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 Showing 21-40 of 84 Articles
Research Letter 
Ravi Gupta, BS, BA; Aaron S. Kesselheim, MD, JD, MPH; Nicholas Downing, MD; Jeremy Greene, MD, PhD; Joseph S. Ross, MD, MHS

This study uses US Food and Drug Administration data to identify approved generic drugs manufactured between September 30, 1984, and January 11, 2016 and compares the effects of number of generic drugs associated with brand-name drugs.

Research Letter 
Alan B. Zonderman, PhD; Nicolle A. Mode, MS; Ngozi Ejiogu, MD; Michele K. Evans, MD

This study uses data from the Healthy Aging in Neighborhoods of Diversity across the Life Span study to examine the contributions of sex, race, and socioeconomic differences to overall mortality in middle-aged adults.

Lydia A. Flier, MD; Christopher R. Henderson, MD, MPhil; Carolyn L. Treasure, MD

This Invited Commentary examines arguments in favor of discontinuing the Step 2 Clinical Skills Examination.

Neil Skolnik, MD

I am leaving a room where I had a discussion with a son and daughter who strongly desired that their 94-year-old mother with severe dementia, chronic obstructive pulmonary disease, a history of heart disease with triple-bypass surgery, and 2 repaired hip fractures continue her statin and all her ...

Teachable Moment 
Ploa Desforges, MD; Todd C. Lee, MD, MPH; Emily G. McDonald, MD, MSc

This Teachable Moment discusses nonpharmacologic interventions prior to prescribing quetiapine, benzodiazepines, or sedative hypnotic drugs for the short-term treatment of insomnia in older adult patients.

Lisa M. Schwartz, MD, MS; Steven Woloshin, MD, MS
Includes: Supplemental Content

Cancer centers advertise to reach patients and their families in a very competitive market. Patients often have dangerous cancers and face toxic treatments and the advertisements offer hope. But the hope can—and often does—morph into hype. After all, this is advertising. Medicine has long been ambivalent about advertising ...

Original Investigation 
Anupam B. Jena, MD, PhD; Andrew R. Olenski, BS; Daniel M. Blumenthal, MD, MBA
Includes: Supplemental Content

Importance  Limited evidence exists on salary differences between male and female academic physicians, largely owing to difficulty obtaining data on salary and factors influencing salary. Existing studies have been limited by reliance on survey-based approaches to measuring sex differences in earnings, lack of contemporary data, small sample ...

Invited Commentary: Equal Pay for Equal Work for Physicians; Vineet M. Arora, MD, MAPP
Original Investigation 
Eric C. Sun, MD, PhD; Beth Darnall, PhD; Laurence C. Baker, PhD; Sean Mackey, MD, PhD
Includes: Supplemental Content

Importance  Chronic opioid use imposes a substantial burden in terms of morbidity and economic costs. Whether opioid-naive patients undergoing surgery are at increased risk for chronic opioid use is unknown, as are the potential risk factors for chronic opioid use following surgery.

Objective  To characterize the ...

Original Investigation 
Michaël Chassé, MD, PhD, FRCPC; Alan Tinmouth, MD, MSc, FRCPC; Shane W. English, MD, MSc, FRCPC; Jason P. Acker, MBA, PhD; Kumanan Wilson, MD, FRCPC; Greg Knoll, MD, MSc, FRCPC; Nadine Shehata, MD, MSc, FRCPC; Carl van Walraven, MD, MSc, FRCPC; Alan J. Forster, MD, MSc, FRCPC; Timothy Ramsay, PhD; Lauralyn A. McIntyre, MD, MSc, FRCPC; Dean A. Fergusson, MHA, PhD
Includes: Supplemental Content

Importance  While red blood cells (RBCs) are administered to improve oxygen delivery and patient outcomes, they also have been associated with potential harm. Unlike solid organ transplantation, the clinical consequences of donor characteristics on recipients have not been evaluated in transfusion medicine.

Objective  To analyze the ...

Invited Commentary: Blood Donor Demographics and Transfusion Recipient Survival; Harvey G. Klein, MD
Invited Commentary 
Vineet M. Arora, MD, MAPP
Invited Commentary 
Harvey G. Klein, MD

Blood for transfusion is a drug or, more specifically, a biological medicine.1 The US Food and Drug Administration regulates blood for purity, potency, and safety under the Food, Drug, and Cosmetic Act of 1938. Regulatory authorities in most developed countries prescribe blood collection, storage, testing, labeling, and ...

Joshua R. Lakin, MD; Susan D. Block, MD; J. Andrew Billings, MD; Luca A. Koritsanszky, MPH; Rebecca Cunningham, MD; Lisa Wichmann, RN, MS, ACM, NC-BC; Doreen Harvey, BSN, RN, CCM, NC-BC; Jan Lamey, MS; Rachelle E. Bernacki, MD, MS
Includes: Supplemental Content

Importance  The Institute of Medicine recently called for systematic improvements in clinician-led conversations about goals, values, and care preferences for patients with serious and life-threatening illnesses. Studies suggest that these conversations are associated with improved outcomes for patients and their families, enhanced clinician satisfaction, and lower health ...

