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The Cost of Defensive Medicine on 3 Hospital Medicine Services. Rothberg et al.

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US Cigarette Smoking–Attributable Morbidity

This modeling study estimates that US adults have approximately 14 million major medical conditions attributable to smoking.
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Evidence Supporting Pharmacogenomic Biomarker Testing

This review of US FDA databases reports that very few drug labels that recommend use of pharmacogenomic biomarkers reference convincing evidence of the markers’ clinical utility.
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Lung Cancer Screening

These perspectives address the use of low dose CT scan for lung cancer screening.
Lung Cancer Screening for Medicare Patients
Evidence for CT Screening for Lung Cancer?
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Public Health in the Age of Ebola in West Africa

Osterholm et al. discuss the Ebola epidemic in West Africa and the impact from this "Black Swan" event.

β-Lactam Treatment for Pneumonia

This open-label noninferiority trial of β-lactam monotherapy vs combination β-lactam-macrolide treatment for moderately severe community-acquired pneumonia demonstrated worse outcomes with monotherapy for patients with atypical pathogens or severe infection.
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Interview with Brian L. Rostron, PhD, MPH, author of Estimation of Cigarette Smoking–Attributable Morbidity in the United States, and Steven A. Schroeder, MD, author of Even More Illness Caused by Smoking Than Previously Estimated


Estimation of Cigarette Smoking–Attributable Morbidity in the United States

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Challenges in Clinical Electrocardiography

Case studies of patients with challenging electrocardiograms.

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Articles about how overuse of medical care may result in harm and how less intervention may lead to better health.

Teachable Moments

JAMA Internal Medicine is pleased to launch a new subsection of Perspectives, Teachable Moments, to bring attention to the harms that can result from medical overuse and from underuse of needed medical interventions. The format for submitting an entry is described here; manuscripts should be submitted here as usual. Note we need written permission from patients to include their story.

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Author Mara A. Schonberg, MD, MPH, discusses Development and Evaluation of a Decision Aid on Mammography Screening for Women 75 Years and Older.

Author Russell P. Harris, MD, MPH, discusses The Harms of Screening: A Proposed Taxonomy and Application to Lung Cancer Screening.

Author Karen J. Wernli, PhD, discusses Patterns of Breast Magnetic Resonance Imaging Use in Community Practice.

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