TY  - JOUR
T1  - DEfective platelets in essential thrombocythemia
AU  - Spaet TH, Lejnieks I, Gaynor E, Goldstein ML
Y1  - 1969/08/01
N1  - 10.1001/archinte.1969.00300180007002
JO  - Archives of Internal Medicine
SP  - 135
EP  - 141
VL  - 124
IS  - 2
N2  - Platelets from three consecutive patients with essential thrombocythemia were studied. In each case there were characteristic abnormalities. These included absent aggregation in response to epinephrine and reduced aggregation by adenosine diphosphate. The platelets were aggregated normally by collagen. Uptake by platelets of serotonin labeled with radioactive carbon 14C was reduced, and there was possibly reduced platelet adenosine diphosphatase activity. The platelets supported normal clot retraction, and gave normal platelet factor 3 availability. The abnormality appears to be specific for the disease rather than a nonspecific reflection of thrombocythemia.
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1969.00300180007002
UR  - http://dx.doi.org/10.1001/archinte.1969.00300180007002
ER  -