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Basic View | Expanded View
 Showing 1-20 of 53 Articles
Viewpoint  FREE
Marion Nestle, PhD, MPH

This Viewpoint emphasizes that nutrition researchers and professional societies need to recognize the influence of food-industry sponsorship, take steps to control its effects, and ensure that sponsored studies promote public health.

Original Investigation 
Harinder S. Chahal, PharmD, MSc; Elliot A. Marseille, PhD; Jeffrey A. Tice, MD; Steve D. Pearson, MD, MSc; Daniel A. Ollendorf, PhD; Rena K. Fox, MD; James G. Kahn, MD, MPH
Includes: Supplemental Content

Importance  Novel treatments for hepatitis C virus (HCV) infection are highly efficacious but costly. Thus, many insurers cover therapy only in advanced fibrosis stages. The added health benefits and costs of early treatment are unknown.

Objective  To assess the cost-effectiveness of (1) treating all patients with ...

Invited Commentary: Treatment of Hepatitis C Virus Infection in Real Life; Hal F. Yee Jr, MD, PhD
Invited Commentary 
Vincent Mor, PhD; Momotazur Rahman, PhD; John McHugh, MBA

The Centers for Medicare & Medicaid Services have introduced the Medicare Spending per Beneficiary demonstration to bring more accountability to patient care by focusing hospitals on lowering spending across the continuum of care. This metric reflects consensus from policymakers and health care professionals that hospitals and health systems ...

Invited Commentary 
Hal F. Yee Jr, MD, PhD

The US Food and Drug Administration approved the first daily oral antiviral for the treatment of hepatitis C virus (HCV) infection in November 2013. This and subsequent antivirals represented a marked improvement compared with the prior regimen of ribavirin and injectable interferon. However, the extraordinary costs of the ...

Challenges in Clinical Electrocardiography 
Matthew William Paul Jackson, MBChB; Robin James Taylor, MBChB, MRCP

An elderly woman presented with gross peripheral edema extending to the abdominal wall 2 months after a tissue aortic valve replacement for severe symptomatic aortic stenosis. Her immediate postoperative recovery had been complicated by developing atrial fibrillation associated with an uncontrolled ventricular rate, which was treated with bisoprolol ...

Research Letter 
Anup Das, BA; Edward C. Norton, PhD; David C. Miller, MD, MPH; Lena M. Chen, MD, MS

This CMS database study suggests that hospitals that can reduce postdischarge spending may perform better on CMS’ new spending measure.

Invited Commentary: Medicare Beneficiaries’ Postacute Care Discharge Disposition; Vincent Mor, PhD; Momotazur Rahman, PhD; John McHugh, MBA
Research Letter 
Lindsay E. Jubelt, MD, MS; Keith S. Goldfeld, DrPH, MS, MPA; Wei-yi Chung, MS, ASN; Saul B. Blecker, MD, MHS; Leora I. Horwitz, MD, MHS

This review of Medicare claims data assesses the effect of the Bundled Payment for Care Improvement model on rates of patient discharge to postacute care facilities.

Invited Commentary: Medicare Beneficiaries’ Postacute Care Discharge Disposition; Vincent Mor, PhD; Momotazur Rahman, PhD; John McHugh, MBA
Research Letter 
Alberto Maino, MD; Bob Siegerink, PhD; Ale Algra, MD, PhD; Flora Peyvandi, MD, PhD; Frits R. Rosendaal, MD, PhD

This Research Letter reports the long-term mortality and subtype-specific morbidity in young women surviving myocardial infarction or ischemic stroke.

Teachable Moment 
Nathan Handley, MD; Alon Unger, MD

This case report uses the example of an older woman with paronychia to discuss judicious use of antibiotics for skin conditions in the outpatient setting.

Original Investigation 
Albert Y. Liu, MD, MPH; Stephanie E. Cohen, MD, MPH; Eric Vittinghoff, PhD; Peter L. Anderson, PharmD; Susanne Doblecki-Lewis, MD; Oliver Bacon, MD, MPH; Wairimu Chege, MD, MPH; Brian S. Postle, BS; Tim Matheson, PhD; K. Rivet Amico, PhD; Teri Liegler, PhD; M. Keith Rawlings, MD; Nikole Trainor, MPH; Robert Wilder Blue, MSW; Yannine Estrada, PhD; Megan E. Coleman, FNP; Gabriel Cardenas, MPH; Daniel J. Feaster, PhD; Robert Grant, MD, MPH; Susan S. Philip, MD, MPH; Richard Elion, MD; Susan Buchbinder, MD; Michael A. Kolber, PhD, MD
Includes: Supplemental Content

Importance  Several randomized clinical trials have demonstrated the efficacy of preexposure prophylaxis (PrEP) in preventing human immunodeficiency virus (HIV) acquisition. Little is known about adherence to the regimen, sexual practices, and overall effectiveness when PrEP is implemented in clinics that treat sexually transmitted infections (STIs) and community-based ...

