TY  - JOUR
T1  - PEripheral ß-receptor responsiveness in patients with essential hypertension
AU  - McAllister RG, Jr, Love DW, Guthrie GP, Jr, Dominic J, Kotchen TA
Y1  - 1979/08/01
N1  - 10.1001/archinte.1979.03630450031011
JO  - Archives of Internal Medicine
SP  - 879
EP  - 881
VL  - 139
IS  - 8
N2  - Peripheral β-adrenergic receptor sensitivity was characterized in 24 patients with essential hypertension and in 13 agematched normotensive subjects using an isoproterenol hydrochloride bolus dose-response technique. Decreased β-receptor responsiveness to this exogenously administered β-agonist was observed in hypertensive patients; for an equivalent chronotropic effect, higher doses of isoproterenol were required in hypertensive subjects than in normal subjects. Among "normal-renin" hypertensive patients, β-receptor responsiveness was directly related to furosemide-stimulated plasma renin activity (PRA), suggesting that independently stimulated PRA may provide an indirect estimate of endogenous β-receptor sensitivity. Hypertensive patients whose mean arterial pressure fell at least 10 mm Hg after four weeks of treatment with hydrochlorothiazide had even further depression in β-receptor responsiveness, whereas receptor sensitivity was unchanged in patients whose blood pressure was unaffected. Thus, it is unlikely that this decreased receptor responsiveness in patients with untreated essential hypertension is a direct consequence of elevated arterial pressure.(Arch Intern Med 139:879-881, 1979)
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1979.03630450031011
UR  - http://dx.doi.org/10.1001/archinte.1979.03630450031011
ER  -