TY  - JOUR
T1  - PRetherapeutic morbidity in the prognostic staging of acute leukemia
AU  - Boyd NF, Clemens JD, Feinstein AR
Y1  - 1979/03/01
N1  - 10.1001/archinte.1979.03630400044018
JO  - Archives of Internal Medicine
SP  - 324
EP  - 328
VL  - 139
IS  - 3
N2  - To classify the clinical severity of acute leukemia, we have used the degrees of pretherapeutic infection and hemorrhage to construct a taxonomy containing three "stages." The stages are associated with survival gradients that are clinically and statistically distinctive in both acute lymphoblastic leukemia and acute nonlymphoblastic leukemia. Median survival ranged from 64.0 months for stage 1 to 10.5 months for stage 3 in acute lymphoblastic leukemia, and from 7.1 months for stage 1 to 1.2 months for stage 3 in acute nonlymphoblastic leukemia. The gradients, which persist when other prognostic factors and secular therapeutic changes are taken into account, are more distinctive than those found with other forms of stratification.(Arch Intern Med 139:324-328, 1979)
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1979.03630400044018
UR  - http://dx.doi.org/10.1001/archinte.1979.03630400044018
ER  -