TY  - JOUR
T1  - AGranulocytosis associated with aprindine therapy
AU  - Bodenheimer HC, Jr, Samarel AM
Y1  - 1979/10/01
N1  - 10.1001/archinte.1979.03630470089027
JO  - Archives of Internal Medicine
SP  - 1181
EP  - 1182
VL  - 139
IS  - 10
N2  - Aprindine hydrochloride is an antiarrhythmic drug now under investigation. The drug is most effective in prophylaxis of ventricular dysrhythmias. Previously recognized toxic effects include neurological side effects, nausea, vomiting, as well as a reported association with agranulocytosis. To our knowledge, this is the first report of agranulocytosis associated with documented elevated serum concentrations of aprindine. Further correlation of drug levels with toxic reactions may help in establishing the mechanism of bone marrow suppression.(Arch Intern Med 139:1181-1182, 1979)
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1979.03630470089027
UR  - http://dx.doi.org/10.1001/archinte.1979.03630470089027
ER  -