TY  - JOUR
T1  - COntrol of hypertension and reversal of renal failure in undifferentiated connective tissue disease by enalapril
AU  - Strongwater SL, Galvanek EG, Stoff JS
Y1  - 1989/03/01
N1  - 10.1001/archinte.1989.00390030070013
JO  - Archives of Internal Medicine
SP  - 582
EP  - 585
VL  - 149
IS  - 3
N2  - • Activation of the renin angiotensin system is important in the development of accelerated hypertension and progression to acute renal failure in scleroderma and undifferentiated connective tissue disease. Inhibition of angiotensin-converting enzyme activity may effectively control blood pressure and ameliorate renal insufficiency. To our knowledge, we describe the first reversal of dialysis-dependent renal insufficiency by enalapril maleate and recovery and maintenance of near-normal renal function in a patient suffering from undifferentiated connective tissue disease with sclerodermatous features. The pathophysiologic mechanisms and long-term treatment implications with angiotensin-converting enzyme inhibitors in this setting are discussed.(Arch Intern Med 1989;149:582-585)
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1989.00390030070013
UR  - http://dx.doi.org/10.1001/archinte.1989.00390030070013
ER  -