TY  - JOUR
T1  - MOdification of renal allograft rejection in man
AU  - Carpenter CB, Merrill JP
Y1  - 1969/05/01
N1  - 10.1001/archinte.1969.00300150019004
JO  - Archives of Internal Medicine
SP  - 501
EP  - 513
VL  - 123
IS  - 5
N2  - Improved success in clinical renal transplantation is dependent upon optimal matching of donor and recipient tissue antigens, and upon more effective and less toxic means of immunosuppression. Variations in the clinical and pathological manifestations of rejection are a result of the individual's response to foreigntissue antigens which are as yet incompletely defined, and perhaps also to individual differences with regard to the effects of immunosuppressive therapy. In addition to leukocyte typing for HL-A antigens, avoidance of presensitization is a crucial problem for a transplant program. Currently employed therapy, including cytotoxic agents and antilymphocyte globulin (ALG), is not always effective and frequently produces serious infectious complications. Improved methods for production and testing of ALG are needed, as well as investigation of other means of tolerance induction.
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1969.00300150019004
UR  - http://dx.doi.org/10.1001/archinte.1969.00300150019004
ER  -