TY - JOUR T1 - MEthotrexate-associated, early-onset pancytopenia in rheumatoid arthritis AU - Doolittle GC, Simpson KM, Lindsley HB Y1 - 1989/06/01 N1 - 10.1001/archinte.1989.00390060140032 JO - Archives of Internal Medicine SP - 1430 EP - 1431 VL - 149 IS - 6 N2 - • A patient with rheumatoid arthritis presented with pancytopenia 3 weeks after initiation of low-dose methotrexate administered orally. She had minimal renal insufficiency and hypoalbuminemia prior to initiation of methotrexate therapy, and had received a nonsteroidal anti-inflammatory drug concurrently. Bone marrow recovery occurred within 3 weeks. Patients receiving low-dose methotrexate therapy for rheumatoid arthritis require early monitoring for bone marrow injury, especially those who have risk factors for possible methotrexate toxicity.(Arch Intern Med. 1989;149:1430-1431) SN - 0003-9926 M3 - doi: 10.1001/archinte.1989.00390060140032 UR - http://dx.doi.org/10.1001/archinte.1989.00390060140032 ER -