TY  - JOUR
T1  - UPdate on rifampin drug interactions, iii
AU  - Strayhorn VA, Baciewicz AM, Self TH
Y1  - 1997/11/24
N1  - 10.1001/archinte.1997.00440420085007
JO  - Archives of Internal Medicine
SP  - 2453
EP  - 2458
VL  - 157
IS  - 21
N2  - Rifampin is a potent inducer of cytochrome P-450 oxidative enzymes. Examples of well-documented, clinically significant interactions include warfarin, oral contraceptives, cyclosporine, glucocorticoids, ketoconazole, theophylline, quinidine, digitoxin, and verapamil. Recent reports have demonstrated clinically relevant interactions with protease inhibitors, zidovudine, delavirdine, itraconazole, nifedipine, midazolam or triazolam, nortriptyline, and doxycycline. To avoid reduced therapeutic response, therapeutic failure, or toxic reactions when rifampin is added to or discontinued from medication regimens, clinicians need to be cognizant of these interactions. Enhanced knowledge of known interactions will continue to develop, including research on induction of specific cytochrome P-450 isoenzymes. New rifampin interactions will be discovered with further investigations.Arch Intern Med. 1997;157:2453-2458
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1997.00440420085007
UR  - http://dx.doi.org/10.1001/archinte.1997.00440420085007
ER  -