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Editor's Note | June 17, 2013 
Symptom Number and Severity as a Sign of Emotional Distress in Patients With Cardiovascular Disease :  Comment on: “Somatic Symptoms in Patients With Coronary Heart Disease”
Patrick G. O’Malley, MD, MPH
The study by Kohlmann et al corroborates the finding that somatic symptom burden (defined as the number and severity of symptoms) is ...
JAMA Intern Med. Published online June 17, 2013. doi:10.1001/jamainternmed.2013.6630
Original Investigation | June 17, 2013 
Changes in Red Meat Consumption and Subsequent Risk of Type 2 Diabetes Mellitus:  Three Cohorts of US Men and Women
An Pan, PhD; Qi Sun, MD, ScD; Adam M. Bernstein, MD, ScD; JoAnn E. Manson, MD, DrPH; Walter C. Willett, MD, DrPH; Frank B. Hu, MD, PhD
ImportanceImportance Red meat consumption has been consistently associated with an increased risk of type 2 diabetes mellitus (T2DM). However, whether changes in ...
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JAMA Intern Med. Published online June 17, 2013. doi:10.1001/jamainternmed.2013.6633
RESEARCH LETTER | June 17, 2013 
ω-3 Fatty Acid Supplements for Secondary Prevention of Cardiovascular Disease: From “No Proof of Effectiveness” to “Proof of No Effectiveness”
Andrea Messori, PharmD; Valeria Fadda, PharmD; Dario Maratea, PharmD; Sabrina Trippoli, PharmD
In patients who have experienced cardiovascular events, ω-3 fatty acid supplements do not seem to be beneficial.1 However, there is not universal ...
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JAMA Intern Med. Published online June 17, 2013. doi:10.1001/jamainternmed.2013.6638
RESEARCH LETTER | June 17, 2013 
The Effect of Treatment History on Therapeutic Outcome: An Experimental Approach
Simon Kessner; Katja Wiech, PhD; Katarina Forkmann, MS; Markus Ploner, MD; Ulrike Bingel, MD
Therapeutic context can critically determine treatment outcome.1 Prior experience with a treatment is an important contextual factor that has been shown to ...
JAMA Intern Med. Published online June 17, 2013. doi:10.1001/jamainternmed.2013.6705
RESEARCH LETTER | June 17, 2013 
Somatic Symptoms in Patients With Coronary Heart Disease: Prevalence, Risk Factors, and Quality of Life
Sebastian Kohlmann, MSc; Benjamin Gierk, MSc; Melanie Hümmelgen, MD; Stefan Blankenberg, MD; Bernd Löwe, MD
Abroad spectrum of somatic symptoms is common in primary care, and more than half of medical visits are due to nonspecific symptoms ...
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JAMA Intern Med. Published online June 17, 2013. doi:10.1001/jamainternmed.2013.6835
Original Investigation | June 17, 2013 
Differences in Human Immunodeficiency Virus Care and Treatment Among Subpopulations in the United States
H. Irene Hall, PhD; Emma L. Frazier, PhD; Philip Rhodes, PhD; David R. Holtgrave, PhD; Carolyn Furlow-Parmley, PhD; Tian Tang, MS; Kristen Mahle Gray, MPH; Stacy M. Cohen, MPH; Jonathan Mermin, MD; Jacek Skarbinski, MD
ImportanceImportance Early diagnosis of human immunodeficiency virus (HIV) infection, prompt linkage to and sustained care, and antiretroviral therapy are associated with reduced ...
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JAMA Intern Med. Published online June 17, 2013. doi:10.1001/jamainternmed.2013.6841
Special Article | June 17, 2013 
Delivery System Integration and Health Care Spending and Quality for Medicare Beneficiaries
J. Michael McWilliams, MD, PhD; Michael E. Chernew, PhD; Alan M. Zaslavsky, PhD; Pasha Hamed, MA; Bruce E. Landon, MD, MBA, MSc
Includes: Supplemental Content
ImportanceImportance The Medicare accountable care organization (ACO) programs rely on delivery system integration and health care provider risk sharing to lower spending ...
