TY  - JOUR
T1  - ARrhythmogenic effects of orally administered bronchodilators
AU  - Banner AS, Sunderrajan EV, Agarwal MK, Addington WW
Y1  - 1979/04/01
N1  - 10.1001/archinte.1979.03630410042015
JO  - Archives of Internal Medicine
SP  - 434
EP  - 437
VL  - 139
IS  - 4
N2  - The respiratory and circulatory effects of orally administered ephedrine sulfate, 25 mg, aminophylline, 400 mg, terbutaline sulfate, 5 mg, and placebo were evaluated in 20 patients with ventricular arrhythmia by a double-blind crossover method. The bronchodilator effect of terbutaline was similar to that of aminophylline over four hours but superior to ephedrine at the fourth hour. Both terbutaline and ephedrine exhibited chronotropic effects, with the effect of terbutaline greater than that of ephedrine at the fourth hour. The effect of aminophylline on heart rate did not differ from placebo. Only terbutaline was associated with an increase in ventricular ectopic beats. Ventricular tachycardia occurred in three patients treated with terbutaline and in one patient with ephedrine. There were no significant changes in blood pressure. Orally administered terbutaline should not be regarded as safer than orally administered ephedrine or aminophylline in patients with arrhythmias.(Arch Intern Med 139:434-437, 1979)
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1979.03630410042015
UR  - http://dx.doi.org/10.1001/archinte.1979.03630410042015
ER  -