TY - JOUR T1 - PHenytoin hepatotoxicity masked by corticosteroids AU - Lisker-Melman M, Hoofnagle JH Y1 - 1989/05/01 N1 - 10.1001/archinte.1989.00390050148032 JO - Archives of Internal Medicine SP - 1196 EP - 1197 VL - 149 IS - 5 N2 - • The association of phenytoin and liver toxicity is well documented. This article describes a patient who underwent a trans sphenoidal resection of a pituitary tumor who developed phenytoin-induced hepatotoxicity that was masked by the simultaneous administration of corticosteroids for treatment of cerebral edema. In a patient receiving both medications, the systemic manifestations of the hypersensitivity to phenytoin may go unrecognized, leading to delayed identification of a potentially lethal complication of this commonly prescribed anticonvulsant.(Arch Intern Med. 1989;149:1196-1197) SN - 0003-9926 M3 - doi: 10.1001/archinte.1989.00390050148032 UR - http://dx.doi.org/10.1001/archinte.1989.00390050148032 ER -