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The Cost of Defensive Medicine on 3 Hospital Medicine Services. Rothberg et al.

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Use of Medications of Questionable Benefit in Advanced Dementia. Tjia et al.

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Glucose-Lowering Medication for Diabetes

This cohort study found that compared to other oral antidiabetic agents, initial treatment with metformin was associated with reduced subsequent treatment intensification without differences in rates of adverse clinical events among privately insured patients with diabetes.
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Opioid Agonist Therapy and HCV Infection

This observational cohort study reports that maintenance treatment with methadone or buprenorphine for opioid use disorders was associated with a lower incidence of hepatitis C virus infection among young injection drug users.

Outcomes Associated With Invasive and Noninvasive Ventilation

In this cohort study, patients with COPD treated with noninvasive ventilation at the time of hospitalization had lower inpatient mortality, shorter length of stay, and lower costs compared with those treated with invasive mechanical ventilation.

Buprenorphine for Prescription Opioid Dependence

This randomized clinical trial reports that buprenorphine taper is less efficacious than ongoing maintenance treatment in patients dependent on prescription opioids in primary care.

Impulse Control Disorders and Dopamine Agonists

This review of FDA adverse event reports describes an association between dopamine receptor agonists and pathological gambling, hypersexuality, and compulsive shopping.
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Invited Commentary:Dopamine Receptor Agonist Drugs and Impulse Control Disorders

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Interview with Brian L. Rostron, PhD, MPH, author of Estimation of Cigarette Smoking–Attributable Morbidity in the United States, and Steven A. Schroeder, MD, author of Even More Illness Caused by Smoking Than Previously Estimated

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Estimation of Cigarette Smoking–Attributable Morbidity in the United States

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Case studies of patients with challenging electrocardiograms.

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Teachable Moments

JAMA Internal Medicine is pleased to launch a new subsection of Perspectives, Teachable Moments, to bring attention to the harms that can result from medical overuse and from underuse of needed medical interventions. The format for submitting an entry is described here; manuscripts should be submitted here as usual. Note we need written permission from patients to include their story.

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Author Mara A. Schonberg, MD, MPH, discusses Development and Evaluation of a Decision Aid on Mammography Screening for Women 75 Years and Older.

Author Russell P. Harris, MD, MPH, discusses The Harms of Screening: A Proposed Taxonomy and Application to Lung Cancer Screening.

Author Karen J. Wernli, PhD, discusses Patterns of Breast Magnetic Resonance Imaging Use in Community Practice.

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