TY  - JOUR
T1  - PRimary hyperparathyroidism with depression
AU  - REINFRANK RF
Y1  - 1961/10/01
N1  - 10.1001/archinte.1961.03620100098014
JO  - Archives of Internal Medicine
SP  - 606
EP  - 610
VL  - 108
IS  - 4
N2  - Prior to 1925, the occasional autopsy findings of enlargement of the parathyroid glands in patients with generalized bone disease were thought to be the result of a compensatory hypertrophy of the glands. In 1925 Felix Mandl treated a patient with generalized osteitis fibrosa with injections of parathyroid extract and attempts at parathyroid transplants. Since the patient did not improve, a neck exploration was done, and an adenomatous enlargement of one of the parathyroids was found and removed. The patient steadily improved.1The demonstration that a serious metabolic disorder of bone could be surgically corrected stimulated a widespread interest in the early diagnosis of primary hyperparathyroidism which has continued to the present. Metabolic bone disease of the osteitis fibrosa variety, nephrolithiasis or nephrocalcinosis, or a combination of these manifestations, have been the clinical hallmarks of primary hyperparathyroidism.In 1957 St. Goar called attention to the frequency with which gastrointestinal symptoms
SN  - 0003-9926
M3  - doi: 10.1001/archinte.1961.03620100098014
UR  - http://dx.doi.org/10.1001/archinte.1961.03620100098014
ER  -