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Basic View | Expanded View
 Showing 1-20 of 62 Articles
Viewpoint  FREE
Lisa Aliferis, BA
This Viewpoint reports crowdsourced health care prices in California.
Perspective 
Charlie Wray, DO
Original Investigation 
R. Scott Miller, MD; Lindell K. Weaver, MD; Nazanin Bahraini, PhD; Susan Churchill, APRN-NP; Robert C. Price, MD; Virginia Skiba, MD; James Caviness, MD; Scott Mooney, PhD; Brian Hetzell, MS; Jun Liu, PhD; Kayla Deru, BA; Richard Ricciardi, PhD; Susan Fracisco, MD; Nicole C. Close, PhD; Gerald W. Surrett, MD; Corinna Bartos, MD; Margaret Ryan, MD; Lisa A. Brenner, PhD; for the HOPPS Trial Team
Includes: Supplemental Content

Importance  Improvement has been anecdotally observed in patients with persistent postconcussion symptoms (PCS) after mild traumatic brain injury following treatment with hyperbaric oxygen (HBO). The effectiveness of HBO as an adjunctive treatment for PCS is unknown to date.

Objectives  To compare the safety of and to ...

Original Investigation 
Anil N. Makam, MD, MAS; Oanh K. Nguyen, MD, MAS

Importance  Cardiac biomarker testing is not routinely indicated in the emergency department (ED) because of low utility and potential downstream harms from false-positive results. However, current rates of testing are unknown.

Objective  To determine the use of cardiac biomarker testing overall, as well as stratified by ...

Original Investigation 
Meera Viswanathan, PhD; Leila C. Kahwati, MD, MPH; Carol E. Golin, MD; Susan J. Blalock, MPH, PhD; Emmanuel Coker-Schwimmer, MPH; Rachael Posey, MSLS; Kathleen N. Lohr, PhD, MPhil, MA
Includes: Supplemental Content

Importance  Medication therapy management (MTM) services (also called clinical pharmacy services) aim to reduce medication-related problems and their downstream outcomes.

Objective  To assess the effect of MTM interventions among outpatients with chronic illnesses.

Data Sources  MEDLINE, Cochrane Library, and International Pharmaceutical Abstracts through January ...

Invited Commentary 
Charles W. Hoge, MD; Wayne B. Jonas, MD
During the past decade, unprecedented clinical and research resources have been directed toward addressing 2 conditions considered “silent” and “signature injuries” of the Iraq and Afghanistan wars, namely, posttraumatic stress disorder (PTSD) and concussion (mild traumatic brain injury). This investment is increasingly paying dividends in knowledge and interventions that are ...
Editor's Note 
Rita F. Redberg, MD, MSc
The assumption that market principles apply to the choices consumers (that is, patients) make about their medical care is an important part of health care policy and regulations in the United States. This assumption, however, belies the facts that health care is mostly not paid for out of pocket, that ...
Research Letter 
Michael D. Miedema, MD, MPH; Faye L. Lopez, MS, MPH; Michael J. Blaha, MD, MPH; Salim S. Virani, MD, PhD; Josef Coresh, MD, PhD; Christie M. Ballantyne, MD; Aaron R. Folsom, MD, MPH
The 2013 guidelines of the American College of Cardiology and American Heart Association (ACC/AHA) for treatment of cholesterol levels recommend statin therapy for individuals at an elevated absolute risk for cardiovascular disease (CVD).1 This risk-based approach is a paradigm shift from prior Adult Treatment Panel (ATP) III guidelines2 that were ...
This Viewpoint describe the case of the commercial withdrawal of tositumomab as a cautionary tale of the weaknesses in our current drug-approval system.
Perspective 
Chelsea Bowman, MD; Eric Widera, MD
Original Investigation 
Walid F. Gellad, MD, MPH; Xinhua Zhao, PhD; Carolyn T. Thorpe, PhD, MPH; Maria K. Mor, PhD; Chester B. Good, MD, MPH; Michael J. Fine, MD, MSc

Importance  Self-monitoring of blood glucose is a costly component of care for diabetes mellitus, with unclear benefits for patients not taking insulin. Veterans with dual Department of Veterans Affairs (VA) and Medicare benefits have access to test strips through both systems, raising the potential for overuse.

