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 Showing 1-20 of 76 Articles
Viewpoint 
Robert C. McMillen, PhD; Mark A. Gottlieb, JD; Jonathan P. Winickoff, MD, MPH

This Viewpoint emphasizes the need for final FDA regulations for e-cigarettes to address product design, flavors, and marketing that appeal to younger individuals.

Teachable Moment 
Abhinav Sharma, MD; James S. Khan, MD, MSc; Kevin R. Bainey, MD, MSc

This Teachable Moment emphasizes that preoperative investigations must be used judiciously to avoid treatment delay and that complete history, clinical risk stratification, and careful patient selection can identify most patients at high risk who may benefit from further investigations.

Original Investigation 
John Weiser, MD, MPH; Linda Beer, PhD; Emma L. Frazier, PhD; Roshni Patel, MPH; Antigone Dempsey, MEd; Heather Hauck, MSW; Jacek Skarbinski, MD
Includes: Supplemental Content

Importance  Outpatient human immunodeficiency virus (HIV) health care facilities receive funding from the Ryan White HIV/AIDS Program (RWHAP) to provide medical care and essential support services that help patients remain in care and adhere to treatment. Increased access to Medicaid and private insurance for HIV-infected persons may ...

Invited Commentary: The Future of the Ryan White HIV/AIDS Program; Stephen F. Morin, PhD
Original Investigation 
Natalie C. Ernecoff, MPH; Farr A. Curlin, MD; Praewpannarai Buddadhumaruk, RN, MS; Douglas B. White, MD, MAS
Includes: Supplemental Content

Importance  Although many patients and their families view religion or spirituality as an important consideration near the end of life, little is known about the extent to which religious or spiritual considerations arise during goals-of-care conversations in the intensive care unit.

Objectives  To determine how frequently ...

Invited Commentary: Religion, Spirituality and the Intensive Care Unit; Tracy A. Balboni, MD, MPH; Michael J. Balboni, PhD, MDiv; George Fitchett, DMin, PhD
Original Investigation 
Sara Kalkhoran, MD; Stanton A. Glantz, PhD
Includes: Supplemental Content

Importance  The prevalence of electronic cigarette (e-cigarette) use is increasing. Population health effects will depend on cigarette smoking behaviors, levels of dual use with conventional cigarettes, and e-cigarette toxicity.

Objective  To evaluate potential health effects of various scenarios of increasing promotion and use of e-cigarettes.

Design, ...

Invited Commentary 
Tracy A. Balboni, MD, MPH; Michael J. Balboni, PhD, MDiv; George Fitchett, DMin, PhD

Visualize for a moment the philosophical quandary of a tree falling in the uninhabited forest and whether it makes a sound—the dying tree, its surroundings of fellow trees, foliage, and earth—with no person to hear its fall. This visualization hardly seems relevant to the intensive care unit (ICU), ...

Invited Commentary 
Stephen F. Morin, PhD

The Ryan White HIV/AIDS Program provides medical care and support services to more than half a million poor and underinsured people living with human immunodeficiency virus in the United States.1 Now 25 years old, this congressionally appropriated program has been at the center of the US response ...

Research Letter 
Akshay Sood, MD; Newaj M. Abdullah, MD; Firas Abdollah, MD; Marwan S. Abouljoud, MD; Quoc-Dien Trinh, MD; Mani Menon, MD; Jesse D. Sammon, DO

This database review found that by 2010 the incidence of kidney transplantation for black and white patients with end-stage renal disease was equivalent, but kidney transplants from living donors were 43.2% for whites and only 22.2% for blacks.

Perspective 
Meghan O’Brien, MD, MBE

One predawn morning during my medical school surgery rotation, I noticed threatening shadows in my groin—lymph nodes decorating my normally smooth inguinal creases. I had lost a little weight too, despite deliberate attempts to bulk up, symptoms that stuck in the refining sieve of my developing medical intuition. ...

