attentive to patient-centered measures of function as a fundamental measure of illness that must be assessed in all ...
Editor's Note 
Rita F. Redberg, MD, MSc
The Choosing Wisely campaign1 has ignited an international discussion of what medical practices should be done less frequently or not at all. Sixty professional societies have created Top Five lists of ways to eliminate waste in medical care. Because this is the first broad discussion of unnecessary care to include ...

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