TY  - JOUR
T1  - EXacerbation of renal failure with doxycycline use
AU  - Whelton A
Y1  - 1979/05/01
N1  - 10.1001/archinte.1979.03630420089033
JO  - Archives of Internal Medicine
SP  - 603
EP  - 604
VL  - 139
IS  - 5
N2  - To the Editor.— 
    The temporally related exacerbation of renal failure associated with doxycycline use, as reported by Dr Orr and colleagues in the Archives (138:793-794, 1978), is certainly of interest and importance. However, the report serves to emphasize the caution with which one should interpret such clinical findings in the absence of pertinent serum drug concentration data and the intercurrent use of other potent compounds that influence renal function.The case report indicates that, after doxycycline therapy, the patient in question received a potent diuretic twice daily at a time when she exhibited peripheral edema. She subsequently manifested evidence of fluid depletion and mild postural hypotension. The contribution of doxycycline to the pathogenesis of the patient's fluid depletion must remain speculative at best. It is perhaps worth noting that it is almost invariably the demethylchlortetracycline form of tetracycline that produces direct renal tubular concentration effects.1-3 The role of the
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1979.03630420089033
UR  - http://dx.doi.org/10.1001/archinte.1979.03630420089033
ER  -