Invited Commentary: Optimizing Delivery of Preexposure Prophylaxis; Raphael J. Landovitz, MD, MSc
Invited Commentary 
Raphael J. Landovitz, MD, MSc

Preexposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) infection—administering a daily tablet of a US Food and Drug Administration (FDA)-approved HIV antiretroviral fixed-dose combination of tenofovir disoproxil fumarate and emtricitabine (TDF/FTC) (Truvada; Gilead Sciences, Inc) to high-risk uninfected individuals—has galvanized supporters and opponents.

Editor's Note 
Kenneth E. Covinsky, MD

When I was an intern, we frequently placed urinary catheters in hospitalized patients. For some diagnoses, like congestive heart failure, we believed placement of a urinary catheter was almost mandatory to accurately measure fluid output during diuresis. We were well meaning and thought more monitoring of intake and ...

Research Letter 
Jerome A. Leis, MD, MSc; Carla Corpus, RN, CIC; Armin Rahmani; Barbara Catt, CIC; Brian M. Wong, MD; Sandra Callery, RN, MHSc, CIC; Mary Vearncombe, MD

Impacts of a Medical Directive for Urinary Catheter Removal by Nurses

Editor's Note: Risks Associated With Catheters; Kenneth E. Covinsky, MD
Research Letter 
Aditya S. Khanna, PhD; Stuart Michaels, PhD; Britt Skaathun, MPH; Ethan Morgan, BS; Keith Green, MSW; Lindsay Young, PhD; John A. Schneider, MD, MPH; for the UConnect Study Team

This cohort study of the uConnect population-based sample of black men who have sex with men discusses the HIV prevention potential of a preexposure prophylaxis approved by the US Food and Drug Administration in 2012.

Invited Commentary: Optimizing Delivery of Preexposure Prophylaxis; Raphael J. Landovitz, MD, MSc
Martin Marshall, MD; Andrew B. Bindman, MD

This Viewpoint addresses common challenges in the United States and England of increasing health care value by improving quality and discusses how governments have a central role in determining the public-private balance of their health systems.

Teachable Moment 
Tyson A. Oberndorfer, MD, MS; Debra L. Anoff, MD; Heidi L. Wald, MD

This Teachable Moment describes the case of a man with metastatic masses in his brain who underwent surgery and died shortly thereafter and calls for more careful consideration of treatment options.

Editor's Note 
Mitchell H. Katz, MD

Persons with serious mental illness have a high rate of early mortality. Contributing factors include increased prevalence of smoking and other forms of substance abuse, sedentary lifestyle, and adverse effects of psychotropic medication use. These greater risks for premature death are compounded by poor access to medical care. ...

Special Communication 
Daniel J. Morgan, MD, MS; Sanket S. Dhruva, MD; Scott M. Wright, MD; Deborah Korenstein, MD

Importance  Overuse of medical care, consisting primarily of overdiagnosis and overtreatment, is a common clinical problem.

Objectives  To identify and highlight articles published in 2014 that are most likely to influence medical overuse, organized into the categories of overdiagnosis, overtreatment, and methods to avoid overuse, and ...

Research Letter 
Christina Mangurian, MD; John W. Newcomer, MD; Eric Vittinghoff, PhD; Jennifer M. Creasman, MSPH; Penelope Knapp, MD; Elena Fuentes-Afflick, MD, MPH; Dean Schillinger, MD

This retrospective cohort study analyzes diabetes screening prevalence and predictors of screening among adults in the California public mental health care system with severe mental illness taking antipsychotic medications.

Research Letter 
Nihar R. Desai, MD, MPH; Craig S. Parzynski, MS; Harlan M. Krumholz, MD, SM; Karl E. Minges, MPH; John C. Messenger, MD; Brahmajee K. Nallamothu, MD, MPH; Jeptha P. Curtis, MD

This Research Letter reports heterogeneity in institutional review of percutaneous coronary intervention appropriateness and calls for the identification of effective strategies to improve institutional review.

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