TY  - JOUR
T1  - FAtal benign phenytoin lymphadenopathy
AU  - McCarthy LJ, Aguilar JC, Ransburg R
Y1  - 1979/03/01
N1  - 10.1001/archinte.1979.03630400081029
JO  - Archives of Internal Medicine
SP  - 367
EP  - 368
VL  - 139
IS  - 3
N2  - A 71-year-old man had status epilepticus and was treated with phenytoin (Dilantin) sodium. Subsequently, an absolute eosinophilia developed, which increased and reached its zenith immediately before the patient died. At autopsy, anasarca and an interstitial nephritis characterized predominantly by eosinophils and occasional focal necrotizing arteriolar glomerular lesions were found. Portal areas also contained an eosinophilic infiltrate. It has been previously stressed that exfoliative dermititis is often the initiating sign of an allergic hypersensitivity reaction with phenytoin therapy. In view of this, we would suggest that a potential first sign of such an underlying reaction may be the development of an otherwise unexplained absolute eosinophilia.(Arch Intern Med 139:367-368, 1979)
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1979.03630400081029
UR  - http://dx.doi.org/10.1001/archinte.1979.03630400081029
ER  -