TY  - JOUR
T1  - ASsociation between active wegener's granulomatosis and anticytoplasmic antibodies
AU  - Tervaert J, van der Woude FJ, Fauci AS, et al
Y1  - 1989/11/01
N1  - 10.1001/archinte.1989.00390110055012
JO  - Archives of Internal Medicine
SP  - 2461
EP  - 2465
VL  - 149
IS  - 11
N2  - • Autoantibodies reacting with the cytoplasm of granulocytes and monocytes (anticytoplasmic antibodies [ACPAs]) were found in 42 of 45 patients with active Wegener's granulomatosis (WG) (sensitivity, 93%). Specificity was tested in selected groups of patients with closely related diseases. Of 58 patients without a diagnosis of WG, 2 had ACPAs (specificity, 97%). The significance of ACPA titration for assessing or predicting disease activity was evaluated in a 16-month prospective study of 35 patients with WG. Seventeen relapses were observed and all were preceded by a significant rise of the ACPA titer. Anticytoplasmic antibodies are a specific and sensitive marker for active WG; a rising titer is a sensitive marker for the development of a relapse.(Arch Intern Med. 1989;149:2461-2465)
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1989.00390110055012
UR  - http://dx.doi.org/10.1001/archinte.1989.00390110055012
ER  -