TY  - JOUR
T1  - VAncomycin allergy presenting as fever of unknown origin
AU  - Clayman MD, Capaldo RA
Y1  - 1989/06/01
N1  - 10.1001/archinte.1989.00390060137031
JO  - Archives of Internal Medicine
SP  - 1425
EP  - 1426
VL  - 149
IS  - 6
N2  - • A 37-year-old woman receiving long-term hemodialysis was admitted to the hospital with a fever of unknown origin (6 weeks of unexplained, persistent, low-grade fever). Although she had received vancomycin hydrochloride 5 days before the onset of fever, the drug was not suspected as the cause because of the duration of fever, the administration of vancomycin on prior occasions without incident, and the lack of allergic stigmata. After hospitalization, vancomycin and gentamicin sulfate were administered empirically. Immediately thereafter, her temperature rose to 40°C, and over the ensuing 24 hours, eosinophilia and a maculopapular rash developed that resolved entirely when antibiotic therapy was stopped and low-dose steroid therapy was instituted. The prolonged hypersensitivity reaction after a single dose of vancomycin is consistent with the greatly extended half-life of this drug in the population with end-stage renal disease and should alert physicians to the possibility of such persistent idiosyncratic reactions in this group.(Arch Intern Med. 1989;149:1425-1426)
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1989.00390060137031
UR  - http://dx.doi.org/10.1001/archinte.1989.00390060137031
ER  -