TY  - JOUR
T1  - PRazosin-induced bradycardia in acute treatment of hypertension
AU  - Kobrin I, Stessman J, Yagil Y, Ben-Ishay D
Y1  - 1983/10/01
N1  - 10.1001/archinte.1983.00350100203049
JO  - Archives of Internal Medicine
SP  - 2019
EP  - 2023
VL  - 143
IS  - 10
N2  - To the Editor. 
    —Prazosin hydrochloride is a quinazolone derivative that has been shown to lower the BP by exerting a vasodilator effect on the resistance and capacitance vessels, resuiting from selective neuromuscular postsynaptic α-blockade.1 A notable peculiarity of therapy with this drug is the absence of reflex tachycardia, which is commonly encountered with the use of other peripheral vasodilators.1 A direct negative chronotropic effect of prazosin has been previously reported in experimental animals2,3 and in one clinical study of patients with severe heart failure.4The occurrence of a negative chronotropic effect of prazosin during the short-term treatment of hypertension has been overlooked. We recently used 2 mg of oral prazosin hydrochloride to achieve a rapid BP reduction in a group of 17 consecutively seen patients who had been referred to the emergency room for severe hypertension. Within three hours, concomitant to the drop in BP, 13 patients
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1983.00350100203049
UR  - http://dx.doi.org/10.1001/archinte.1983.00350100203049
ER  -