Original Investigation 
Justine E. F. Moonen, MD; Jessica C. Foster-Dingley, MSc; Wouter de Ruijter, MD, PhD; Jeroen van der Grond, PhD; Anne Suzanne Bertens, MD; Mark A. van Buchem, MD, PhD; Jacobijn Gussekloo, MD, PhD; Huub A. Middelkoop, PhD; Marieke J. H. Wermer, MD, PhD; Rudi G. J. Westendorp, MD, PhD; Anton J. M. de Craen, PhD; Roos C. van der Mast, MD, PhD
Includes: Supplemental Content

Importance  Observational studies indicate that lower blood pressure (BP) increases risk for cognitive decline in elderly individuals. Older persons are at risk for impaired cerebral autoregulation; lowering their BP may compromise cerebral blood flow and cognitive function.

Objective  To assess whether discontinuation of antihypertensive treatment in ...

Invited Commentary: Discontinuation Trial of Antihypertensive Treatment; Michelle C. Odden, PhD
Original Investigation 
Jing Luo, MD; Jerry Avorn, MD; Aaron S. Kesselheim, MD, JD, MPH

Importance  Insulin is a vital medicine for patients with diabetes mellitus. Newer, more expensive insulin products and the lack of generic insulins in the United States have increased costs for patients and insurers.

Objective  To examine Medicaid payment trends for insulin products. Cost information is available ...

Invited Commentary 
Michelle C. Odden, PhD

The overwhelming majority of research and guidelines has focused on the initiation and intensification of medication therapy. Not surprisingly, the burden of medication use in older adults is high; nearly 40% of adults 65 years or older and 50% of those 80 years or older are using 5 ...

Invited Commentary 
Laura E. Riley, MD

In their study of the diversity of graduate medical education in the United States, Deville and colleagues1 call attention yet again to the continued underrepresentation of women and minority groups in medicine compared with the population as a whole. Among the many interesting findings, I was most ...

Research Letter 
Michael E. Johansen, MD, MS; Lee A. Green, MD, MPH

This survey investigates the use of statins in individuals older than 79 years by vascular disease.

Research Letter 
Curtiland Deville, MD; Wei-Ting Hwang, PhD; Ramon Burgos, AB; Christina H. Chapman, MD; Stefan Both, PhD; Charles R. Thomas Jr, MD

In this data analysis, graduate medical education diversity was assessed by race, ethnicity, and sex in 2012.

Invited Commentary: Ensuring a Diverse Physician Workforce; Laura E. Riley, MD
Perspective 
Jennifer DeVoe, MD, DPhil

I recently went home to spend spring break with my 73-year-old father, who lived alone with emphysema. I had planned to discuss a move to assisted living; I had no intimation that this would, instead, be his last week of life. When I arrived, he could barely breathe. ...

Original Investigation 
Lainie Rutkow, JD, PhD, MPH; Hsien-Yen Chang, PhD; Matthew Daubresse, MHS; Daniel W. Webster, ScD, MPH; Elizabeth A. Stuart, PhD; G. Caleb Alexander, MD, MS
Includes: Supplemental Content

Importance  Prescription Drug Monitoring Program (PDMP) and pill mill laws are among the principal means states use to reduce prescription drug abuse and diversion, yet little high-quality evidence exists regarding their effect.

Objective  To quantify the effect of Florida’s PDMP and pill mill laws on overall ...

This commentary on a recently published article from the JAMA Network places in context findings on risks of malfunction in cardiovascular implantable electronic devices during radiation therapy for cancer.

Challenges in Clinical Electrocardiography 
Ali Pourdjabbar, MD; Martin S. Green, MD; Pablo B. Nery, MD

The 12-lead electrocardiogram (ECG) is a diagnostic tool in cardiology and similar to other diagnostic tests is also susceptible to misinterpretation. Understanding the principles of ECG acquisition is essential to accurate interpretation. The reported cases highlight the importance of applying these principles to challenging scenarios in which the ...

Research Letter 
Rabeea F. Khan, MD; Shelli Feder, MSN; Nathan E. Goldstein, MD; Sarwat I. Chaudhry, MD

This study evaluated the spectrum of symptoms, improvement in symptoms after discharge, and perceptions of palliative care among patients who were hospitalized for heart failure.

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