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 Showing 1-20 of 50 Articles

My father, an aeronautical engineer and one of the designers of the reentry heat shields for the Apollo spacecraft, was extremely methodical. Even when doing projects around the house, he would measure and remeasure before making a final cut.

Invited Commentary: A Maturing Use of Defibrillators; Joanne Lynn, MD
Original Investigation 
Michael Bretthauer, MD; Michal F. Kaminski, MD; Magnus Løberg, MD; Ann G. Zauber, PhD; Jaroslaw Regula, MD; Ernst J. Kuipers, MD; Miguel A. Hernán, MD; Eleanor McFadden, MA; Annike Sunde, MSc; Mette Kalager, MD; Evelien Dekker, MD; Iris Lansdorp-Vogelaar, PhD; Kjetil Garborg, MD; Maciej Rupinski, MD; Manon C. W. Spaander, MD; Marek Bugajski, MD; Ole Høie, MD; Tryggvi Stefansson, MD; Geir Hoff, MD; Hans-Olov Adami, MD; for the Nordic-European Initiative on Colorectal Cancer (NordICC) Study Group
Includes: Supplemental Content

Importance  Although some countries have implemented widespread colonoscopy screening, most European countries have not introduced it because of uncertainty regarding participation rates, procedure-related pain and discomfort, endoscopist performance, and effectiveness. To our knowledge, no randomized trials on colonoscopy screening currently exist.

Objective  To investigate participation rate, ...

Invited Commentary: Colorectal Cancer Screening With Colonoscopy; David Lieberman, MD
Original Investigation  FREE
Christina Abdel Shaheed, PhD; Chris G. Maher, PhD; Kylie A. Williams, PhD; Richard Day, MD; Andrew J. McLachlan, PhD
Includes: Supplemental Content

Importance  Opioid analgesics are commonly used for low back pain, however, to our knowledge there has been no systematic evaluation of the effect of opioid dose and use of enrichment study design on estimates of treatment effect.

Objective  To evaluate efficacy and tolerability of opioids in ...

Original Investigation 
Susan M. McCurry, PhD; Katherine A. Guthrie, PhD; Charles M. Morin, PhD; Nancy F. Woods, PhD, RN; Carol A. Landis, PhD, RN; Kristine E. Ensrud, MD, MPH; Joseph C. Larson, MS; Hadine Joffe, MD, MSc; Lee S. Cohen, MD; Julie R. Hunt, PhD; Katherine M. Newton, PhD; Julie L. Otte, PhD, RN; Susan D. Reed, MD, MPH; Barbara Sternfeld, PhD; Lesley F. Tinker, PhD; Andrea Z. LaCroix, PhD
Includes: Supplemental Content

Importance  Effective, practical, nonpharmacologic therapies are needed to treat menopause-related insomnia symptoms in primary and women’s specialty care settings.

Objective  To evaluate the efficacy of telephone-based cognitive behavioral therapy for insomnia (CBT-I) vs menopause education control (MEC).

Design, Setting, and Participants  A single-site, randomized clinical ...

Invited Commentary 
David Lieberman, MD

Colorectal cancer screening in individuals at average risk is effective, although the screening test considered the best remains uncertain. Randomized studies of fecal occult blood testing (conducted in the 1990s) and one-time screening sigmoidoscopy (conducted in the 2000s) demonstrated that patients who were screened had colorectal cancer detected ...

Invited Commentary 
Joanne Lynn, MD

When implantable cardioverter-defibrillators (ICDs) were first in broad use, about 20 years ago,1 they often seemed like a near-magical way to kick a troublesome heart back into doing its job. Without the serious risks and low yield of external cardiopulmonary resuscitation, a person could be resuscitated without ...

Challenges in Clinical Electrocardiography 
Jennifer M. Wright, MD; Michael E. Field, MD

A man in his 60s with prior heart transplantation presented with intermittent syncope. Cardiac ultrasonography and laboratory examination showed normal left ventricular function and clinical examination did not reveal any evidence of rejection. During an episode of lightheadedness, the following 12-lead electrocardiogram (ECG) was obtained (Figure 1...

Research Letter 
Robert Ferrari, MD, MSc (Med), FRCPC; Connie Prosser, PhD, FCACB

This article describes a criteria-based approach to testing vitamin D levels.

Research Letter 
James N. Kirkpatrick, MD; Paul J. Hauptman, MD; Keith M. Swetz, MD; Elizabeth D. Blume, MD; Kimberlee Gauvreau, ScD; Mathew Maurer, MD; Sarah J. Goodlin, MD

This survey study assesses attitudes among clinicians toward palliative care in patients receiving transcatheter aortic valve replacement and ventricular assist devices.

Carolyn L. Treasure, MD; Aaron S. Kesselheim, MD, JD, MPH

The Viewpoint discusses the effects of “patent trolls” on generic drug prices and availability.