Challenges in Clinical Electrocardiography 
Matthew Jackson, MBChB; Muhammad Muzaffar Mahmood, MBBS, MRCP

A woman in her 70s presented with sudden-onset central chest pain. She was known to have hypertension, which was well controlled with amlodipine maleate therapy. She sought medical help within 2 hours of the onset of pain and an electrocardiogram (ECG) was performed (Figure 1). No ...

Research Letter 
Laura B. Vater, MPH; Julie M. Donohue, PhD; Seo Young Park, PhD; Yael Schenker, MD, MAS

This analysis examines the effect of advertising by cancer centers on the quality and costs of cancer care in the United States.

Editorial: Cancer Center Advertising; Lisa M. Schwartz, MD, MS; Steven Woloshin, MD, MS
Research Letter 
Todd C. Lee, MD, MPH; Ploa Desforges, MD; Jennifer Murray, MScPH; Ramy R. Saleh, MD; Emily G. McDonald, MD, MSc

This study describes safety and efficacy in the use of quetiapine in a prospective cohort of inpatients and the proportion of in-hospital use that is perpetuated on discharge.

Editorial  FREE
Rita F. Redberg, MD, MSc

I want to thank all of our readers, authors, reviewers, and of course my incredible team of editors for another wonderful and enjoyable year. We are also delighted to have an active group of JAMA Internal Medicine Editorial Fellows and Elective Residents from University of California, San Francisco ...

Original Investigation 
Karen R. Siegel, PhD; Kai McKeever Bullard, PhD; Giuseppina Imperatore, MD; Henry S. Kahn, MD; Aryeh D. Stein, PhD; Mohammed K. Ali, MBChB; K. M. Narayan, MD
Includes: Supplemental Content

Importance  Food subsidies are designed to enhance food availability, but whether they promote cardiometabolic health is unclear.

Objective  To investigate whether higher consumption of foods derived from subsidized food commodities is associated with adverse cardiometabolic risk among US adults.

Design, Setting, and Participants  Cross-sectional analysis ...

Invited Commentary: How Society Subsidizes Big Food and Poor Health; Raj Patel, PhD
Original Investigation 
Dong D. Wang, MD, MSc; Yanping Li, PhD; Stephanie E. Chiuve, ScD; Meir J. Stampfer, MD, DrPH; JoAnn E. Manson, MD, DrPH; Eric B. Rimm, ScD; Walter C. Willett, MD, DrPH; Frank B. Hu, MD, PhD
Includes: Supplemental Content

Importance  Previous studies have shown distinct associations between specific dietary fat and cardiovascular disease. However, evidence on specific dietary fat and mortality remains limited and inconsistent.

Objective  To examine the associations of specific dietary fats with total and cause-specific mortality in 2 large ongoing cohort studies....

Original Investigation 
Hilde A. M. Kooistra, PhD; Agneta H. Calf, MD; Margriet Piersma-Wichers, MD; Hanneke C. Kluin-Nelemans, PhD; Gerbrand J. Izaks, PhD; Nic J. G. M. Veeger, PhD; Karina Meijer, PhD
Includes: Supplemental Content

Importance  Previous studies have shown that, despite the higher risk of bleeding, the elderly still benefit from taking anticoagulants if they have a stringent indication. However, owing to the relatively low number of patients older than 90 years in these studies, it is unknown whether this benefit ...

Editor's Note: Anticoagulation in the Very Old; Anna L. Parks, MD; Kenneth E. Covinsky, MD
Original Investigation 
Hui-Jie Zhang, MD, PhD; Jiang He, MD, PhD; Ling-Ling Pan, MD, PhD; Zhi-Min Ma, MD, PhD; Cheng-Kun Han, MD; Chung-Shiuan Chen, MS; Zheng Chen, MD; Hai-Wei Han, MD; Shi Chen, MD; Qian Sun, MD; Jun-Feng Zhang, MD; Zhi-Bin Li, MD; Shu-Yu Yang, MD, PhD; Xue-Jun Li, MD, PhD; Xiao-Ying Li, MD, PhD
Includes: Supplemental Content

Importance  Nonalcoholic fatty liver disease (NAFLD) is a prevalent risk factor for chronic liver disease and cardiovascular disease.

Objective  To compare the effects of moderate and vigorous exercise on intrahepatic triglyceride content and metabolic risk factors among patients with NAFLD.

Design, Setting, and Participants  In ...

Invited Commentary: Exercise for Nonalcoholic Fatty Liver Disease; Stacey Prenner, MD; Mary E. Rinella, MD

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