TY  - JOUR
T1  - COma from long-term overingestion of isoniazid
AU  - Salkind AR, Hewitt CC
Y1  - 1997/11/24
N1  - 10.1001/archinte.1997.00440420156017
JO  - Archives of Internal Medicine
SP  - 2518
EP  - 2520
VL  - 157
IS  - 21
N2  - Overingestion of isoniazid can cause confusion, slurred speech, seizures, coma, and death. Most cases of a central nervous system toxic reaction due to isoniazid use result from sudden intentional or accidental overdose. We describe a patient taking 1200 mg of isoniazid daily for 6 weeks who presented to the hospital with confusion and lethargy that progressed to coma. Within 30 minutes of receiving 1 g of intravenous pyridoxine hydrochloride, the patient was fully alert and lucid. The diagnosis of a toxic reaction to isoniazid was delayed by the possibility of concurrent active neurosyphilis and the failure to initially consider isoniazid poisoning in a patient without a history of sudden isoniazid overdose.Arch Intern Med. 1997;157:2518-2520
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1997.00440420156017
UR  - http://dx.doi.org/10.1001/archinte.1997.00440420156017
ER  -