TY  - JOUR
T1  - ROle of insulin in the hepatic handling of glucose
AU  - Madison LL
Y1  - 1969/03/01
N1  - 10.1001/archinte.1969.00300130066010
JO  - Archives of Internal Medicine
SP  - 284
EP  - 292
VL  - 123
IS  - 3
N2  - The effects of insulin on hepatic glucose balance, including data on hepatic glucose output, production (glycogenolysis and gluconeogenesis), and uptake in normal and diabetic animals are reviewed. Data from in vivo studies are presented which indicate that these changes in the hepatic handling of glucose following insulin administration are direct effects of insulin on the liver rather than effects secondary to insulin's action on muscle and adipose tissue. These studies indicate that these hepatic actions of insulin are vital to the organism both during feasting and prolonged fasting.
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1969.00300130066010
UR  - http://dx.doi.org/10.1001/archinte.1969.00300130066010
ER  -