TY  - JOUR
T1  - KAposi's sarcoma-associated herpesvirus and kaposi's sarcoma in africa
AU  - Chang Y, Ziegler J, Wabinga H, et al
Y1  - 1996/01/22
N1  - 10.1001/archinte.1996.00440020112014
JO  - Archives of Internal Medicine
SP  - 202
EP  - 204
VL  - 156
IS  - 2
N2  - Background: 
    Endemic Kaposi's sarcoma (KS) is a clinically and epidemiologically distinct human immunodeficiency virus negative form of KS occurring in Africa. Kaposi's sarcoma is now the most frequently reported cancer in some areas of Africa.Objective: 
    To determine if a KS-associated herpes-virus (KSHV) is present in both endemic HIV-seronegative and HIV-seropositive KS lesions from African patients.Methods: 
    Paraffin-embedded tissue specimens from Ugandan patients with KS and non-KS tumor control patients attending a university-based oncology clinic were examined in a blinded case-control study. Tissue DNA specimens were examined for detectable KSHV genome by nested polymerase chain reaction performed at two independent laboratories.Results: 
    We identified KSHV in 17 (85%) of 20 KS tissue specimens from HIV-seronegative patients and 22 (92%) of 24 KS tissue specimens from HIV-infected persons. Kaposi's sarcoma lesions from four HIV-infected persons and four HIV-seronegative persons were positive for KSHV. Unlike previous studies in North America and Europe, three (14%) of 22 non-KS cancer control patients' tissue specimens were also positive for KSHV that resulted in an overall odds ratio of 49.2 (95% confidence interval, 9.1 to 335) for detecting KSHV in KS lesions from patients in Uganda.Conclusion: 
    As in North America and Europe, KSHV infection is strongly associated with both HIV-seropositive and HIV-seronegative KS in Africa. However, it is likely that infection with this virus is more highly prevalent in Uganda.(Arch Intern Med. 1996;156:202-204)
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1996.00440020112014
UR  - http://dx.doi.org/10.1001/archinte.1996.00440020112014
ER  -