TY  - JOUR
T1  - PRimary aldosteronism
AU  - M.D.B.
Y1  - 1969/02/01
N1  - 10.1001/archinte.1969.00300120089015
JO  - Archives of Internal Medicine
SP  - 201
EP  - 202
VL  - 123
IS  - 2
N2  - It is now almost 15 years since Dr. Jerome Conn focused so sharply and accurately upon the occurrence of a hypertensive syndrome caused by a tumor of the adrenal cortex. The adenoma was considered to be producing in excess the normally secreted salt-retaining steroid of the adrenal gland, aldosterone, and, thus, the term primary aldosteronism was used. Furthermore, surgical removal of the tumor led to a reduction in the level of the elevated blood pressure. Clinicians everywhere quickly began the search for other patients with this disorder. Conn had established some very clear-cut criteria by which to judge preoperatively the existence of the tumor: a low serum potassium level, a low sodium to potassium concentration ratio in the saliva, a low serum chloride level, an elevated serum bicarbonate level, an elevated plasma pH, an increased excretion of aldosterone, and the excretion of normal amounts of other adrenal steroids. In subsequent
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1969.00300120089015
UR  - http://dx.doi.org/10.1001/archinte.1969.00300120089015
ER  -