TY  - JOUR
T1  - NEphrotic syndrome associated with methimazole therapy
AU  - Reynolds L, Bhathena D
Y1  - 1979/02/01
N1  - 10.1001/archinte.1979.03630390088030
JO  - Archives of Internal Medicine
SP  - 236
EP  - 237
VL  - 139
IS  - 2
N2  - Thionamide drugs are widely used in the management of hyperthyroidism and are infrequently associated with adverse reactions. We report the development of the nephrotic syndrome during methimazole (Tapazole) therapy in a young man with Graves' disease. His proteinuria remitted promptly with discontinuance of the drug, and renal histologic features bore a striking resemblance to the toxic nephrosis induced in animals by the aminonucleoside of puromycin. In view of the histologic similarities, we propose that methimazole acted as a direct glomerular toxin, inducing the nephrotic syndrome in this patient.(Arch Intern Med 139:236-237, 1979)
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1979.03630390088030
UR  - http://dx.doi.org/10.1001/archinte.1979.03630390088030
ER  -