TY  - JOUR
T1  - THe relation between p70s6k expression in lymphocytes and the decline of cognitive test scores in patients with alzheimer disease
AU  - Paccalin M, Pain-Barc S, Pluchon C, et al
Y1  - 2005/11/14
N1  - 10.1001/archinte.165.20.2428
JO  - Archives of Internal Medicine
SP  - 2428
EP  - 2429
VL  - 165
IS  - 20
N2  - 
Memory disturbances are one of the first clinical signs detected in patients with Alzheimer disease (AD). The control of protein translation, including the kinases mTOR (mammalian target of rapamycin) and p70S6k, participates in explicit memory formation. Peripheral lymphocytes have impaired metabolism in AD.1 Our group recently reported a significant decrease of activated p70S6k expression in lymphocytes of patients with AD compared with control individuals.2 We report herein a significant correlation between activated p70S6k expression and long-term and working memory and language alterations.

SN  - 0003-9926
M3  - doi: 10.1001/archinte.165.20.2428
UR  - http://dx.doi.org/10.1001/archinte.165.20.2428
ER  -