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JAMA Intern Med. Published online June 17, 2013. doi:10.1001/jamainternmed.2013.6886
Original Investigation | June 17, 2013  FREE
Epidemiology of Community-Associated Clostridium difficile Infection, 2009 Through 2011
Amit S. Chitnis, MD, MPH; Stacy M. Holzbauer, DVM, MPH; Ruth M. Belflower, RN, MPH; Lisa G. Winston, MD; Wendy M. Bamberg, MD; Carol Lyons, MPH; Monica M. Farley, MD; Ghinwa K. Dumyati, MD; Lucy E. Wilson, MD, ScM; Zintars G. Beldavs, MS; John R. Dunn, DVM, PhD; L. Hannah Gould, PhD, MS; Duncan R. MacCannell, PhD; Dale N. Gerding, MD; L. Clifford McDonald, MD; Fernanda C. Lessa, MD, MPH
ImportanceImportance Clostridium difficile infection (CDI) has been increasingly reported among healthy individuals in the community. Recent data suggest that community-associated CDI represents ...
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JAMA Intern Med. Published online June 17, 2013. doi:10.1001/jamainternmed.2013.7056
Invited Commentary | June 17, 2013 
Oxygen-Carrying Proteins in Meat and Risk of Diabetes Mellitus :  Comment on “Changes in Red Meat Consumption and Subsequent Risk of Type 2 Diabetes Mellitus: Three Cohorts of US Men and Women”
William J. Evans, PhD
The article by Pan et al1 confirms previous observations that the consumption of so-called red meat is associated with an increased risk ...
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JAMA Intern Med. Published online June 17, 2013. doi:10.1001/jamainternmed.2013.7399
Invited Commentary | June 17, 2013  FREE
Clostridium difficile Leaves the Hospital—What's Next?:  Comment on “Epidemiology of Community-Associated Clostridium difficile Infection, 2009 Through 2011”
Kent A. Sepkowitz, MD
Since their introduction after World War II, antibiotics have been known to cause gastrointestinal problems, including nausea and diarrhea. By the late ...
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JAMA Intern Med. Published online June 17, 2013. doi:10.1001/jamainternmed.2013.7940
Invited Commentary | June 17, 2013 
Overcoming the Human Immunodeficiency Virus Obstacle Course:  Comment on “Differences in Human Immunodeficiency Virus Care and Treatment Among Subpopulations in the United States”
Katerina A. Christopoulos, MD, MPH; Diane V. Havlir, MD
Approximately 50 000 new human immunodeficiency virus (HIV) infections develop in the United States each year.1 How many of these people know ...
JAMA Intern Med. Published online June 17, 2013. doi:10.1001/jamainternmed.2013.7943
Invited Commentary | June 17, 2013 
Promoting Delivery System Integration to Foster Higher Value Care: Slow Progress Ahead:  Comment on “Delivery System Integration and Health Care Spending and Quality for Medicare Beneficiaries”
Arnold M. Epstein, MD, MA
While most people think of the Affordable Care Act (ACA) as designed primarily to expand insurance coverage, the roughly 900-page bill establishes ...
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JAMA Intern Med. Published online June 17, 2013. doi:10.1001/jamainternmed.2013.7949
Original Investigation | June 10, 2013  FREE
Association Between Hypoglycemia and Dementia in a Biracial Cohort of Older Adults With Diabetes Mellitus
Kristine Yaffe, MD; Cherie M. Falvey, MPH; Nathan Hamilton, MA; Tamara B. Harris, MD; Eleanor M. Simonsick, PhD; Elsa S. Strotmeyer, PhD, MPH; Ronald I. Shorr, MD, MS; Andrea Metti, MPH; Ann V. Schwartz, PhD, MPH; for the Health ABC Study
ImportanceImportance Hypoglycemia commonly occurs in patients with diabetes mellitus (DM) and may negatively influence cognitive performance. Cognitive impairment in turn can compromise ...