Original Investigation 
Steven C. Moore, PhD, MPH; I-Min Lee, MBBS, ScD; Elisabete Weiderpass, PhD; Peter T. Campbell, PhD; Joshua N. Sampson, PhD; Cari M. Kitahara, PhD; Sarah K. Keadle, PhD, MPH; Hannah Arem, PhD; Amy Berrington de Gonzalez, DPhil; Patricia Hartge, ScD; Hans-Olov Adami, MD, PhD; Cindy K. Blair, PhD; Kristin B. Borch, PhD; Eric Boyd, BS; David P. Check, BS; Agnès Fournier, PhD; Neal D. Freedman, PhD; Marc Gunter, PhD; Mattias Johannson, PhD; Kay-Tee Khaw, MD, MsC, PhD; Martha S. Linet, MD; Nicola Orsini, PhD; Yikyung Park, ScD; Elio Riboli, MD; Kim Robien, PhD; Catherine Schairer, PhD; Howard Sesso, ScD, MPH; Michael Spriggs, BS; Roy Van Dusen, MS; Alicja Wolk, DMSc; Charles E. Matthews, PhD; Alpa V. Patel, PhD
Includes: Supplemental Content

Importance  Leisure-time physical activity has been associated with lower risk of heart-disease and all-cause mortality, but its association with risk of cancer is not well understood.

Objective  To determine the association of leisure-time physical activity with incidence of common types of cancer and whether associations vary ...

Invited Commentary: Leisure-Time Physical Activity to Reduce Risk of Cancer Development; Lauren E. McCullough, PhD; Kathleen M. McClain, MS; Marilie D. Gammon, PhD
Original Investigation 
Shanshan Li, ScD; Meir J. Stampfer, MD, DrPH; David R. Williams, PhD; Tyler J. VanderWeele, PhD
Includes: Supplemental Content

Importance  Studies on the association between attendance at religious services and mortality often have been limited by inadequate methods for reverse causation, inability to assess effects over time, and limited information on mediators and cause-specific mortality.

Objective  To evaluate associations between attendance at religious services and ...

Invited Commentary: Empirical Studies About Religious Service Attendance and Health; Dan German Blazer II, MD, MPH, PhD
Invited Commentary 
Lauren E. McCullough, PhD; Kathleen M. McClain, MS; Marilie D. Gammon, PhD

Cancer is among the leading causes of morbidity and mortality worldwide, with 14.1 million new cancer cases and 8.2 million cancer-related deaths in 2012.1(p3) By 2030 the global cancer burden is expected to double, with 21.7 million new cases and 13.2 million cancer deaths projected due ...

Invited Commentary 
Dan German Blazer II, MD, MPH, PhD

In this issue of JAMA Internal Medicine, Li et al1 report a clear and moderately strong association between attendance at religious services and decreased mortality during a 16-year follow-up of a subgroup from the Nurses’ Health Study. The study by Li et al1 includes baseline ...

Invited Commentary 
Samantha Artiga, MHSA; Barbara Lyons, PhD

In this issue of JAMA Internal Medicine, Frean and colleagues1 find Medicaid coverage gains among American Indians and Alaska Natives (AIANs) in states that expanded Medicaid under the Affordable Care Act (ACA) Medicaid expansion. They also find that, among AIANs living near reservations, most gaining Medicaid utilize ...

Special Communication 
Lara Goitein, MD; Brent James, MD, MStat

Standardization of medical care through protocols, order sets, and other tools is increasingly a part of efforts to improve quality. The authors, a physician beginning a new position as director of a community hospital quality program and the chief quality officer of a health care system and director ...

Research Letter 
Molly Frean, BA; Shelbie Shelder; Meredith B. Rosenthal, PhD; Thomas D. Sequist, MD, MPH; Benjamin D. Sommers, MD, PhD

This study evaluates changes in insurance and Indian Health Service coverage among Native Americans following the Affordable Care Act’s implementation.

Invited Commentary: Medicaid Coverage, the ACA, and American Indians and Alaska Natives; Samantha Artiga, MHSA; Barbara Lyons, PhD
Teachable Moment 
Faizan Khan, BSc; Marc Carrier, MD, MSc; Marc Rodger, MD, MSc

This Teachable Moment discusses how aggressive physicians should be in screening for an occult cancer in patients with unprovoked venous thromboembolism.

Joshua M. Sharfstein, MD; Jeremy Greene, MD, PhD

Generic drugs now make up more than 88% of all prescriptions filled in pharmacies in the United States and have provided nearly $1.7 trillion in health care savings in the past decade.1 Yet tensions still persist between brand-name drugs and generics. Fifty years ago, pharmaceutical companies hurled ...

Original Investigation 
Justin Knox, MPH; Sean B. Sullivan, MPH; Julia Urena, BA; Maureen Miller, PhD; Peter Vavagiakis, MS; Qiuhu Shi, PhD; Anne-Catrin Uhlemann, MD, PhD; Franklin D. Lowy, MD

Importance  The role of environmental contamination in recurrent Staphylococcus aureus infections within households and its potential effect on intervention strategies has been debated recently.

Objective  To assess whether household environmental contamination increases the risk for recurrent infection among individuals with a community-associated methicillin-resistant S aureus (MRSA) ...

Editor's Note: Cleaning House; Mitchell H. Katz, MD

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