TY  - JOUR
T1  - POtassium restoration in hypertensive patients made hypokalemic by hydrochlorothiazide
AU  - Schnaper HW, Freis ED, Friedman RG, et al
Y1  - 1989/12/01
N1  - 10.1001/archinte.1989.00390120043009
JO  - Archives of Internal Medicine
SP  - 2677
EP  - 2681
VL  - 149
IS  - 12
N2  - • Among 447 hypertensive patients, most with a history of diuretic-induced hypokalemia, 252 developed diuretic-induced hypokalemia while receiving hydrochlorothiazide, 50 mg/d. In a randomized study we evaluated the efficacy of three drug regimens in restoring potassium levels while maintaining blood pressure control: hydrochlorothiazide (50 mg/d) plus potassium supplement (20 mmol/d); hydrochlorothiazide (50 mg/d) plus potassium supplement (40 mmol/d); or hydrochlorothiazide (50 mg/d) with triamterene (75 mg/d) in one combination tablet. In all groups, mean serum levels of potassium rose within 1 week and showed no further change thereafter. However, the hydrochlorothiazide/triamterene and hydrochlorothiazide plus 40 mmol of potassium regimens were significantly more effective in restoring serum potassium levels than was the hydrochlorothiazide plus 20 mmol of potassium regimen. A significant increase in magnesium levels was observed only in the group treated with the hydrochlorothiazide/triamterene combination. Each regimen provided continued control of mild to moderate hypertension.(Arch Intern Med. 1989;149:2677-2681)
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1989.00390120043009
UR  - http://dx.doi.org/10.1001/archinte.1989.00390120043009
ER  -