Objectives...

Original Investigation 
Martha L. Bruce, PhD, MPH; Patrick J. Raue, PhD; Catherine F. Reilly, MPH; Rebecca L. Greenberg, MS; Barnett S. Meyers, MD; Samprit Banerjee, PhD; Yolonda R. Pickett, MD, MS; Thomas F. Sheeran, PhD, ME; Angela Ghesquiere, PhD; Diane M. Zukowski, RN, BSN; Vianca H. Rosas, MPH; Jeanne McLaughlin, MSN, MSEd; Lori Pledger, RN-BC; Joan Doyle, RN, MSN, MBA; Pamela Joachim, RN, MA; Andrew C. Leon, PhD
Includes: Supplemental Content

Importance  Among older home health care patients, depression is highly prevalent, is often inadequately treated, and contributes to hospitalization and other poor outcomes. Feasible and effective interventions are needed to reduce this burden of depression.

Objective  To determine whether, among older Medicare Home Health recipients who ...

Invited Commentary 
Constantine G. Lyketsos, MD, MHS
The rapid aging of the population is accompanied by commensurate growth in the number of individuals who have complex chronic medical conditions (diabetes mellitus, heart disease, lung disease, etc). These people are increasingly less able to interact with health care services outside of their homes. At the same time, those ...
Invited Commentary 
R. William Vandivier, MD
Secondhand tobacco smoke (SHS) consists of a combination of mainstream smoke that is exhaled from a smoker and sidestream smoke that is given off by a burning cigarette. There is no known safe level of SHS exposure, and it is associated with multiple health risks including sinorespiratory disease, cancer, and ...
Special Communication 
Sanjay Sharma, MD, FRCP(UK), FESC; Ahmed Merghani, MRCP(UK); Sabiha Gati, BSc(Hons), MRCP(UK)

Deaths of young athletes from cardiac disease are uncommon but receive considerable media attention and intermittently galvanize debates about cardiac screening prior to participation in sports. Both the American Heart Association (AHA) and European Society of Cardiology (ESC) endorse preparticipation screening in athletes; however, there is disagreement about ...

Research Letter 
Sandra J. Japuntich, PhD; Michelle A. Eilers, BA; Sharon Shenhav, BA; Elyse R. Park, PhD, MPH; Jonathan P. Winickoff, MD; Neal L. Benowitz, MD; Nancy A. Rigotti, MD
Exposure to secondhand tobacco smoke (SHS) increases adult nonsmokers’ risk of cardiovascular disease by 25% to 30%.1 Among nonsmokers hospitalized with acute coronary syndrome, SHS exposure is associated with a higher likelihood of subsequent cardiovascular and all-cause mortality as well as reinfarction.2,3 Hospitalized nonsmokers with coronary heart disease (CHD) should ...
Viewpoint 
Mori J. Krantz, MD; Sanjay Kaul, MD
This Viewpoint questions the benefit-risk balance of vorapaxar use as a component of 3-drug antiplatelet therapy for cardiovascular disease.
Perspective 
Dan Merenstein, MD
I must have won. That is what everyone tells me. At the beginning there were a few telephone calls, followed by e-mails, and now every talk I give someone brings up how happy I must feel for winning. What I purportedly won was the new recommendations against routine checking for ...
Original Investigation 
Inmaculada Hernandez, PharmD; Seo Hyon Baik, PhD; Antonio Piñera, MD; Yuting Zhang, PhD
Includes: Supplemental Content

Importance  It remains unclear whether dabigatran etexilate mesylate is associated with higher risk of bleeding than warfarin sodium in real-world clinical practice.

Objective  To compare the risk of bleeding associated with dabigatran and warfarin using Medicare data.

Design, Setting, and Participants  In this retrospective cohort ...

Original Investigation 
David A. Cook, MD, MHPE; Eric S. Holmboe, MD; Kristi J. Sorensen, MSEd; Richard A. Berger, MD, PhD; John M. Wilkinson, MD
Includes: Supplemental Content

Importance  Despite general support for the goals of maintenance of certification (MOC), concerns have been raised about its effectiveness, relevance, and value.

Objective  To identify barriers and enabling features associated with MOC and how MOC can be changed to better accomplish its intended purposes.

Design, Setting, ...

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