TY  - JOUR
T1  - MAnipulation by corticotropin and cortisol of aldosterone secretion in primary aldosteronism
AU  - Newton MA, Laragh JH
Y1  - 1969/02/01
N1  - 10.1001/archinte.1969.00300120035005
JO  - Archives of Internal Medicine
SP  - 147
EP  - 151
VL  - 123
IS  - 2
N2  - Administration of hydrocortisone to three patients with primary aldosteronism reduced aldosterone excretion to normal. Dexamethasone failed to suppress aldosterone in two others. In four out of five patients given corticotropin, aldosterone suppression followed initial stimulation. The suppression did not appear to involve any known regulatory influences, since no associated changes in plasma renin or sodium and potassium balance were observed. Possibly, increased circulating cortisol levels exerted a direct influence on the adrenal cortex. Since at least four of these patients had a typical aldosterone-secreting adenoma, it would appear that aldosterone suppression by either corticotropin or cortisol is not a characteristic feature of hyperaldosteronism due to bilateral adrenal hyperfunction. Manipulation of tumor function by these hormones suggests that at least some aldosterone-secreting tumors are not completely autonomous.
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1969.00300120035005
UR  - http://dx.doi.org/10.1001/archinte.1969.00300120035005
ER  -