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JAMA Intern Med. Published online June 10, 2013. doi:10.1001/jamainternmed.2013.6176
Invited Commentary | June 10, 2013  FREE
Glucose Control in Older Adults With Diabetes Mellitus—More Harm Than Good?:  Comment on “The Association Between Hypoglycemia and Dementia in a Biracial Cohort of Older Adults With Diabetes Mellitus”
Kasia J. Lipska, MD, MHS; Victor M. Montori, MD
Ms Andrews, your 83-year-old patient, is proud. She walks daily, watches her diet, and never misses her appointments. Her glycated hemoglobin (HbA1c) ...
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JAMA Intern Med. Published online June 10, 2013. doi:10.1001/jamainternmed.2013.6189
Original Investigation | June 10, 2013 
Extreme Bilirubin Levels as a Causal Risk Factor for Symptomatic Gallstone Disease
Stefan Stender, MD; Ruth Frikke-Schmidt, MD, DMSc; Børge G. Nordestgaard, MD, DMSc; Anne Tybjærg-Hansen, MD, DMSc
Includes: Supplemental Content
ImportanceImportance In individuals without blockage of their bile ducts, levels of plasma bilirubin likely reflect levels of biliary bilirubin; higher biliary bilirubin ...
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JAMA Intern Med. Published online June 10, 2013. doi:10.1001/jamainternmed.2013.6465
RESEARCH LETTER | June 10, 2013 
Use of Niacin in the United States and Canada
Cynthia A. Jackevicius, BScPhm, PharmD, MSc; Jack V. Tu, MD, PhD; Dennis T. Ko, MD, MSc; Noelle de Leon, PharmD; Harlan M. Krumholz, MD, SM
Includes: Supplemental Content
The failure of recent trials of extended-release niacin has focused attention on the use of niacin in practice.1- 2 Prior studies have ...
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JAMA Intern Med. Published online June 10, 2013. doi:10.1001/jamainternmed.2013.6489
Original Investigation | June 10, 2013 
Fat Intake After Diagnosis and Risk of Lethal Prostate Cancer and All-Cause Mortality
Erin L. Richman, ScD; Stacey A. Kenfield, ScD; Jorge E. Chavarro, MD, ScD; Meir J. Stampfer, MD, DrPH; Edward L. Giovannucci, MD, ScD; Walter C. Willett, MD, DrPH; June M. Chan, ScD
Includes: Supplemental Content
ImportanceImportance Nearly 2.5 million men currently live with prostate cancer in the United States, yet little is known about the association between ...
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JAMA Intern Med. Published online June 10, 2013. doi:10.1001/jamainternmed.2013.6536
Editor's Note | June 10, 2013 
Bilirubin, Gallstones, and Mendelian Randomization:  Comment on “Bilirubin Levels in Symptomatic Gallstone Disease”
Mitchell H. Katz, MD
Gallstone disease causes a substantial health and economic burden in the United States and other developed countries. More than 6 million men ...
JAMA Intern Med. Published online June 10, 2013. doi:10.1001/jamainternmed.2013.6568
RESEARCH LETTER | June 10, 2013 
Use of Acute Care Services Among Older Homeless Adults
Rebecca T. Brown, MD, MPH; Dan K. Kiely, MPH, MA; Monica Bharel, MD, MPH; Laura J. Grande, PhD; Susan L. Mitchell, MD, MPH
Includes: Supplemental Content
The median age of homeless single adults in the United States has increased from approximately 35 years in 1990 to nearly 50 ...
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JAMA Intern Med. Published online June 10, 2013. doi:10.1001/jamainternmed.2013.6627
Special Article | June 10, 2013 
“Less Is More” in Critically Ill Patients:  Not Too Intensive
Matthijs Kox, PhD; Peter Pickkers, MD, PhD
The current view in intensive care medicine is that very sick patients need very intensive treatment. However, in this group of highly ...
JAMA Intern Med. Published online June 10, 2013. doi:10.1001/jamainternmed.2013.6702

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