TY  - JOUR
T1  - LIver disease associated with exposure to 1,1,1 -trichloroethane
AU  - Hodgson MJ, Heyl AE, Van Thiel DH
Y1  - 1989/08/01
N1  - 10.1001/archinte.1989.00390080065015
JO  - Archives of Internal Medicine
SP  - 1793
EP  - 1798
VL  - 149
IS  - 8
N2  - • 1,1,1-Trichloroethane is a halogenated hydrocarbon solvent commonly used in industry because of its supposed lack of hepatotoxicity. Nonetheless, animal studies performed by several independent groups have shown the solvent to induce fat deposition, vacuolar degeneration, and centrilobular necrosis, changes similar to those seen after exposure to carbon tetrachloride, albeit of a much reduced magnitude, in animals exposed to the agent. Four patients with fatty liver disease whose work entailed substantial exposure to this agent were seen at the University of Pittsburgh (Pa). Based on this clinical experience, we believe that 1,1,1-trichloroethane should be reconsidered as an agent with potential hepatotoxicity in man.(Arch Intern Med. 1989;149:1793-1798)
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1989.00390080065015
UR  - http://dx.doi.org/10.1001/archinte.1989.00390080065015
ER  -