TY - JOUR T1 - FAilure of trimethoprim/ sulfamethoxazole in invasive nocardia asteroides infection AU - Geiseler P, Check F, Lamothe F, Andersen BR Y1 - 1979/03/01 N1 - 10.1001/archinte.1979.03630400071025 JO - Archives of Internal Medicine SP - 355 EP - 356 VL - 139 IS - 3 N2 - A case of pulmonary nocardiosis occurred with progressive involvement of the pleura, pericardium, mediastinum, and sternum. Surgical resection and drainage procedures followed by administration of the drug combination, trimethoprim/sulfamethoxazole, over a six-month period led to clinical recovery. Discontinuation of drug therapy, however, was followed by relapse and further invasion by the same organism. A literature survey of Nocardia asteroides infections treated with trimethoprim/sulfamethoxazole disclosed that posttreatment follow-up is often too brief or unknown, making the ultimate success of therapy uncertain.(Arch Intern Med 139:355-356, 1979) SN - 0003-9926 M3 - doi: 10.1001/archinte.1979.03630400071025 UR - http://dx.doi.org/10.1001/archinte.1979.03630400071025 ER -