TY  - JOUR
T1  - DIabetes mellitus and cirrhosis of the liver
AU  - BLOODWORTH JB, JR.
Y1  - 1961/11/01
N1  - 10.1001/archinte.1961.03620110035006
JO  - Archives of Internal Medicine
SP  - 695
EP  - 701
VL  - 108
IS  - 5
N2  - One of the first pathologic changes described in the diabetic patient was an enlarged, fatty liver.1 Since that time, numerous studies have indicated that a fatty liver is present in from 15% to 50% of diabetic patients.2,3 Laboratory evidence of liver dysfunction is present in a significant percentage of diabetic patients.3-5Fatty metamorphosis of the liver is an integral part of the pathologic picture in the majority of cases of cirrhosis of the liver.6 Many investigators have stated that if a fatty liver from any cause persists, cirrhosis will develop.7 Chaikoff and Connor reported that the production of a fatty liver in the dog by a high-fat diet will ultimately lead to cirrhosis of the liver.8 Pancreatectomized dogs maintained on insulin develop a fatty liver and ultimately show cirrhosis of the liver.9Despite these facts, a direct relationship between diabetes mellitus and cirrhosis
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1961.03620110035006
UR  - http://dx.doi.org/10.1001/archinte.1961.03620110035006
ER  -