TY  - JOUR
T1  - PRolonged qt interval and ventricular fibrillation after treatment with sublingual nifedipine for malignant hypertension
AU  - Peters FJ, Zwaan C, Kho L
Y1  - 1997/12/08
N1  - 10.1001/archinte.1997.00440430147025
JO  - Archives of Internal Medicine
SP  - 2665
EP  - 2666
VL  - 157
IS  - 22
N2  - Nifedipine is widely used in the treatment of hypertension and angina pectoris.1,2 Multiple adverse effects have been described, such as head-ache, peripheral edema, flushing, dizziness, and myocardial ischemia.3 Some adverse effects are induced by an abrupt decrease in arterial pressure.We describe a patient with malignant hypertension who developed ventricular fibrillation after treatment with sublingual short-acting nifedipine. To our knowledge, this adverse effect of nifedipine has not been published previously.A 34-year-old woman was admitted with a 4-week history of occipital headache, nose bleeding, vomiting, and visual disturbances, without angina pectoris. She had a history of atrioventricular nodal re-entry tachycardia but not hypertension. She used levonorgestrel ethinyl estradiol, 30 μg/d, and acetaminophen, 500 mg, 4 times a day. On examination, her blood pressure was 200/140 mm Hg in both arms and her pulse rate was regular at 85 bpm. The results of further physical examination and laboratory investigations
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1997.00440430147025
UR  - http://dx.doi.org/10.1001/archinte.1997.00440430147025
ER  -