TY  - JOUR
T1  - APparent cure of intracranial nocardia asteroides infection by minocycline
AU  - Wren MV, Savage AM, Alford RH
Y1  - 1979/02/01
N1  - 10.1001/archinte.1979.03630390099037
JO  - Archives of Internal Medicine
SP  - 249
EP  - 250
VL  - 139
IS  - 2
N2  - Currently preferred therapy for CNS Nocardia infection is high-dose sulfonamide coupled with surgical drainage. Neither of these could be used in our patient; this led to therapy with minocycline alone. Several months after completion of minocycline therapy, the patient apparently is cured. His favorable outcome probably resulted from a combination of susceptibility of the organism to minocycline coupled with good CNS penetration of the agent resulting in CNS levels of drug 16 to 22 times higher than the Nocardia inhibitory concentration.(Arch Intern Med 139:249-250, 1979)
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1979.03630390099037
UR  - http://dx.doi.org/10.1001/archinte.1979.03630390099037
ER  -