TY  - JOUR
T1  - CHanges in lp(a) lipoprotein and lipid levels after cessation of female sex hormone production and estrogen replacement therapy
AU  - Kim C, Ryu W, Kwak J, Park C, Ryoo U
Y1  - 1996/03/11
N1  - 10.1001/archinte.1996.00440050046005
JO  - Archives of Internal Medicine
SP  - 500
EP  - 504
VL  - 156
IS  - 5
N2  - Objective: 
    To investigate the serial changes in Lp(a) lipoprotein levels with the loss of female sex hormones by surgical menopause and with estrogen replacement therapy in the same women.Patients and Methods: 
    Forty-four premenopausal women who underwent a transabdominal hysterectomy (TAH) because of benign gynecological disorders were divided into two groups: women who underwent a TAH and unilateral salpingo-oophorectomy (n=31) and women who underwent a TAH and bilateral salpingo-oophorectomy (n=13). In the group of women who underwent a TAH and bilateral salpingo-oophorectomy, 0.625 mg of conjugated equine estrogen was given daily 2 months after the operation. The levels of Lp(a) lipoprotein and lipids were measured before and at 2 and 4 months after the operation.Results: 
    In the group of women who underwent a TAH and bilateral salpingo-oophorectomy, the mean (±SD) concentration of Lp(a) lipoprotein was increased by 24.5% from 0.48±0.47 mmol/L (18.4± 18.3 mg/dL) to 0.59±0.54 mmol/L (22.9±21.0 mg/dL) after 2 months (P<.05), and it was reduced by 30.6% to 0.41±0.51 mmol/L (15.9±20.1 mg/dL) (P<.005) with therapy with conjugated equine estrogen (Premarin). The Lp(a) lipoprotein levels were not changed in the group of women who underwent a TAH and unilateral salpingooophorectomy. In the group of women who underwent a TAH and bilateral salpingo-oophorectomy, the high-density lipoprotein cholesterol level showed a trend of increase after 2 months from 1.45±0.48 mmol/L (56.1 ±18.5 mg/dL) to 1.58±0.39 mmol/L (61.2±15.1 mg/dL) without statistical significance, and it revealed a significant elevation to 1.76±0.43 mmol/L (68.2± 16.8 mg/dL) with therapy with conjugated equine estrogen (Premarin) compared with that of the basal level (P<.05).Conclusions: 
    The Lp(a) lipoprotein levels appear to be closely associated with female sex hormones. This association might play a pivotal role in postmenopausal increases of atherosclerotic diseases and cardioprotective effect of estrogen in postmenopausal women.(Arch Intern Med. 1996;156:500-504)
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1996.00440050046005
UR  - http://dx.doi.org/10.1001/archinte.1996.00440050046005
ER  -