TY  - JOUR
T1  - REnal changes in systemic lupus erythematosus
AU  - Kimberly RP
Y1  - 1979/09/01
N1  - 10.1001/archinte.1979.03630460092031
JO  - Archives of Internal Medicine
SP  - 1062
EP  - 1062
VL  - 139
IS  - 9
N2  - To the Editor.— 
    Dr Cunningham and associates, in the Archives (138:1560-1561, 1978), reported an interesting case of systemic lupus erythematosus (SLE) and transient changes in renal function, which they attribute to lupus interstitial nephritis. While this interpretation is intriguing in view of the emerging recognition of lupus interstitial renal disease,1 an alternative explanation of the patient's deteriorating condition and response to "therapy" is possible.Aspirin and other nonsteroidal antiinflammatory drugs (NSAID) may cause acute elevations of serum creatinine value and BUN level with decreased glomerular filtration rate,2.3 which may occasionally mimic incipient acute renal failure.4 These changes are rapidly reversible when the drug therapy is discontinued, but the recovery of renal function may be confused with a "therapeutic" effect of corticosteroids initiated at the time of NSAID withdrawal.2 Patients with SLE appear to be more susceptible to this effect than normal subjects, especially if there is
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1979.03630460092031
UR  - http://dx.doi.org/10.1001/archinte.1979.03630460092031
ER  -